{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:36:41Z","timestamp":1791326201099,"version":"4.3.1"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"28","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Intracerebral hemorrhage (ICH) is correlated with high rate of death and poor outcome. Leukocytes participate in secondary brain injury in ICH. It is still not clear that whether leukocytosis can predict outcome in ICH. This study was performed to summarize that current evidences about the association between baseline leukocytosis and outcome in ICH patients in a systematic review and meta-analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Published studies were searched in 5 databases. Original studies about association between baseline leukocytosis and outcome in ICH were included. Pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were achieved to evaluate the association between leukocytosis and prognosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A total of 19 eligible studies with 6417 patients were analyzed in this study. Meta-analysis showed baseline leukocyte count increase was significantly associated with worse overall (OR\u200a=\u200a1.13, 95% CI 1.05\u20131.21, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.001), short-term (OR\u200a=\u200a1.20, 95% CI 1.05\u20131.38, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.009), and long-term functional outcome (OR\u200a=\u200a1.12, 95% CI 1.04\u20131.20, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.004). Baseline leukocytosis defined by cut-off values had significant association with worse overall functional outcome (OR\u200a=\u200a1.95, 95% CI 1.01\u20133.76, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.046). Baseline leukocyte count increase was significantly associated with higher overall (OR\u200a=\u200a1.10, 95% CI 1.02\u20131.18, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.011) and long-term mortality (OR\u200a=\u200a1.12, 95% CI 1.03\u20131.22, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.007). Baseline leukocytosis defined by cut-off values was significantly associated with higher overall (OR\u200a=\u200a1.67, 95% CI 1.23\u20132.27, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.001) and short-term mortality (OR\u200a=\u200a1.74, 95% CI 1.12\u20132.70, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.014).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Baseline leukocytosis could be helpful in predicting prognosis in ICH patients. However, its prognostic value should be verified by further studies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000016281","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T20:42:01Z","timestamp":1562964121000},"page":"e16281","source":"Crossref","is-referenced-by-count":17,"title":["Prognostic impact of leukocytosis in intracerebral 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