{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:05:16Z","timestamp":1747181116561,"version":"3.40.5"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"52","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,30]]},"abstract":"<jats:p>This study aims to assess the prevalence, clinical, and ultrasonography (US) in thyroid screening in healthy subjects with general symptoms of thyroid abnormality in low iodine intake in Bajulmati primary care center, East Java Indonesia. We retrospectively reviewed US thyroid examination of 74 subjects with symptoms of mass in the neck, shaky, sleep difficulties, over sweating, and chronic fatigue on September 15<jats:sup>th<\/jats:sup>, 2021. Following the WHO guidelines, subjects also underwent physical examination in which the result were classified into 3 categories, that is, no palpable nor visible goiter, palpable but no visible goiter, as well as palpable and visible goiter. We evaluate US thyroid characteristics following Korean Society of Thyroid Radiology guidelines. Image analysis was reviewed by 4 general radiologists with 2 to 13 years\u2019 experience. Categorical variables were compared using chi-squared or Fisher exact tests. Correlation between variables was measured with gamma statistics. Statistical analyses were conducted using IBM SPSS Statistics 23.0. A <jats:italic toggle=\"yes\">P<\/jats:italic>-value\u2005&lt;\u2005.05 was considered to indicate statistical significance. Of the 74 subjects, 32 (43.2%) show abnormalities. Statistical analysis showed no significant differences in the result of thyroid US in subjects with complaint fatigue (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.464), insomnia (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.777), over sweating (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.158), and tremor (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.778), but there were significant differences with the complaint of mass in the neck (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.008). Furthermore, there was also a strong correlation between goiter palpation and US thyroid result (<jats:italic toggle=\"yes\">R<\/jats:italic>\u2005=\u20050.773, <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.00). We conclude there were significant differences in US result of patients with and without complaint of mass in the neck. We also found a strong correlation between goiter palpation and US examination. Clinical findings, laboratory examination, cytology and molecular markers, patients\u2019 age, nodules size, and ultrasound features should be considered for the treatment planning.<\/jats:p>","DOI":"10.1097\/md.0000000000032546","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T13:03:54Z","timestamp":1672405434000},"page":"e32546","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and ultrasonography evaluation of thyroid tumor screening in symptomatic patient of Bajulmati primary care center, Banyuwangi, East Java, Indonesia"],"prefix":"10.1097","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8442-7287","authenticated-orcid":false,"given":"Rosy","family":"Setiawati","sequence":"first","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tri","family":"Wulanhandarini","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fierly","family":"Hayati","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dyah","family":"Erawati","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-3667","authenticated-orcid":false,"given":"Merlin Guntur","family":"Jaya","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andi Ahmad","family":"Thoriq","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Triana Mediyawati","family":"Wijaya","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galih Nur","family":"Ismiyati","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dyan Wahyu","family":"Kusumaningrum","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Koesmarsono","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes Triana","family":"Basja","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Ikhsan","family":"Nugroho","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvi","family":"Yuliana","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syadza Zahrah","family":"Shedyta","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendra Boy","family":"Situmorang","sequence":"additional","affiliation":[{"name":"Radiology Department, Universitas Airlangga, Faculty of Medicine, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20250504","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S2213-8587(22)00035-3","article-title":"The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020.","volume":"10","author":"Pizzato","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CCO.0000000000000148","article-title":"The changing epidemiology of thyroid cancer: why is incidence increasing?.","volume":"27","author":"Vigneri","year":"2015","journal-title":"Curr Opin Oncol"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"T235","DOI":"10.1530\/ERC-14-0131","article-title":"The influence of the environment on the development of thyroid tumors: a new appraisal.","volume":"21","author":"Marcello","year":"2014","journal-title":"Endocr Relat Cancer"},{"key":"R4-20250504","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/01.ruq.0000226877.19937.a1","article-title":"Management of thyroid nodules detected at US: society of radiologists in ultrasound consensus conference statement.","volume":"22","author":"Frates","year":"2006","journal-title":"Ultrasound Q"},{"key":"R5-20250504","first-page":"96","article-title":"Thyroid palpation versus high-resolution thyroid ultrasonography in the detection of nodules.","volume":"487","author":"Wiest","year":"1998","journal-title":"J Ultrasound Med"},{"key":"R6-20250504","first-page":"1","article-title":"Thyroid nodules: diagnostic evaluation based on thyroid cancer risk assessment.","volume":"368","author":"Singh Ospina","year":"2020","journal-title":"BMJ"},{"key":"R7-20250504","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1089\/105072504322783812","article-title":"Prevalence, clinical and ultrasonographic characteristics of thyroid incidentalomas.","volume":"14","author":"Kang","year":"2004","journal-title":"Thyroid"},{"key":"R9-20250504","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.beem.2014.01.001","article-title":"Epidemiology of nodular goitre. 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