{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:45:16Z","timestamp":1772131516916,"version":"3.50.1"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Rationale:<\/jats:title>\n            <jats:p>Hyperthyroidism, such as Basedow disease, causes fluid retention, although the common cause is volume overload due to congestive heart failure. In addition, hyperthyroidism and Basedow disease are known to cause pulmonary hypertension. Edematous thickening of the gallbladder wall is caused by venous blood congestion. The feature of edematous wall thickening of the gallbladder on abdominal computed tomography (CT) is subserosal edema and is often accompanied by a periportal collar sign.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patient concerns:<\/jats:title>\n            <jats:p>A 30-year-old woman was referred to our hospital because of liver dysfunction, edematous gallbladder wall thickening, and fluid retention. In addition, the patient developed hyperthyroidism and heart failure. Enhanced abdominal CT revealed edematous wall thickening of the gallbladder and a periportal collar sign.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Diagnosis:<\/jats:title>\n            <jats:p>We suspected that fluid retention and congestion were caused by hyperthyroidism and Basedow disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interventions:<\/jats:title>\n            <jats:p>On admission, we started thiamazole therapy for Basedow disease, and her thyroid hormone levels normalized.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Outcomes:<\/jats:title>\n            <jats:p>Abdominal CT revealed disappearance of edematous wall thickening of the gallbladder, which was likely associated with an improvement in thyroid function. The patient was discharged 10\u200adays after admission.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Lessons:<\/jats:title>\n            <jats:p>We encountered a case of hyperthyroidism and Basedow disease accompanied by edematous wall thickening of the gallbladder and various fluid retentions as the first symptoms. Such edematous wall thickening of the gallbladder and various fluid retentions were reduced, together with the improvement of hyperthyroidism.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000028720","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T14:00:28Z","timestamp":1643378428000},"page":"e28720","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Edematous wall thickening of the gallbladder induced by hyperthyroidism"],"prefix":"10.1097","volume":"101","author":[{"given":"Katsumasa","family":"Koyama","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine 1, Kawasaki Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatoshi","family":"Anno","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 1, Kawasaki Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 1, Kawasaki Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 2, Kawasaki Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 2, Kawasaki Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Kaneto","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Tomoda","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 1, Kawasaki Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"R1-20250504","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S0140-6736(86)91067-6","article-title":"Fluid retention and early thyroid failure","volume":"1","author":"Wheatley","year":"1986","journal-title":"Lancet"},{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1161\/CIRCULATIONAHA.106.678326","article-title":"Thyroid disease and the heart","volume":"116","author":"Klein","year":"2007","journal-title":"Circulation"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ejim.2005.11.023","article-title":"Pulmonary hypertension is frequent in hyperthyroidism and normalizes after therapy","volume":"17","author":"Marvisi","year":"2006","journal-title":"Eur J Intern Med"},{"key":"R4-20250504","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2214\/AJR.05.1712","article-title":"Diffuse gallbladder wall thickening: differential diagnosis","volume":"188","author":"van Breda Vriesman","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"R5-20250504","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s40064-015-1100-x","article-title":"Computed tomography findings in acute decompensated heart failure: periportal collar sign and lymphedema in the hepatoduodenal ligament and retroperitoneal space","volume":"4","author":"Takeda","year":"2015","journal-title":"Springerplus"},{"key":"R6-20250504","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/s00380-014-0518-3","article-title":"Autoimmunity and pulmonary hypertension in patients with Graves disease","volume":"30","author":"Sugiura","year":"2015","journal-title":"Heart Vessels"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000028720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T04:26:49Z","timestamp":1746332809000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000028720"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2022,1,28]]},"references-count":6,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000028720","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,28]]},"assertion":[{"value":"2021-11-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}