{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:14:44Z","timestamp":1790810084799,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Although the distribution of arterial involvement is still the subject of controversy for defining the diagnostic criteria for thromboangiitis obliterans (TAO), several reports have described TAO involving the more proximal arterial segment. This study aimed to investigate the clinical characteristics and outcomes of large artery TAO in comparison with those of small artery TAO.<\/jats:p>\n            <jats:p>Between January 2007 and July 2019, 83 consecutive symptomatic patients with a diagnosis of lower extremity TAO were stratified according to the most proximal arterial involvement, with the cutoff level of the adductor canal as a reference (large artery TAO versus small artery TAO), and analyzed retrospectively. The study outcomes included any amputations and major amputations.<\/jats:p>\n            <jats:p>The large artery TAO group consisted of 30 patients (36.1%), and the small artery TAO group consisted of 53 patients (63.9%). In terms of clinical symptoms and signs, the proportion of major tissue loss (Rutherford class 6) was significantly higher among patients with large artery TAO than among those with small artery TAO (13.3% versus 0%, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.02). Any amputation rate was similar between the large and small artery TAO groups during the median follow-up period of 148\u200amonths (range, 0\u2013376\u200amonths) (43.3% versus 28.3%, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.16). However, the major amputation rate was significantly higher among patients with large artery TAO (13.3% versus 0%, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.02). On Kaplan\u2013Meier survival analysis of the cumulative event-free rates, although there was a similar 10-year amputation-free survival rate (<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a.24) between the 2 groups, the large artery TAO group had a significantly lower 10-year major amputation-free survival rate (<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a.01) than the small artery TAO group.<\/jats:p>\n            <jats:p>Large artery TAO is a limb-threatening condition and had a worse prognosis than small artery TAO.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000028512","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T13:16:54Z","timestamp":1641561414000},"page":"e28512","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Long-term outcomes of large artery thromboangiitis obliterans and comparison with small artery thromboangiitis obliterans"],"prefix":"10.1097","volume":"101","author":[{"given":"Sang Ah","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Jae","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Surgery, GangNeung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi-Young","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Sang","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Il","family":"Gwon","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eol","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Won","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0639-451X","authenticated-orcid":false,"given":"Yong-Pil","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"R1-20250504","doi-asserted-by":"crossref","first-page":"e010677","DOI":"10.1161\/JAHA.118.010677","article-title":"Long-term outcome and prognostic factors of complications in thromboangiitis obliterans (Buerger's disease): a multicenter study of 224 patients","volume":"7","author":"Le Joncour","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"(5 Suppl)","key":"R2-20250504","first-page":"IV3","article-title":"The changing clinical spectrum of thromboangiitis obliterans (Buerger's disease)","volume":"82","author":"Olin","year":"1990","journal-title":"Circulation"},{"key":"R3-20250504","first-page":"80","article-title":"Long-term follow-up of thromboangiitis obliterans","volume":"27","author":"B\u00f6rner","year":"1998","journal-title":"Vasa"},{"key":"R4-20250504","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1016\/j.jacc.2004.09.029","article-title":"Long-term survival and amputation risk in thromboangiitis obliterans (Buerger's disease)","volume":"44","author":"Cooper","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"(Suppl 1)","key":"R5-20250504","doi-asserted-by":"crossref","first-page":"S243","DOI":"10.1016\/S0167-5273(98)00175-2","article-title":"Diagnosis criteria of Buerger's disease","volume":"66","author":"Shionoya","year":"1998","journal-title":"Int J Cardiol"},{"key":"R6-20250504","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s005950070099","article-title":"Distribution of arterial involvement in thromboangiitis obliterans (Buerger's disease): results of a study conducted by the Intractable Vasculitis Syndromes Research Group in Japan","volume":"30","author":"Sasaki","year":"2000","journal-title":"Surg Today"},{"key":"R7-20250504","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.pathol.2017.06.008","article-title":"Multi-organ vaso-occlusive disease: Buerger's or Kohlmeier-Degos disease?","volume":"49","author":"Choo","year":"2017","journal-title":"Pathology"},{"key":"R8-20250504","first-page":"449","article-title":"Clinical, arteriographic and histopathologic analysis of 13 patients with thromboangiitis obliterans and coronary involvement","volume":"16","author":"Nobre","year":"2014","journal-title":"Isr Med Assoc J"},{"key":"R9-20250504","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3400\/avd.cr.14-00035","article-title":"Obstruction of the superior mesenteric artery due to emboli from the thoracic aorta in a patient with thromboangiitis obliterans","volume":"7","author":"Kamiya","year":"2014","journal-title":"Ann Vasc Dis"},{"key":"R10-20250504","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00595-004-2955-6","article-title":"Mesenteric involvement of acute-stage Buerger's disease as the initial clinical manifestation: report of a case","volume":"35","author":"Cho","year":"2005","journal-title":"Surg Today"},{"key":"R11-20250504","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s003800200023","article-title":"Involvement of the coronary artery in a patient with thromboangiitis obliterans. A case report","volume":"16","author":"Becit","year":"2002","journal-title":"Heart Vessel"},{"key":"R12-20250504","first-page":"325","article-title":"Buerger's disease with multisystem involvement. A case report and a review of the literature","volume":"55","author":"Calg\u00fcneri","year":"2004","journal-title":"Angiology"},{"key":"R13-20250504","first-page":"69","article-title":"Involvement of the iliac artery in Buerger's disease (pathogenesis and arterial reconstruction)","volume":"19","author":"Shionoya","year":"1978","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"R14-20250504","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1056\/NEJM198904203201608","article-title":"Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 16-1989. A 36-year-old man with peripheral vascular disease","volume":"320","year":"1989","journal-title":"N Engl J Med"},{"key":"R15-20250504","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1177\/096721099400200415","article-title":"Focal occlusive disease of the common femoral artery: a report of 20 cases","volume":"2","author":"Mandalam","year":"1994","journal-title":"Cardiovasc Surg"},{"key":"R16-20250504","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1177\/000331977302400605","article-title":"Thromboangiitis obliterans of the iliac artery. Report of two cases","volume":"24","author":"Abu-Dalu","year":"1973","journal-title":"Angiology"},{"key":"R17-20250504","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jvs.2003.08.006","article-title":"Clinical and social consequences of Buerger disease","volume":"39","author":"Ohta","year":"2004","journal-title":"J Vasc Surg"},{"key":"R18-20250504","doi-asserted-by":"crossref","first-page":"e0205305","DOI":"10.1371\/journal.pone.0205305","article-title":"Outcomes of endovascular treatment versus bypass surgery for critical limb ischemia in patients with thromboangiitis obliterans","volume":"13","author":"Lee","year":"2018","journal-title":"PLoS One"},{"key":"R19-20250504","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2214\/ajr.109.3.553","article-title":"Arteriographic findings in thromboangiitis obliterans with emphasis on femoropopliteal involvement","volume":"109","author":"Lambeth","year":"1970","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"R20-20250504","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/00000441-190810000-00011","article-title":"Thromboabgiitis obliterans: a study of the vascular lesions leading to pre-senile spontaneous gangrene","volume":"136","author":"Buerger","year":"1908","journal-title":"Am J Med Sci"},{"key":"R21-20250504","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00005792-198701000-00002","article-title":"Thromboangiitis obliterans (Buerger's disease) in women","volume":"66","author":"Lie","year":"1987","journal-title":"Medicine (Baltimore)"},{"key":"R22-20250504","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jvs.2017.03.425","article-title":"Outcomes of endovascular recanalization versus autogenous venous bypass for thromboangiitis obliterans patients with critical limb ischemia due to tibioperoneal arterial occlusion","volume":"66","author":"Ye","year":"2017","journal-title":"J Vasc Surg"},{"key":"R23-20250504","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0741-5214(03)00312-4","article-title":"Evaluating effects of method of administration on Walking Impairment Questionnaire","volume":"38","author":"Coyne","year":"2003","journal-title":"J Vasc Surg"},{"key":"R24-20250504","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jvs.2007.10.052","article-title":"Claudication distances and the Walking Impairment Questionnaire best describe the ambulatory limitations in patients with symptomatic peripheral arterial disease","volume":"47","author":"Myers","year":"2008","journal-title":"J Vasc Surg"},{"key":"R25-20250504","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1078-5884(98)80237-2","article-title":"Percutaneous transluminal angioplasty for intermittent claudication: evidence on which to base the medicine","volume":"16","author":"Chetter","year":"1998","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"R26-20250504","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S1078-5884(96)80081-5","article-title":"A point scoring system for the clinical diagnosis of Buerger's disease","volume":"11","author":"Papa","year":"1996","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"R27-20250504","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s00595-014-0904-6","article-title":"The fate of ischemic limbs in patients with Buerger's disease based on our 30-year experience: does smoking have a definitive impact on the late loss of limbs?","volume":"45","author":"Sugimoto","year":"2015","journal-title":"Surg Today"},{"key":"R28-20250504","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/1708538118805623","article-title":"Clinical outcomes of extended endovascular recanalization of 16 consecutive Buerger's disease patients","volume":"27","author":"Kacmaz","year":"2019","journal-title":"Vascular"},{"key":"R29-20250504","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/1538574417744085","article-title":"Endovascular treatment of thromboangiitis obliterans (Buerger's disease)","volume":"52","author":"Modaghegh","year":"2018","journal-title":"Vasc Endovascular Surg"},{"key":"R30-20250504","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.jvs.2017.09.020","article-title":"Immediate and late outcomes of endovascular therapy for lower extremity arteries in Buerger disease","volume":"67","author":"Kim","year":"2018","journal-title":"J Vasc Surg"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000028512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T04:11:36Z","timestamp":1746331896000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000028512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,7]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000028512","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,7]]},"assertion":[{"value":"2021-03-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}