{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T21:36:06Z","timestamp":1726436166226},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>To study the changes of pancreas, thyroid, adrenal, parathyroid and gonadal organ-specific antibodies in patients with type 1 diabetic patients and to explore the risk of development to other endocrine gland autoimmune diseases.<\/jats:p>\n            <jats:p>Fifty one patients with type 1 diabetes mellitus were selected. ELISA was used to detect islet, adrenal gland, Parathyroid, gonadal organ-specific antibody levels, the level of thyroid-related antibodies by lectrochemiluminescence.<\/jats:p>\n            <jats:p>Compared with the healthy control group, the levels of the 17-\u03b1-OHAb, 21-OHAb, NALP5Ab, P450sccAb, and CaSRAb in the T1DM group were significantly higher. GADAb-positive patients were more likely to have TPOAb-positive patients than GADAb-negative patients, and the positive rate of 2 thyroid antibodies in GADAb-positive patients was significantly higher than that in GADAb-negative patients. The presence of these antibodies is related to the age of onset of type 1 diabetes or Patient age. In combination with 1 or 2 islet antibody-positive patients, the combined non-islet antibody positive rate was higher than that of islet antibody-negative patients.<\/jats:p>\n            <jats:p>Patients with type 1 diabetes with other autoimmune diseases at risk significantly increased compared with normal, of which the most common thyroid autoimmune disease, thyroid antibodies and hormone levels should be routinely detected at the first visit and long-term follow-up.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000020437","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T19:25:31Z","timestamp":1590693931000},"page":"e20437","source":"Crossref","is-referenced-by-count":1,"title":["The study on the risk of other endocrine glands autoimmune diseases in patients with type 1 diabetes mellitus"],"prefix":"10.1097","volume":"99","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Hebei General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuchun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hebei General Hospital"},{"name":"Department of Endocrinology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hebei General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zelin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hebei General Hospital"},{"name":"Department of Endocrinology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hebei General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hebei General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijiao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hebei General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luping","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hebei General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environment and Population Health of Hebei Province, Department of Epidemiology and Statistics, Hebei Medical University, Shijiazhuang, Hebei, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"issue":"(Suppl 6)","key":"R1-20240308","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1399-5448.2007.00280.x","article-title":"Worldwide childhood type 1 diabetes incidence--what can we learn from epidemiology?","volume":"8","author":"Soltesz","year":"2007","journal-title":"Pediatric Diabetes"},{"key":"R2-20240308","doi-asserted-by":"crossref","first-page":"6219730","DOI":"10.1155\/2016\/6219730","article-title":"Effect of associated Autoimmune diseases on type 1 diabetes mellitus incidence and metabolic control in children and adolescents","volume":"2016","author":"Krzewska","year":"2016","journal-title":"Biomed Res Int"},{"key":"R3-20240308","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1210\/jcem.83.4.4682","article-title":"Clinical review 93: Autoimmune polyglandular syndrome type 1","volume":"83","author":"Betterle","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"R4-20240308","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0167-5699(96)10008-6","article-title":"The nature of autoantigens targeted in autoimmune endocrine diseases","volume":"17","author":"Song","year":"1996","journal-title":"Immunol Today"},{"key":"R5-20240308","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/cen.13482","article-title":"Autoantibodies against the calcium-sensing receptor and cytokines in autoimmune polyglandular syndromes types 2, 3 and 4","volume":"88","author":"Kemp","year":"2018","journal-title":"Clin Endocrinol"},{"key":"R6-20240308","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/dme.12677","article-title":"Autoantibody-defined risk for Type 1 diabetes mellitus in a general population of schoolchildren: results of the Karlsburg type 1 diabetes risk study after 18 years","volume":"32","author":"Till","year":"2015","journal-title":"Dia Med"},{"key":"R7-20240308","first-page":"2455","article-title":"Glutamic acid decarboxylase antibodies in relation to other autoantibodies and genetic risk markers in children with newly diagnosed insulin-dependent diabetes. 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