{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:18:43Z","timestamp":1778800723391,"version":"3.51.4"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"51","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"tianjin nursing association","award":["tjhlky2019YB02"],"award-info":[{"award-number":["tjhlky2019YB02"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>We aimed to explore the methods to reduce or prevent nasal complications after endoscopic transsphenoidal pituitary adenoma resection. We also examined the effects of nasal irrigation after this procedure was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A randomized controlled trial was performed. Sixty patients of a tertiary hospital were enrolled in this study. The subjects were randomly divided into a control group and an intervention group. The subjects of the control group were given routine guidance, and 20\u200amL of normal saline was atomized through inhalation. The gauze was removed 7\u200adays after surgery. The patients of the intervention group were given 50\u200amL of a 2% saline solution at 37\u00b0C to 38\u00b0C for bilateral nasal irrigation for 1 week. After that, patients were given 50\u200amL of a 0.9% normal saline solution at 37\u00b0C to 38\u00b0C for bilateral nasal irrigations. The complications of the two groups were collected at baseline, 1\u200aweek after intervention, 1\u200amonth, and 3\u200amonths after intervention. The data were analyzed using the chi-square test.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A 1-month after intervention, there were significant differences in dysosmia, epistaxis, and nasal adhesion between the intervention and control groups. A 3-month after intervention, only olfactory disturbances were significantly different between the two groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Nasal irrigation helps reduce the incidence of complications such as epistaxis and nasal adhesions in the early postoperative period. It can also promote the elimination or reduction of olfactory disturbances.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000028317","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T19:13:02Z","timestamp":1640286782000},"page":"e28317","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Effects of nasal irrigation after endoscopic transsphenoidal resection in patients with pituitary adenomas"],"prefix":"10.1097","volume":"100","author":[{"given":"Peng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Tianjin Huanhu Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China"},{"name":"Department of Nursing Management, Tianjin Huanhu Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Operating Room, Tianjin Huanhu Hospital, Tianjin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Tianjin Huanhu Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Tianjin Huanhu Hospital, Tianjin, 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Otorhinolaryngol Head Neck Surg"},{"key":"R5-20250504","first-page":"487","article-title":"Expert consensus on the diagnosis and treatment of olfactory disorders (2017)","volume":"53","year":"2018","journal-title":"Chin J Otorhinolaryngol Head Neck Surg"},{"key":"R6-20250504","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.3171\/jns.2001.95.6.1083","article-title":"The history and evolution of transsphenoidal surgery[J]","volume":"95","author":"Liu","year":"2001","journal-title":"J Neurosurg"},{"key":"R7-20250504","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0960-7404(97)00008-X","article-title":"Pituitary tumors: surgical and medical management[J]","volume":"6","author":"Yeh","year":"1997","journal-title":"Surg Oncol"},{"key":"R8-20250504","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1023\/A:1012969719503","article-title":"Endoscopic transsphenoidal surgery(J)","volume":"54","author":"Jho","year":"2001","journal-title":"J 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resection","volume":"9","author":"Cheng You","year":"2017","journal-title":"Chin Otorhinolaryngol Head Neck Surg"},{"key":"R13-20250504","first-page":"144","article-title":"Analysis of the clinical application effect of nasal cavity irrigation nursing in functional endoscopic sinus surgery","volume":"8","author":"Dong Hongli","year":"2018","journal-title":"Chin Health Stand Manage"},{"key":"R14-20250504","first-page":"81","article-title":"Evaluation of the effect of comfort care in patients with nasal surgery","volume":"13","author":"Chen Wenxia","year":"2016","journal-title":"Chin Med Innov"},{"key":"R15-20250504","first-page":"1329","article-title":"Comparison of the effect of low-concentration and high-concentration saline for nasal irrigation after nasal endoscopic surgery","volume":"24","author":"Xu Ying","year":"2015","journal-title":"Mod J Integr Tradit Chin West Med"},{"key":"R16-20250504","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3171\/jns.2003.98.2.0350","article-title":"Endonasal transsphenoidal approach for pituitary adenomas and other sellar lesions an assessment of efficacy, safety, and patient impressions","volume":"98","author":"Zada","year":"2003","journal-title":"J Neurosurg"},{"key":"R17-20250504","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.surneu.2005.12.010","article-title":"Endonasal transsphenoidal surgery: the patient's perspective-survey results from 259 patients","volume":"65","author":"Dusick","year":"2006","journal-title":"Surg Neurol"},{"key":"R18-20250504","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/194589240501900212","article-title":"Isolated sphenoid sinusitis after transsphenoidal hypophysectomy","volume":"19","author":"Batra","year":"2005","journal-title":"Am J Rhinol"},{"key":"R19-20250504","first-page":"192","article-title":"Efficacy analysis of pituitary tumor resection through different approaches","volume":"23","author":"Jia Yongjun","year":"2015","journal-title":"Chin J Clin Neurol"},{"key":"R20-20250504","first-page":"327","article-title":"The effect of different nasal cavity irrigation methods on the efficacy and application value of endoscopic sinusitis in patients with sinusitis","volume":"30","author":"Cheng Yanbin","year":"2017","journal-title":"Chin Clin Res"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000028317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T06:06:24Z","timestamp":1746338784000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000028317"}},"subtitle":["A randomized controlled trial"],"short-title":[],"issued":{"date-parts":[[2021,12,23]]},"references-count":19,"journal-issue":{"issue":"51","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000028317","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,23]]},"assertion":[{"value":"2021-07-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}