{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:23:46Z","timestamp":1785569026398,"version":"3.56.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"25","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>We aim to assess factors that affect overall survival in patients with primary small intestinal gastrointestinal stromal tumors (GISTs) who had undergone R0 resection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method:<\/jats:title>\n            <jats:p>A retrospective analysis reviewed the data of 82 consecutive confirmed GIST patients at a single medical center in China from January 2012 to June 2020. The survival curve was estimated using the Kaplan\u2013Meier method, and independent prognostic factors were confirmed using the Cox regression model.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A total of 82 patients were included in the study: 42 men and 40 women, the mean age was 59 years old (23\u201383 years old). Tumors were commonly found in the jejunum (46.3%), ileum (20.7%), and duodenum (32.9%). The median tumor size was 6.0\u200acm (range: 1.0\u201315.0\u200acm). The number of mitoses per one 50 high-power field was used to define the mitotic rates. In our present study, 56 patients presented a mitotic rate \u22645 (68.3%) and 26 patients showed a rate &gt;5 (31.7%) at the time of diagnosis. All patients accepted tumor resection without lymph node resection. The positivity rate was 97.6% for CD117, 96.3% for delay of germination 1, 65.9% for CD34, 6.1% for S-100, and 59.8% for smooth muscle actin using immunohistochemistry. Tumor size, tumor rupture, Ki67 index, mitotic index, and postoperative imatinib were independent prognostic factors for small intestinal GISTs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In this study, larger tumor size, high Ki67 index, high mitotic index, the occurrence of tumor rupture, and use of imatinib were independent unfavorable prognostic indicators.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000029487","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T12:07:40Z","timestamp":1656331660000},"page":"e29487","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["The analysis of prognostic factors of primary small intestinal gastrointestinal stromal tumors with R0 resection"],"prefix":"10.1097","volume":"101","author":[{"given":"Hui","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Hernia and Colorectal Surgery, The Second Hospital of Dalian Medical University, Dalian, People's Republic of China"},{"name":"Dalian Medical University, Dalian, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhaoHui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hernia and Colorectal Surgery, The Second Hospital of Dalian Medical University, Dalian, People's Republic of China"},{"name":"Dalian Medical University, Dalian, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanYing","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Hernia and Colorectal Surgery, The Second Hospital of Dalian Medical University, Dalian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZeZhong","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Hernia and Colorectal Surgery, The Second Hospital of Dalian Medical University, Dalian, People's Republic of China"},{"name":"Dalian Medical University, Dalian, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ri Hyok","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Hernia and Colorectal Surgery, The Second Hospital of Dalian Medical University, Dalian, People's Republic of China"},{"name":"Dalian Medical University, Dalian, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hernia and Colorectal Surgery, The Second Hospital of Dalian Medical University, Dalian, People's Republic of 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