{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:48:38Z","timestamp":1788522518549,"version":"build-2803163510"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"41","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Gensini score (GS) provides valuable information on severity and prognosis of coronary artery disease (CAD).<\/jats:p>\n            <jats:p>To evaluate the relationship between the severity of CAD determined by the GS and relation to ST-elevation myocardial infarction, non-ST segment elevation myocardial infarction (NSTEMI), unstable angina pectoris, chest pain (suspected angina syndrome on admission) and risk-factors for CAD and predictors of severity.<\/jats:p>\n            <jats:p>Observational cross-sectional study.<\/jats:p>\n            <jats:p>Consecutive patients who underwent clinically-indicated coronary angiography for ST-elevation myocardial infarction, NSTEMI, unstable angina pectoris or chest pain were enrolled.<\/jats:p>\n            <jats:p>Among 600 patients, 417 (average age 67.8\u200a\u00b1\u200a12.2\u200ayears) had CAD\u2013related symptoms. Mean GS was 66.7\u200a\u00b1\u200a63.8. Patients presenting with NSTEMI had the highest GS (81.3\u200a\u00b1\u200a42.3; <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a.001) Regression analysis of risk-factors showed the best association of GS with multivessel disease and coronary artery bypass graft. Regression analysis of medications showed that clopidogrel, had the best association with low GS.<\/jats:p>\n            <jats:p>GS correlated with the severity of CAD, multivessel disease, coronary artery bypass graft, and troponin. GS was related to the cardiovascular risk-factors of diabetes, hypertension, and high-density cholesterol.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000027331","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T22:27:30Z","timestamp":1637706450000},"page":"e27331","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":32,"title":["Using the Gensini score to estimate severity of STEMI, NSTEMI, unstable angina, and anginal syndrome"],"prefix":"10.1097","volume":"100","author":[{"given":"Lior","family":"Charach","sequence":"first","affiliation":[{"name":"Meir Medical Center, Kfar Saba, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Blatt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kaplan Medical Center, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jonas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kaplan Medical Center, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Teodorovitz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kaplan Medical Center, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Haberman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kaplan Medical Center, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gera","family":"Gendelman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kaplan Medical Center, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itamar","family":"Grosskopf","sequence":"additional","affiliation":[{"name":"Meir Medical Center, Kfar Saba, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kaplan Medical Center, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-9889","authenticated-orcid":false,"given":"Gideon","family":"Charach","sequence":"additional","affiliation":[{"name":"Meir Medical Center, Kfar Saba, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ahj.2012.07.007","article-title":"Coronary angiographic scoring systems: an evaluation of their equivalence and validity","volume":"164","author":"Neeland","year":"2012","journal-title":"Am Heart J"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2147\/CIA.S3551","article-title":"Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: a hospital-based, prospective study in Greek patients","volume":"3","author":"Peppes","year":"2008","journal-title":"Clin Interv Aging"},{"key":"R4-20250504","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM197906143002402","article-title":"Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease","volume":"300","author":"Diamond","year":"1979","journal-title":"N Engl J Med"},{"key":"R5-20250504","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1161\/01.CIR.64.2.360","article-title":"Angiographic prevalence of high-risk coronary artery disease in patient subsets (CASS)","volume":"64","author":"Chaitman","year":"1981","journal-title":"Circulation"},{"key":"R6-20250504","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1161\/01.CIR.33.6.901","article-title":"Selective cine coronary arteriography: correlation with clinical findings in 1,000 patients","volume":"33","author":"Proudfit","year":"1966","journal-title":"Circulation"},{"key":"R7-20250504","doi-asserted-by":"crossref","first-page":"E36","DOI":"10.25011\/cim.v33i1.11836","article-title":"The assessment of atherosclerosis on vascular structures in patients with acute coronary syndrome","volume":"33","author":"Kalay","year":"2010","journal-title":"Clin Invest Med"},{"key":"R8-20250504","first-page":"388","article-title":"The relationship of Gensini score with the cardiovascular risk of patients with indication of angiography","volume":"69","author":"Mohagheghi","year":"2011","journal-title":"Tehran Univ Med J"},{"key":"R9-20250504","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/clc.22151","article-title":"Presence of angina pectoris is related to extensive coronary artery disease in diabetic patients","volume":"36","author":"Celik","year":"2013","journal-title":"Clin Cardiol"},{"key":"R10-20250504","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/med\/9780199566990.003.014","article-title":"Diabetes mellitus and metabolic syndrome","author":"Cosentino","year":"2009","journal-title":"ESC Textbook of Cardiovascular Medicine"},{"key":"R11-20250504","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1001\/jama.1979.03290450033020","article-title":"Diabetes and cardiovascular disease: the Framingham study","volume":"241","author":"Kannel","year":"1979","journal-title":"JAMA"},{"key":"R12-20250504","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/0735-1097(92)90033-J","article-title":"Acute myocardial infarction in the diabetic patient: pathophysiology, clinical course and prognosis","volume":"20","author":"Jacoby","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"R13-20250504","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7326\/0003-4819-118-2-199301150-00001","article-title":"Value of the history and physical in identifying patients at increased risk for coronary artery disease","volume":"118","author":"Pryor","year":"1993","journal-title":"Ann Intern Med"},{"key":"R14-20250504","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00392-013-0555-4","article-title":"Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application","volume":"102","author":"Sinning","year":"2013","journal-title":"Clin Res Cardiol"},{"key":"R15-20250504","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0002-9149(83)80105-2","article-title":"A more meaningful scoring system for determining the severity of coronary heart disease","volume":"51","author":"Gensini","year":"1983","journal-title":"Am J Cardiol"},{"key":"R16-20250504","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.amjcard.2010.11.020","article-title":"Sex, clinical symptoms, and angiographic findings in patients with diabetes mellitus and coronary artery disease (from the Bypass Angioplasty Revascularization Investigation [BARI] 2 Diabetes trial)","volume":"107","author":"Tamis-Holland","year":"2011","journal-title":"Am J Cardiol"},{"key":"R17-20250504","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1161\/01.CIR.99.21.2829","article-title":"ACC\/AHA\/ACPASIM guidelines for the management of patients with chronic stable angina: executive summary and recommendations. A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients with Chronic Stable Angina)","volume":"99","author":"Gibbons","year":"1999","journal-title":"Circulation"},{"key":"R18-20250504","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1191\/096120300678828190","article-title":"Autoimmunity in atherosclerosis: lessons from experimental models","volume":"9","author":"George","year":"2000","journal-title":"Lupus"},{"key":"R19-20250504","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4236\/ojim.2012.23025","article-title":"The relation between differential leukocyte count, neutrophil to lymphocyte ratio and the presence and severity of coronary artery disease","volume":"2","author":"Selcuk","year":"2012","journal-title":"Open J Intern Med"},{"key":"R20-20250504","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5543\/tkda.2013.26235","article-title":"Mean platelet volume and the extent of coronary atherosclerosis in patients with stable coronary artery disease","volume":"41","author":"Karan","year":"2013","journal-title":"Turk Kardiyol Dern Ars"},{"key":"R21-20250504","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/1076029613485283","article-title":"Carotid intima-media thickness in patients with slow coronary flow and its association with neutrophil-to-lymphocyte ratio: a preliminary report","volume":"20","author":"Cingoz","year":"2014","journal-title":"Clin Appl Thromb Hemost"},{"key":"R22-20250504","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.amjcard.2010.12.049","article-title":"Usefulness of total lymphocyte count as predictor of outcome in patients with chronic heart failure","volume":"107","author":"Charach","year":"2011","journal-title":"Am J Cardiol"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000027331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T04:39:08Z","timestamp":1746333548000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000027331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":21,"journal-issue":{"issue":"41","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000027331","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,15]]},"assertion":[{"value":"2021-04-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}