{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:06:55Z","timestamp":1792080415472,"version":"4.4.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"25","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>The Hammersmith infant neurological examination (HINE) is a highly predictive tool for the easy and low-cost detection of cerebral palsy. Between 2015 and 2016, the rapid spread of the Zika virus (ZIKV) in Brazil was responsible for an increase in microcephaly cases. This study aimed to verify the accuracy of the HINE for the early detection of neurological problems in Brazilian babies exposed to ZIKV.<\/jats:p>\n            <jats:p>This was a cross sectional case-control study of children exposed to ZIKV. This study was part of the Jundia\u00ed ZIKV Cohort. Of a total sample of 782 children, 98 were evaluated (26 in the exposed group and 63 in the control group). We included late preterm infants and term infants who were exposed to the ZIKV and were participants in the ZIKV Cohort study. Student's <jats:italic toggle=\"yes\">t<\/jats:italic>-test and stepwise multivariate logistic regression were used to compare groups.<\/jats:p>\n            <jats:p>Of the 26 items evaluated in the five scored categories of the HINE (cranial nerve function, posture, movements, tone, reflexes, and reactions), only the difference in ankle dorsiflexion between the exposed and the control groups was statistically significant. However, some items showed a significant trend in relation to the control group.<\/jats:p>\n            <jats:p>Our results demonstrated the importance of early neurological assessment of infants exposed to ZIKV, even in those without a microcephaly diagnosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000029488","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T12:04:54Z","timestamp":1656331494000},"page":"e29488","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Accuracy of the Hammersmith infant neurological examination for the early detection of neurological changes in infants exposed to Zika virus"],"prefix":"10.1097","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9957-1222","authenticated-orcid":false,"given":"Tathiana Ghisi","family":"de Souza","sequence":"first","affiliation":[{"name":"Faculdade de Medicina de Jundia\u00ed, Departamento de Pediatria, Jundia\u00ed, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bagne","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Jundia\u00ed, Departamento de Pediatria, Jundia\u00ed, SP, Brazil"},{"name":"Universidade Paulista, UNIP, Jundia\u00ed, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Mizani","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Jundia\u00ed, Departamento de Pediatria, Jundia\u00ed, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Abdalla","family":"Rotob","sequence":"additional","affiliation":[{"name":"Universidade Paulista, UNIP, Jundia\u00ed, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Estela","family":"Gazeta","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Jundia\u00ed, Departamento de Pediatria, Jundia\u00ed, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Laura","family":"de Sene Am\u00e2ncio Zara","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Departamento de Sa\u00fade Coletiva, Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Goi\u00e2nia, GO, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cohorte Zika virus","family":"Jundia\u00ed","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Jundia\u00ed, Departamento de Pediatria, Jundia\u00ed, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo Duarte","family":"Passos","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Jundia\u00ed, Departamento de Pediatria, Jundia\u00ed, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"R1-20250504","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3390\/v13040687","article-title":"Zika Brazilian Cohorts (ZBC) consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy","volume":"13","author":"Alecrim","year":"2021","journal-title":"Viruses"},{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jamapediatrics.2016.3982","article-title":"Characterizing the pattern of anomalies in congenital Zika syndrome for pediatric clinicians","volume":"171","author":"Moore","year":"2017","journal-title":"JAMA Pediatr"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2105\/AJPH.2016.303113","article-title":"The epidemic of Zika virus-related microcephaly in Brazil: detection, control, 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