{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:24:44Z","timestamp":1785860684750,"version":"3.56.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"49","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81774402"],"award-info":[{"award-number":["81774402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Adenomyosis (AM) is a disease in which the endometrium (including glands and stroma) invades the myometrium and grows. The main clinical symptoms include menorrhagia, dysmenorrhea, chronic pelvic pain, metrorrhagia, and dyspareunia, which will seriously affect the physical and mental health of patients, and most of which occur in women of childbearing age. Acupuncture, as a special external treatment of Traditional Chinese medicine, has shown good effects in the treatment of adenomyosis. At present, there is a lack of systematic review on acupuncture in the treatment of adenomyosis. We conduct this study to evaluate the efficacy and safety of acupuncture in the treatment of adenomyosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We will search Chinese and English databases: Medline, Pubmed, EMBASE, Cochrane library, China National Knowledge Infrastructure (CNKI), Chinese Scientific and Journal Database, Wan Fang database (Wanfang), Chinese Biomedical Literature Database (CBM) to identify articles of randomized clinical trials of acupuncture for adenomyosis. All above electronic databases will be searched from inception to September 30, 2021. RevMan 5.3 software will be used to conduct this systematic review. No language and publication status restrictions will be applied.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The study will prove the efficacy and safety of acupuncture for adenomyosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We plan to submit this systematic review to a peer-reviewed journal.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration number<\/jats:title>\n            <jats:p>CRD42021277136.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000028080","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T13:06:43Z","timestamp":1639141603000},"page":"e28080","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of acupuncture for adenomyosis"],"prefix":"10.1097","volume":"100","author":[{"given":"Jingru","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tairan","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"R1-20250504","first-page":"376","article-title":"Expert consensus on diagnosis and treatment of adenomyosis in China [J]","volume":"55","year":"2020","journal-title":"Chin J Obstetr Gynecol"},{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.rbmo.2017.06.016","article-title":"Pathogenesis of adenomyosis: an update on molecular mechanisms","volume":"35","author":"Vannuccini","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/uog.19096","article-title":"Sonographic classification and reporting system for diagnosing adenomyosis [J]","volume":"53","author":"Van den Bosch","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"key":"R4-20250504","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2012.06.027","article-title":"Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification [J]","volume":"207","author":"Kishi","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"R5-20250504","doi-asserted-by":"crossref","DOI":"10.1186\/s13244-019-0732-8","article-title":"Management of uterine adenomyosis: current trends and uterine artery embolization as a potential alternative to hysterectomy","volume":"10","author":"Dessouky","year":"2019","journal-title":"Insights Imaging"},{"key":"R6-20250504","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jmig.2015.09.018","article-title":"Adenomyosis: a clinical review of a challenging gynecologic condition","volume":"23","author":"Struble","year":"2016","journal-title":"J Minim Invasive Gynecol"},{"issue":"(O1)","key":"R7-20250504","first-page":"74","article-title":"Conservative surgical treatment of adenomyosis: a review [J]","author":"Zhang Yingying","year":"2008","journal-title":"Chin Obstetr Gynecol"},{"key":"R8-20250504","first-page":"896","article-title":"Treatment of diffuse adenomyosis with uterine artery embolization [J]","volume":"22","author":"Yao Qunli","year":"2013","journal-title":"J Intervent Radiol"},{"key":"R9-20250504","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/14728222.2016.1180368","article-title":"Selective progesterone receptor modulator (SPPMS): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological therapies [J]","volume":"20","author":"Wagenfeld","year":"2016","journal-title":"Expert Opin Ther targets"},{"key":"R10-20250504","first-page":"157","article-title":"Principles and precautions of drug therapy for adenomyosis [J]","volume":"33","author":"Zhou","year":"2017","journal-title":"J Appl Gynecol Obstetr"},{"key":"R11-20250504","first-page":"12","article-title":"Status and progress of nonoperative treatment for adenomyosis [J]","volume":"6","author":"Tian Ying","year":"2019","journal-title":"J Pract Gynecol Endocrinol"},{"key":"R12-20250504","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000028080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T05:08:07Z","timestamp":1746335287000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000028080"}},"subtitle":["A protocol for systematic review and meta-analysis"],"short-title":[],"issued":{"date-parts":[[2021,12,10]]},"references-count":12,"journal-issue":{"issue":"49","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000028080","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,10]]},"assertion":[{"value":"2021-11-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}