{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T19:33:04Z","timestamp":1711049584669},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>X-ray repair cross-complementing group 1 (XRCC1) single nucleotide polymorphisms (SNPs) might correlate with male infertility susceptibility. This association has been described; however, the findings remain inconsistent. Consequently, this meta-analysis was conducted to characterize the relationship between XRCC1 SNPs and male infertility susceptibility.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\/main results:<\/jats:title>\n            <jats:p>Studies were systematically searched in databases to evaluate the association between SNPs of XRCC1 and infertility in males. The effect measures chosen were the 95% confidence intervals (95% CIs) and odds ratios (ORs). A total of 7 studies, including 6 case-controlled studies on XRCC1 Arg399Gln and 3 case-controlled studies on XRCC1 Arg194Trp, were included. Ultimately, the results of this analysis revealed that XRCC1 Arg399Gln SNPs were significantly associated with infertility in males in homozygote comparisons (GG vs GA+AA: OR\u200a=\u200a0.614, 95% CI: 0.40\u20130.937, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.024). This meta-analysis did not demonstrate a relationship between XRCC1 Arg194Trp and male infertility risk.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Our study indicated that XRCC1 Arg399Gln polymorphism was associated with a significantly decreased male infertility risk, but not XRCC1 Arg194Trp.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000020008","type":"journal-article","created":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T03:35:02Z","timestamp":1588390502000},"page":"e20008","source":"Crossref","is-referenced-by-count":1,"title":["Association between polymorphisms in the XRCC1 gene and male infertility risk"],"prefix":"10.1097","volume":"99","author":[{"given":"Zhengsheng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology Surgery"},{"name":"Center of Diagnosis and Treatment of Urinary System Diseases"},{"name":"Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luqi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Xiamen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiongbo","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Fujian Medical University, Xiamen, Fujian, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinchun","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery"},{"name":"Center of Diagnosis and Treatment of Urinary System Diseases"},{"name":"Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2020,5]]},"reference":[{"key":"R1-20230915","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1093\/humrep\/16.8.1768","article-title":"Contribution of environmental factors to the risk of male infertility","volume":"16","author":"Oliva","year":"2001","journal-title":"Hum Reprod"},{"key":"R2-20230915","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/S0022-5347(05)65109-9","article-title":"Best practice policies for male infertility","volume":"167","author":"Jarow","year":"2002","journal-title":"J 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