{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T16:30:32Z","timestamp":1770568232777,"version":"3.49.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"36","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Science & Technology Department of Sichuan Province","award":["No. 2018JY0446"],"award-info":[{"award-number":["No. 2018JY0446"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Rheumatoid arthritis has the characteristics of slow progression, long course, and repeated attacks. At present, western medicine commonly used in clinical practice not only reduces pain and improves symptoms, but also has more adverse reactions, affecting the health, and life of patients. In ancient China, Huangqi Guizhi Wuwu decoction was used by doctors to treat rheumatoid arthritis, with remarkable effect. In recent years, many clinical studies have also shown that Huangqi Guizhi Wuwu decoction has reliable effect in treating rheumatoid arthritis, but there is no evidence of evidence-based medicine. Therefore, this study aims to systematically evaluate the clinical efficacy and safety of Huangqi Guizhi Wuwu decoction in the treatment of rheumatoid arthritis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Using computer to retrieve PubMed, The Cochrance Library, Embase, Web of Science, CNKI, VIP and Wanfang database, in addition manually retrieve Google academic and Baidu academic to collect all randomized controlled trials for Huangqi Guizhi Wuwu decoction in the treatment of rheumatoid arthritis, including relevant academic journal and conference papers, dissertations, from the establishment of the database to July 2020. After 2 evaluators independently screened the literature, extracted the data, and evaluated the risk of bias included in the study, RevMan5.3 software was used to analyze the data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>This research evaluate the efficacy and safety of Huangqi Guizhi Wuwu decoction in treating Rheumatoid arthritis from the aspects of clinical efficacy rate, visual analog scale (VAS), swollen joint count (SJC), morning stiffness time, Rrythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), and adverse reaction incidence.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>This study will provide reliable evidence for the clinical application of Huangqi Guizhi Wuwu decoction in the treatment of rheumatoid arthritis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Ethics and dissemination:<\/jats:title>\n            <jats:p>The private information from individuals will not publish. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OSF Registration number:<\/jats:title>\n            <jats:p>DOI 10.17605\/OSF.IO\/RZY3V.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000022011","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T14:20:24Z","timestamp":1598970024000},"page":"e22011","source":"Crossref","is-referenced-by-count":8,"title":["The efficacy and safety of Huangqi Guizhi Wuwu decoction for rheumatoid arthritis"],"prefix":"10.1097","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2524-2562","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihua","family":"Fan","sequence":"additional","affiliation":[{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Xin","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuetong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaihan","family":"Deng","sequence":"additional","affiliation":[{"name":"Pengzhou Hospital of Traditional Chinese Medicine, Pengzhou, Sichuan Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Jia","sequence":"additional","affiliation":[{"name":"Chengdu University of 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