{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T09:06:06Z","timestamp":1794301566509,"version":"4.9.0"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"30","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute kidney injury (AKI) that develops during pregnancy results from pregnancy-induced hypertension, hemorrhage, and sepsis, associated with morbidity and mortality in the fetus and mother. This meta-analysis was conducted to evaluate the incidence of pregnancy-related AKI (PR-AKI) and adverse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PubMed and Scopus were systematically searched for studies published between 1980 and 2021. We included cross-sectional, retrospective, and prospective cohort studies that reported the incidence of PR-AKI as well as adverse fetal and maternal clinical outcomes. A random-effects model meta-analysis was performed to generate summary estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The meta-analysis included 31 studies (57,529,841 participants). The pooled incidence of PR-AKI was 2.0% (95% confidence interval [CI] 1.0\u20133.7). Only 49.3% of patients received antenatal care. The most common cause of PR-AKI was preeclampsia (36.6%, 95% CI 29.1\u201344.7). The proportion of patients requiring hemodialysis was 37.2% (95% CI 26.0\u201349.9). More than 70% of patients had complete recovery of renal function, while 8.5% (95% CI 4.7\u201314.8) remained dependent on dialysis. The pooled mortality rate of PR-AKI was 12.7% (95% CI 9.0\u201317.7). In addition, fetal outcomes were favorable, with an alive birth rate of 70.0% (95% CI 61.2\u201377.4). However, the rate of abortion and\/or stillbirth was approximately 25.4% (95% CI 18.1\u201334.4), and the rate of intrauterine death was 18.6% (95% CI 12.8\u201326.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although the incidence of PR-AKI is not high, this condition has a high impact on morbidity and mortality in both fetal and maternal outcomes. Early prevention and treatment from health care professionals are needed in PR-AKI, especially in the form of antenatal care and preeclampsia medication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/md.0000000000029563","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T18:03:03Z","timestamp":1660154583000},"page":"e29563","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":43,"title":["Incidence of acute kidney injury during pregnancy and its prognostic value for adverse clinical outcomes: A systematic review and meta-analysis"],"prefix":"10.1097","volume":"101","author":[{"given":"Thananda","family":"Trakarnvanich","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanun","family":"Ngamvichchukorn","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9813-9219","authenticated-orcid":false,"given":"Paweena","family":"Susantitaphong","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"},{"name":"Research Unit for Metabolic Bone Disease in CKD patients, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00404-008-0682-8","article-title":"Acute kidney injury requiring dialysis in obstetric patients: a series of 55 cases in Brazil.","volume":"279","author":"Silva","year":"2009","journal-title":"Arch Gynecol Obstet"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4103\/0971-4065.45291","article-title":"Pregnancy related acute kidney injury: a single center experience from the Kashmir Valley.","volume":"18","author":"Najar","year":"2008","journal-title":"Indian J Nephrol"},{"key":"R4-20250504","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1681\/ASN.2014100954","article-title":"Characteristics and outcome of AKI treated with dialysis during pregnancy and the postpartum 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