{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:59:11Z","timestamp":1758394751945,"version":"3.40.4"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"51","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Rationale:<\/jats:title>\n            <jats:p>Gastric-type endocervical adenocarcinoma (GAS) is a rare type of cervical adenocarcinoma that is a mucinous adenocarcinoma with a variety of gastral patterns. To date, there are no systematic clinical diagnosis and treatment guidelines.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patient concerns:<\/jats:title>\n            <jats:p>In our case, a 49-year-old woman underwent pelvic magnetic resonance imaging (MRI) due to a pelvic mass, and cervical lesions were unexpectedly found. After receiving relevant surgical treatment, the pathological results showed the particularity of the tumor type\u2014cervical gastric adenocarcinoma with a borderline serous tumor of both appendages and the right ovary.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Diagnoses:<\/jats:title>\n            <jats:p>Postoperative routine pathological examination showed mucoepithelial metaplasia accompanied by a borderline serous tumor.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interventions:<\/jats:title>\n            <jats:p>After gynecological\/urinary ultrasound, blood tests, MRI, cervical biopsy, and uterine curettage, \u201crobot-assisted laparoscopic radical hysterectomy + bilateral salpingectomy-ovariectomy + pelvic lymph node dissection + pelvic adhesiolysis\u201d were performed. After the surgery, the patient was treated with radiotherapy and concurrent chemotherapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Outcomes:<\/jats:title>\n            <jats:p>After the operation, radiotherapy, and chemotherapy, the patient had no tumor recurrence and is still in good condition.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Lessons:<\/jats:title>\n            <jats:p>The diagnosis of GAS is relatively difficult, its clinical manifestations lack specificity, and the pathogenesis has nothing to do with human papillomavirus infection. The patient was misdiagnosed with vaginitis at a local hospital. However, we found that MRI and pathological examination were helpful for the diagnosis of the disease. Although there are no relevant guidelines to explain the treatment principles of GAS, we believe that early surgery is conducive to the prognosis of the disease because GAS has a certain tolerance to radiotherapy and chemotherapy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000028239","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T14:37:49Z","timestamp":1640270269000},"page":"e28239","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Gastric-type endocervical adenocarcinoma with mucoepithelial metaplasia combined with a serous borderline tumor"],"prefix":"10.1097","volume":"100","author":[{"given":"Man","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Jining Medical University, Jining, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jining Medical University, Jining, Shandong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1371-278X","authenticated-orcid":false,"given":"Yunfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jining Medical University, Jining, Shandong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"R1-20250504","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/S2214-109X(19)30482-6","article-title":"Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis","volume":"8","author":"Arbyn","year":"2020","journal-title":"Lancet Glob Health"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"198016","DOI":"10.1016\/j.virusres.2020.198016","article-title":"Human papillomavirus-related cancers and mitochondria","volume":"286","author":"Cruz-Gregorio","year":"2020","journal-title":"Virus Res"},{"key":"R4-20250504","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0140-6736(20)30157-4","article-title":"Mortality impact of achieving WHO cervical cancer elimination targets: a comparative modelling analysis in 78 low-income and lower-middle-income countries","volume":"395","author":"Canfell","year":"2020","journal-title":"Lancet"},{"key":"R5-20250504","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/01.pas.0000213434.91868.b0","article-title":"Gastric morphology and immunophenotype predict poor outcome in mucinous adenocarcinoma of the uterine cervix","volume":"31","author":"Kojima","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"R7-20250504","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/PAS.0000000000000986","article-title":"International Endocervical Adenocarcinoma Criteria and Classification (IECC): a new pathogenetic classification for invasive adenocarcinomas of the endocervix","volume":"42","author":"Stolnicu","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"R8-20250504","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ygyno.2019.01.022","article-title":"Analysis of gastric-type mucinous carcinoma of the uterine cervix - 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