{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T20:26:13Z","timestamp":1751919973675,"version":"3.41.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100011892","name":"Kaohsiung Chang Gung Memorial Hospital","doi-asserted-by":"crossref","award":["CMRPG8K0571 and CMRPG8K0572"],"award-info":[{"award-number":["CMRPG8K0571 and CMRPG8K0572"]}],"id":[{"id":"10.13039\/501100011892","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Adhesive small bowel obstruction (ASBO) is one of the most common complications and is a major cause of re-admission after intra-abdominal surgery. The initial management of patients with ASBO is nonoperative treatment such as nil per os and decompression using a nasogastric tube. However, the ideal management of ASBO remains controversial.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This study will be a prospective, single-center, double-blind randomized controlled trial. Ninety two participants diagnosed with ASBO will be randomly assigned to either the verum or the sham laser acupuncture (SLA) group in a 1:1 ratio. All participants will undergo laser acupuncture (LA) or SLA once a day on 6 acupoints (LI4, PC6, ST25, ST36, CV4 and CV12) for 6 consecutive days after enrollment. The primary outcome measure will be the success rate of conservative treatment for ASBO. Secondary outcomes will be time to oral intake and length of hospital stay. The serum levels of lipase, amylase, cortisol, motilin, ghrelin, and intestinal fatty acid binding protein (I-FABP) will also be measured before intervention, on day 4, and on the day of discharge, respectively. Data will be analyzed by Chi-Squared test or t test between 2 groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objectives:<\/jats:title>\n            <jats:p>The aim of this protocol is to investigate the clinical efficacy of LA on ASBO.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration:<\/jats:title>\n            <jats:p>ClinicalTrials.gov Identifier: NCT04318821. Registered on 24 March 2020.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000025035","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T12:37:07Z","timestamp":1614775027000},"page":"e25035","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Effect of laser acupuncture on adhesive small bowel obstruction"],"prefix":"10.1097","volume":"100","author":[{"given":"Chun-Han","family":"Shih","sequence":"first","affiliation":[{"name":"Department of Chinese Medicine, Kaohsiung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Min","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Trauma, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei-Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine, Kaohsiung"},{"name":"Graduate Institute of Integrated Medicine, College of Chinese Medicine, Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-1088","authenticated-orcid":false,"given":"Chun-Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine, Kaohsiung"},{"name":"Graduate Institute of Integrated Medicine, College of Chinese Medicine, Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"R1-20250612","doi-asserted-by":"crossref","first-page":"f5588","DOI":"10.1136\/bmj.f5588","article-title":"Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis","volume":"347","author":"Ten Broek","year":"2013","journal-title":"BMJ"},{"key":"R2-20250612","first-page":"291","article-title":"Adhesive small bowel obstruction: epidemiology, biology and prevention","volume":"50","author":"Attard","year":"2007","journal-title":"Can J Surg"},{"key":"R3-20250612","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13017-018-0185-2","article-title":"Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group","volume":"13","author":"Ten Broek","year":"2018","journal-title":"World J Emerg Surg"},{"key":"R4-20250612","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1097\/TA.0000000000000246","article-title":"Trials of nonoperative management exceeding 3\u200adays are associated with increased morbidity in patients undergoing surgery for uncomplicated adhesive small bowel obstruction","volume":"76","author":"Keenan","year":"2014","journal-title":"J Trauma Acute Care Surg"},{"key":"R5-20250612","doi-asserted-by":"crossref","first-page":"3178472","DOI":"10.1155\/2018\/3178472","article-title":"Acupuncture and related therapies for treatment of postoperative ileus in colorectal cancer: a systematic review and meta-analysis of randomized controlled trials","volume":"2018","author":"Liu","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"key":"R6-20250612","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/lsm.22423","article-title":"Prevention of abdominal adhesions and healing skin after peritoniectomy using low level laser","volume":"47","author":"Teixeira","year":"2015","journal-title":"Lasers Surg Med"},{"key":"R7-20250612","first-page":"253","article-title":"Side effects of hyperbaric oxygen therapy","volume":"41","author":"Camporesi","year":"2014","journal-title":"Undersea Hyperbaric Med"},{"key":"R9-20250612","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1001\/jamasurg.2018.5248","article-title":"Association of surgical intervention for adhesive small-bowel obstruction with the risk of recurrence","volume":"154","author":"Behman","year":"2019","journal-title":"JAMA Surg"},{"key":"R10-20250612","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/TA.0000000000002196","article-title":"Outcomes in adhesive small bowel obstruction from a large statewide database: what to expect after nonoperative management","volume":"86","author":"Wessels","year":"2019","journal-title":"J Trauma Acute Care Surg"},{"key":"R11-20250612","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4240\/wjgs.v8.i3.222","article-title":"Adhesive small bowel adhesions obstruction: Evolutions in diagnosis,1; 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