{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:48:41Z","timestamp":1788648521291,"version":"build-2803163510"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"25","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"crossref","award":["2020SK50516"],"award-info":[{"award-number":["2020SK50516"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>This study aims to compare the differences between obstructed and unobstructed total anomalous pulmonary venous connection (TAPVC) using echocardiography, and to evaluate the clinical and echocardiographic parameters associated with pulmonary venous obstruction (PVO).<\/jats:p>\n            <jats:p>We conducted a retrospective study of 70 patients with TAPVC between 2014 and 2019. The morphologic and hemodynamic echocardiographic parameters of patients were observed and measured, and the parameters between obstructed and unobstructed TAPVC were compared. The clinical and echocardiographic parameter differences between the two groups were used for ROC curve analysis.<\/jats:p>\n            <jats:p>Obstructed TAPVC was found in 30 (42.9%) of 70 patients. Between obstructed and unobstructed TAPVC, there were significant differences in atrial septal defect size, pulmonary artery maximum velocity (PA V<jats:sub>max<\/jats:sub> ), peak E velocity of mitral valve, left ventricular fractional shortening, left ventricular ejection fraction, stroke volume and the incidence of patent ductus arteriosus, but there was no significant difference in birth weight. The first diagnosis age of obstructed TAPVC was earlier than unobstructed type. The ROC curve analysis for the first diagnosis age showed the sensitivity and specificity were 76.7%, 80% respectively. The ROC curve analysis for the PA V<jats:sub>max<\/jats:sub> showed the sensitivity and specificity were 88.5%, 67.6% respectively.<\/jats:p>\n            <jats:p>Patients with TAPVC had a high incidence of PVO. The presence of PVO can affect the size of atrial septal defect and the closure of the ductus arteriosus, cause significant changes in PA V<jats:sub>max<\/jats:sub>, peak E velocity of mitral valve, left ventricular fractional shortening, left ventricular ejection fraction, stroke volume, lead to earlier symptoms and earlier first diagnosis age. The first diagnosis age and PA V<jats:sub>max<\/jats:sub> were excellent values since they associated with PVO.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000029552","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T12:08:50Z","timestamp":1656331730000},"page":"e29552","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Echocardiographic evaluation of total anomalous pulmonary venous connection"],"prefix":"10.1097","volume":"101","author":[{"given":"Yonghua","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Radiology, Hunan Children's Hospital, University of South China, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Hunan Children's Hospital, University of South China, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qiu","sequence":"additional","affiliation":[{"name":"House of Journal of pediatric surgery, Hunan Children's Hospital, University of South China, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hunan Children's Hospital, University of South China, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9342-670X","authenticated-orcid":false,"given":"Ke","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hunan Children's Hospital, University of South China, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"R1-20250504","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1016\/S0003-4975(99)01237-0","article-title":"Congenital heart surgery nomenclature and database project: pulmonary venous anomalies","volume":"69","author":"Herlong","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2459\/JCM.0b013e328329155f","article-title":"Late complication of total anomalous pulmonary venous drainage in an adult: \u2018a diagnostic challenge\u2019","volume":"11","author":"Rafiq","year":"2010","journal-title":"J Cardiovas Med"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1161\/CIRCULATIONAHA.106.635441","article-title":"Factors associated with mortality and reoperation in 377 children with total anomalous pulmonary venous 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type"],"short-title":[],"issued":{"date-parts":[[2022,6,24]]},"references-count":19,"journal-issue":{"issue":"25","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000029552","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,24]]},"assertion":[{"value":"2020-10-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}