{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T18:30:51Z","timestamp":1782585051138,"version":"3.54.5"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"49","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Key Research and Development Project of Hainan Sichuan Province","award":["2018SZ0068"],"award-info":[{"award-number":["2018SZ0068"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction:<\/jats:title>\n            <jats:p>Known as an endocrine disorder, Polycystic ovary syndrome (PCOS) has posed an influence on 6% to 20% reproductive females worldwide. The commonly used pharmaceutical agents currently are Oral Contraceptives (OCs) and insulin-sensitizing agents. However, OCs is not appropriate for females pursuing pregnancy. Furthermore, some of insulin-sensitizing agents are found to be related to a high incidence of gastrointestinal adverse effects. In this regard, the effectiveness of Chinese herbal medicine in handling reproductive and metabolic defects simultaneously has been proved by extensive evidence. In this research, the effectiveness and safety of Chinese herbal medicine for obese females with PCOS were examined.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and analysis:<\/jats:title>\n            <jats:p>In the systematic review, we searched databases of AMED, Science Online, EMbase, WorldSciNet, the Cochrane Library, PubMed, Nature, MEDLINE, China National Knowledge Infrastructure, the Wanfang Databse and China Biology Medicine Disc and the Chongqing VIP Chinese Science and Technology Periodical Database, to find out the papers published in Chinese or English by September 25, 2020 in this field. In addition, potential reference lists, relevant conference proceedings, qualified studies, related system reviews and other resources were also considered. Two researchers were responsible for independently selecting the research papers, collecting data, and evaluating research quality. Moreover, the data were synthesized with the combination of a fixed-effects or random-effects model with the heterogeneity test. According to the objective and self-reported assessment, the primary outcomes will be Nausea and vomiting were primary outcomes. RevMan 5 software was used to analyze the collected data, the evidence level of which was evaluated by GRADE. The selection between the fixed-effects and random-effects models was determined by the heterogeneity level. In addition to the 95% Confidence Interval (CI), odds ratio (OR), or risk ratio (RR) was applied to the 2 categories. Moreover, 95% CI and standardized mean difference (SMD) or the weighted mean difference (WMD) were taken as the continuous variables. When existing meaningful heterogeneity could not be explained by any assessment such as subgroup analysis, we would not conduct a meta-analysis. During the subgroup analysis, each subgroup in specific cases should be comprehensively considered.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Ethics and dissemination:<\/jats:title>\n            <jats:p>The evaluation of rights or personal information of patients was not involved in the systematic review. Hence, we need not gain approval from ethical institutions. This paper will be present at related conferences for communication and published in journals.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>Open Science Framework (OSF) Preregistration: osf.io\/yp86h.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000022982","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T04:13:34Z","timestamp":1607055214000},"page":"e22982","source":"Crossref","is-referenced-by-count":9,"title":["Chinese herbal medicine on treating obese women with polycystic ovary syndrome"],"prefix":"10.1097","volume":"99","author":[{"given":"Ning","family":"Ding","sequence":"first","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine"},{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4417-3312","authenticated-orcid":false,"given":"Rensong","family":"Yue","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine"},{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjing","family":"Yang","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine"},{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"R1-20230916","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"R2-20230916","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2337\/dc18-1738","article-title":"The impact of obesity on the incidence of type 2 diabetes among women with polycystic ovary syndrome","volume":"42","author":"Kakoly","year":"2019","journal-title":"Diabetes Care"},{"key":"R3-20230916","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.molmed.2006.05.006","article-title":"Molecular mechanisms of insulin resistance in polycystic ovary syndrome","volume":"12","author":"Diamanti-Kandarakis","year":"2006","journal-title":"Trends Mol Med"},{"key":"R4-20230916","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/jc.2013-2350","article-title":"Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline","volume":"98","author":"Legro","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"R5-20230916","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1210\/jc.2018-00241","article-title":"Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline","volume":"103","author":"Martin","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"R6-20230916","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1210\/jc.2004-1376","article-title":"Effects of rosiglitazone in obese women with polycystic ovary syndrome and severe insulin resistance","volume":"90","author":"Sepilian","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R7-20230916","first-page":"CD003053","article-title":"Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility","volume":"11","author":"Morley","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"R8-20230916","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/1753-0407.12559","article-title":"Evaluation of the Chinese herbal medicine Jinlida in type 2 diabetes patients based on stratification: results of subgroup analysis from a 12-week trial","volume":"10","author":"Tian","year":"2018","journal-title":"J Diabetes"},{"key":"R9-20230916","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jpba.2015.12.020","article-title":"Serum metabolomics study of Traditional Chinese medicine formula intervention to polycystic ovary syndrome","volume":"120","author":"Lu","year":"2016","journal-title":"J Pharm Biomed Anal"},{"key":"R10-20230916","doi-asserted-by":"crossref","DOI":"10.3390\/jcm7070179","article-title":"Investigation on the use of traditional Chinese medicine for polycystic ovary syndrome in a nationwide prescription database in Taiwan","volume":"7","author":"Liao","year":"2018","journal-title":"J Clin Med"},{"key":"R11-20230916","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1093\/humrep\/del142","article-title":"Abnormal glucose tolerance in Chinese women with polycystic ovary syndrome","volume":"21","author":"Chen","year":"2006","journal-title":"Hum Reprod"},{"key":"R14-20230916","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"R15-20230916","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.fertnstert.2018.08.021","article-title":"Beyond fertility: polycystic ovary syndrome and long-term health","volume":"110","author":"Cooney","year":"2018","journal-title":"Fertil Steril"},{"key":"R16-20230916","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/humupd\/dmu012","article-title":"Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"20","author":"Barry","year":"2014","journal-title":"Hum Reprod Update"},{"key":"R17-20230916","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/cen.13477","article-title":"The risk of metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"88","author":"Behboudi-Gandevani","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R18-20230916","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/humupd\/dmy007","article-title":"Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression","volume":"24","author":"Kakoly","year":"2018","journal-title":"Hum Reprod Update"},{"key":"R19-20230916","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/humrep\/dex044","article-title":"High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"32","author":"Cooney","year":"2017","journal-title":"Hum Reprod"},{"key":"R20-20230916","doi-asserted-by":"crossref","DOI":"10.1016\/S0924-9338(12)75501-3","article-title":"Marital sexual satisfaction in women with polycystic ovary syndrome","volume":"27","author":"Aloulou","year":"2012","journal-title":"Euro Psychiatry"},{"key":"R21-20230916","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/humupd\/dms029","article-title":"Emotional distress is a common risk in women with polycystic ovary syndrome: a systematic review and meta-analysis of 28 studies","volume":"18","author":"Veltman-Verhulst","year":"2012","journal-title":"Hum Reprod Update"},{"key":"R22-20230916","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2147\/PPA.S119180","article-title":"Quality of life in overweight (obese) and normal-weight women with polycystic ovary syndrome","volume":"11","author":"Panico","year":"2017","journal-title":"Patient Prefer Adherence"},{"key":"R23-20230916","doi-asserted-by":"crossref","first-page":"112091","DOI":"10.1016\/j.jep.2019.112091","article-title":"Integrative Chinese herbal medicine therapy reduced the risk of type 2 diabetes mellitus in patients with polycystic ovary syndrome: a nationwide matched cohort study","volume":"243","author":"Liao","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"R24-20230916","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1142\/S0192415X17500252","article-title":"Chinese herbal medicine for the optimal management of polycystic ovary syndrome","volume":"45","author":"Ong","year":"2017","journal-title":"Am J Chin Med"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000022982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T03:19:57Z","timestamp":1694834397000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000022982"}},"subtitle":["A systematic review and meta-analysis protocol"],"short-title":[],"issued":{"date-parts":[[2020,12,4]]},"references-count":22,"journal-issue":{"issue":"49","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000022982","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,4]]}}}