{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:35:11Z","timestamp":1767706511614},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"the Guangdong Science and Technology Basic Conditions Support Project","award":["No. 2018A030321015"],"award-info":[{"award-number":["No. 2018A030321015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Backgrounds:<\/jats:title>\n            <jats:p>Previous studies indicated inconsistent results for the treatment effect of repetitive transcranial magnetic stimulation (rTMS) on post-stroke aphasics. The study conducted a meta-analysis to evaluate whether the rTMS with different frequencies demonstrated any effect in patients with post-stroke aphasia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Electronic databases (PubMed, Web of Science, Medline, EMBASE, and Google Scholar) were searched for articles published before July 2019. Statistical analyses were made using STATA 12.0 software. Standard mean difference (SMD) with 95% confidence intervals (CI) were calculated for the treatment effect of rTMS on post-stroke aphasia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Meta-analysis indicated significant treatment effects on naming of rTMS in post-stroke aphasics (SMD 0.76, 95%CI 0.16 to 1.36, I<jats:sup>2<\/jats:sup>\u200a=\u200a76.9%, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a.001). Subgroup analyses showed significant treatment effects on naming of low frequency (LF)-rTMS (SMD 0.40, 95%CI 0.10 to 0.69, I<jats:sup>2<\/jats:sup>\u200a=\u200a0.0%, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.671). However, the changes in repetition and comprehension following stimulation were not significant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In conclusion, we provide preliminary evidence that both LF-rTMS and high-frequency-rTMS might be relatively effective and safe treatment for post-stroke aphasics. However, LF-rTMS mainly plays a short-term role in subacute post-stroke aphasics. Longer-term and large-scale studies are essential to explore the effect of rTMS with different frequencies on post-stroke aphasia.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000020439","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T05:16:16Z","timestamp":1591852576000},"page":"e20439","source":"Crossref","is-referenced-by-count":21,"title":["Effects of repetitive transcranial magnetic stimulation with different frequencies on post-stroke aphasia"],"prefix":"10.1097","volume":"99","author":[{"given":"Tiao","family":"Li","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Jinan University, Guangzhou"},{"name":"Department of Rehabilitation Medicine, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"R1-20230915","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000118376","article-title":"Aphasia during the acute phase in ischemic stroke","volume":"25","author":"Inatomi","year":"2008","journal-title":"Cerebrovasc Dis"},{"key":"R2-20230915","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3109\/09638288.2010.488712","article-title":"Predicting outcome after stroke: the role of aphasia","volume":"33","author":"Gialanella","year":"2011","journal-title":"Disabil Rehabil"},{"key":"R3-20230915","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jfludis.2010.05.008","article-title":"Health-related quality of life in people with aphasia: implications for fluency disorders quality of life research","volume":"35","author":"Cruice","year":"2010","journal-title":"J Fluency Disord"},{"key":"R4-20230915","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0269215509346090","article-title":"Psychological distress after stroke and aphasia: the first six months","volume":"24","author":"Hilari","year":"2010","journal-title":"Clin Rehabil"},{"key":"R5-20230915","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S1474-4422(06)70525-7","article-title":"Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke?","volume":"5","author":"Hummel","year":"2006","journal-title":"Lancet Neurol"},{"key":"R6-20230915","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1176\/appi.ajp.159.7.1093","article-title":"Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders","volume":"159","author":"Hoffman","year":"2002","journal-title":"Am J Psychiatry"},{"key":"R7-20230915","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brs.2016.11.009","article-title":"Neurobiological after-effects of non-invasive brain stimulation","volume":"10","author":"Cirillo","year":"2017","journal-title":"Brain Stimul"},{"key":"R8-20230915","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1080\/02687038.2012.710316","article-title":"Finding the right words: transcranial magnetic stimulation improves discourse productivity in non-fluent aphasia after stroke","volume":"26","author":"Medina","year":"2012","journal-title":"Aphasiology"},{"key":"R9-20230915","first-page":"241","article-title":"Efficacy and safety of transcranial magnetic stimulation in patients with non-fluent aphasia, following an ischaemic stroke. 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