{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:27:37Z","timestamp":1762900057577,"version":"3.40.4"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Talent Innovation and Entrepreneurship Project of Lanzhou city","award":["2017-RC-8"],"award-info":[{"award-number":["2017-RC-8"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Alzheimer disease (AD) is a progressive neurodegenerative disease characterized by impaired memory and cognitive judgment. It is the leading cause of dementia in the elderly, and its high morbidity and mortality have also brought a significant social burden. So far, there is no method can completely cure Alzheimer's dementia, but there are many non-drug treatments that have been praised by people, especially the cognitive behavioral therapy proposed in recent years. The main purpose of this article is to evaluate the effect of cognitive behavioral therapy on the cognitive function improvement of patients with Alzheimer's dementia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We did a network meta-analysis to identify both direct and indirect evidence in relevant studies. A systematic literature search will be performed in the Cochrane Library, PubMed, and EMBASE from inception to October 2020. We extracted the relevant information from these trials with a predefined data extraction sheet and assessed the risk of bias with the Cochrane risk of bias tool.<\/jats:p>\n            <jats:p>The outcomes investigated were Mini\u2013Mental State Examination and AD Assessment Scale-Cognitive section scores. We did a pair-wise meta-analysis using the fixed-effects model and then did a random-effects network meta-analysis within a Bayesian framework. The = the Assessment of Multiple Systematic Reviews-2 scale, Preferred Reporting Items for Systematic Reviews and Meta-Analyses scale and Grading of Recommendations Assessment, Development and Evaluation were used to assess the quality and evidence grade of the literature. General characteristics of the eligible randomized controlled trials will be summarized and described. Meanwhile, The ADDIS software will be used to perform the network meta-analysis, and the result figures will be generated by STATA 15.0 software.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Using the draft search strategy of databases and after screening,7 randomized controlled trials met the a priori criteria and were included. This network mate-analysis will be published in a peer-reviewed journal.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Our study will provide evidence for cognitive behavioral intervention in AD patients. And provide recommendations and guidelines for the clinic.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Protocol Registration:<\/jats:title>\n            <jats:p>INPLASY2020110052.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000023945","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:33:51Z","timestamp":1610584431000},"page":"e23945","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Whether cognitive behavioral therapy is effective for Alzheimer's disease"],"prefix":"10.1097","volume":"100","author":[{"given":"Wan-Qiang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, The First Hospital of Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Fang","family":"Wu","sequence":"additional","affiliation":[{"name":"Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, Gansu Province"},{"name":"WHO Collaborating Center for Guideline Implementation and Knowledge Translation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Bo","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Sleep, The Third Peoples Hospital of Lan Zhou, Lanzhou, Gansu, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ting","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Hospital of Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Hospital of Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Hospital of Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Gui","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Hospital of Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Qin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Hospital of Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"R1-20250504","first-page":"83","article-title":"Amyloid beta directed antibody for Alzheimer's disease, an evidence based meta-analysis","volume":"62","author":"Li","year":"2016","journal-title":"Cell Mol Biol"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jalz.2013.02.003","article-title":"Alzheimer's disease facts and figures","volume":"9","year":"2013","journal-title":"Alzheimers Dement"},{"key":"R4-20250504","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/bmj.39408.481898.BE","article-title":"Community occupational therapy for older patients with dementia and their care givers: cost effectiveness study","volume":"336","author":"Graff","year":"2008","journal-title":"BMJ"},{"key":"R5-20250504","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nrd3505","article-title":"The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics","volume":"10","author":"Karran","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"R6-20250504","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJMoa1304839","article-title":"Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease","volume":"370","author":"Salloway","year":"2014","journal-title":"N Engl J Med"},{"key":"R7-20250504","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13195-016-0189-7","article-title":"Bapineuzumab for mild to moderate Alzheimer's disease in two global, randomized, phase 3 trials","volume":"8","author":"Vandenberghe","year":"2016","journal-title":"Alzheimers Res Ther"},{"key":"R8-20250504","first-page":"CD013069","article-title":"Cognitive training for people with mild to moderate dementia","volume":"3","author":"Bahar-Fuchs","year":"2019","journal-title":"Cochrane Database Sys Rev"},{"key":"R9-20250504","doi-asserted-by":"crossref","first-page":"F8","DOI":"10.1136\/archdischild-2018-315224","article-title":"Network meta-analysis explained","volume":"104","author":"Dias","year":"2019","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"R10-20250504","doi-asserted-by":"crossref","first-page":"e010919","DOI":"10.1136\/bmjopen-2015-010919","article-title":"Comparative efficacy and acceptability of first-generation and second-generation antidepressants in the acute treatment of major depression: protocol for a network meta-analysis","volume":"6","author":"Furukawa","year":"2016","journal-title":"BMJ open"},{"key":"R11-20250504","doi-asserted-by":"crossref","first-page":"e018175","DOI":"10.1136\/bmjopen-2017-018175","article-title":"Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy","volume":"7","author":"Ge","year":"2017","journal-title":"BMJ open"},{"key":"R12-20250504","first-page":"i4086","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"354","year":"2016","journal-title":"BMJ"},{"key":"R13-20250504","first-page":"695","article-title":"Buschert Hans-Georg Buchholz","volume":"25","author":"Stefan","year":"2011","journal-title":"Journal of Alzheimer's Disease"},{"key":"R14-20250504","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1044\/1092-4388(2004\/085)","article-title":"Effects of cognitive-communication stimulation for Alzheimer's disease patients treated with donepezil, Journal of Speech","volume":"47","author":"Chapman","year":"2004","journal-title":"Language, and Hearing Research"},{"key":"R15-20250504","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/00006842-200205000-00016","article-title":"Assessing quality of life in older adults with cognitive impairment","volume":"64","author":"Logsdon","year":"2002","journal-title":"Psychosom Med"},{"key":"R16-20250504","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/13607860801919850","article-title":"A European consensus on outcome measures for psychosocial intervention research in dementia care","volume":"12","author":"Moniz-Cook","year":"2008","journal-title":"Aging Ment Health"},{"key":"R17-20250504","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1037\/h0037562","article-title":"The measurement of pessimism: the hopelessness scale","volume":"42","author":"Beck","year":"1987","journal-title":"J Consult Clin Psychol"},{"key":"R18-20250504","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/ane.12564","article-title":"Anxiety in Multiple Sclerosis: psychometric properties of the State-Trait Anxiety Inventory","volume":"134","author":"Santangelo","year":"2016","journal-title":"Acta Neurol Scand"},{"key":"R19-20250504","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00003727-198811000-00008","article-title":"Assessing social networks among elderly populations","volume":"11","author":"Lubben","year":"1988","journal-title":"Family & Community Health"},{"key":"R20-20250504","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s10072-017-3003-9","article-title":"Cognitive training in Alzheimer's disease: a controlled randomized study","volume":"38","author":"Giovagnoli","year":"2017","journal-title":"Neurol Sci"},{"key":"R21-20250504","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1067\/mem.2001.114903","article-title":"Diagnosing acute cardiac ischemia in the emergency department: a systematic review of the accuracy and clinical effect of current technologies","volume":"37","author":"Lau","year":"2001","journal-title":"Ann Emerg Med May"},{"key":"R22-20250504","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"R23-20250504","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"R24-20250504","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.healthpol.2014.09.002","article-title":"The reporting characteristics and methodological quality of Cochrane reviews about health policy research","volume":"119","author":"Li","year":"2015","journal-title":"Health Policy"},{"key":"R25-20250504","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/sim.3767","article-title":"Checking consistency in mixed treatment comparison meta-analysis","volume":"29","author":"Dias","year":"2010","journal-title":"Stat Med"},{"key":"R26-20250504","first-page":"112","article-title":"Tutorial of the probabilistic methods Bayesian networks and influence diagrams applied to medicine","author":"Beatriz","year":"2018","journal-title":"J Evid Based Med"},{"key":"R27-20250504","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12877-018-0864-6","article-title":"Psychosocial interventions for Alzheimer's disease cognitive symptoms: a Bayesian network meta-analysis","volume":"18","author":"Yu ting","year":"2018","journal-title":"BMC Geriatrics"},{"key":"R28-20250504","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jclinepi.2016.07.001","article-title":"The skills and experience of GRADE methodologists can be assessed with a simple tool","volume":"79","author":"Norris","year":"2016","journal-title":"J Clin Epidemiol"},{"key":"R29-20250504","doi-asserted-by":"crossref","first-page":"g5630","DOI":"10.1136\/bmj.g5630","article-title":"A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis","volume":"349","author":"Puhan","year":"2014","journal-title":"BMJ"},{"key":"R30-20250504","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jclinepi.2017.12.021","article-title":"Reporting of declarations and conflicts of interest in WHO guidelines can be further improved","volume":"98","author":"Wang","year":"2018","journal-title":"J Clin Epidemiol"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000023945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T06:26:06Z","timestamp":1746339966000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000023945"}},"subtitle":["A protocol for systematic review and network meta-analysis"],"short-title":[],"issued":{"date-parts":[[2021,1,8]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000023945","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"type":"print","value":"0025-7974"},{"type":"electronic","value":"1536-5964"}],"subject":[],"published":{"date-parts":[[2021,1,8]]},"assertion":[{"value":"2020-11-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}