{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:58:43Z","timestamp":1778126323186,"version":"3.51.4"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","license":[{"start":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:00:00Z","timestamp":1620950400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Rationale:<\/jats:title>\n            <jats:p>Coronavirus disease 2019 (COVID-19) has spread worldwide. It involves multiple organs of infected individuals and encompasses diverse clinical manifestations. We report a case of acute optic neuritis (ON) associated with myelin oligodendrocyte glycoprotein (MOG) antibody possibly induced by COVID-19.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patient concerns:<\/jats:title>\n            <jats:p>A 47-year-old man presented to our clinic with left eye pain and vision loss. Magnetic resonance imaging of the orbit revealed the bilateral high intensity of the optic nerve sheaths. He tested positive for COVID-19 by polymerase chain reaction (PCR) testing on the day of admission but he had no signs of respiratory illness. Laboratory testing revealed that MOG immunoglobulin G (MOG IgG) was positive, but other antibodies including aquaporin-4 were negative.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Diagnosis:<\/jats:title>\n            <jats:p>The patient was diagnosed with MOG antibody-positive acute ON possibly induced by COVID-19.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interventions:<\/jats:title>\n            <jats:p>Steroid pulse therapy consisting of methylprednisolone 1\u200ag\/day for a total of 3\u200adays, followed by an oral prednisolone taper was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Outcomes:<\/jats:title>\n            <jats:p>His left eye pain was immediately relieved, and his decimal vision improved from 0.03 to 0.1 on the day of discharge. Outpatient follow-up 2\u200aweeks later revealed left a decimal vision of 1.2, and a complete resolution of the left eye pain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Lessons:<\/jats:title>\n            <jats:p>Our case indicated that COVID-19 might trigger an autoimmune response that leads to MOG antibody-associated ON, similar to other pathogens that were reported in the past. The treatment response to steroid pulse therapy was preferable following a typical course of MOG antibody-positive ON.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000025865","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T20:02:46Z","timestamp":1620763366000},"page":"e25865","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":44,"title":["Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis in a COVID-19 patient"],"prefix":"10.1097","volume":"100","author":[{"given":"Chio","family":"Kogure","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Yamanashi, Chuo, Yamanashi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2548-3806","authenticated-orcid":false,"given":"Wataru","family":"Kikushima","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Yamanashi, Chuo, Yamanashi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Yamanashi, Chuo, Yamanashi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Hasebe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Yamanashi, Chuo, Yamanashi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi"},{"name":"Department of Neurology, National Hospital Organization Yonezawa National Hospital, Yonezawa, Yamagata"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Shibuya Eye Clinic, Fujikawa, Yamanashi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Sakurada","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Yamanashi, Chuo, Yamanashi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Yamanashi, Chuo, Yamanashi"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,5,14]]},"reference":[{"key":"R1-20250504","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/jamacardio.2020.1096","article-title":"Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19)","volume":"5","author":"Inciardi","year":"2020","journal-title":"JAMA Cardiol"},{"key":"R4-20250504","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1021\/acschemneuro.0c00122","article-title":"Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms","volume":"11","author":"Baig","year":"2020","journal-title":"ACS Chem Neurosci"},{"key":"R5-20250504","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jmv.25728","article-title":"The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients","volume":"92","author":"Li","year":"2020","journal-title":"J Med Virol"},{"key":"R6-20250504","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijid.2020.03.062","article-title":"A first case of meningitis\/encephalitis associated with SARS-Coronavirus-2","volume":"94","author":"Moriguchi","year":"2020","journal-title":"Int J Infect Dis"},{"key":"R7-20250504","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1212\/WNL.0000000000009700","article-title":"COVID-19 presenting with ophthalmoparesis from cranial nerve palsy","volume":"95","author":"Dinkin","year":"2020","journal-title":"Neurology"},{"key":"R8-20250504","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/09273948.2020.1738501","article-title":"Can the coronavirus disease 2019 (COVID-19) affect the eyes? 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