{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T12:40:11Z","timestamp":1744807211213,"version":"3.40.4"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4,4]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>MicroRNA-451a (miR-451a) is associated with the treatment response and outcomes in patients with Hodgkin lymphoma. The present study aimed to investigate the expression of miR-451a in patients with Hodgkin\u2019s lymphoma, and to analyze its association with survival and prognosis in clinical patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A total of 164 patients with Hodgkin\u2019s lymphoma and 164 healthy controls (control group) were enrolled in this study. Blood samples were collected from participants and expression levels of miR-451a were detected using reverse transcription quantitative polymerase chain reaction. Multivariate Cox-regression analysis was used to analyze the association between serum level of miR-451a and overall survival, as well as prognosis of Hodgkin\u2019s lymphoma patients. Kaplan\u2013Meier curve was used to analyze the five-year recurrence.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Outcomes demonstrated that Hodgkin\u2019s lymphoma patients had lower miR-451a serum level than healthy controls. The present results showed that expression of miR-451a was higher in the group where chemotherapy was effective than that patient where chemotherapy was ineffective. High serum levels of miR-451a were associated with longer overall survival and better prognosis of Hodgkin\u2019s lymphoma patients than patients who had lower serum miR-451a levels. Multivariate Cox-regression analysis identified miR-451a serum level was positively correlated with overall survival and prognosis in patients with Hodgkin\u2019s lymphoma.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>The results of the present study demonstrate that serum levels of miR-451a is decreased in patients with Hodgkin\u2019s lymphoma. Data indicate that serum levels of miR-451a can be used as one of the potential biomarkers and prognosis for patients with Hodgkin\u2019s lymphoma.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000032587","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T12:01:01Z","timestamp":1744804861000},"page":"e32587","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Association between microRNA-451a expression in serum and survival and prognosis in patients with Hodgkin\u2019s lymphoma"],"prefix":"10.1097","volume":"104","author":[{"given":"Fuying","family":"Huo","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, The Affiliated Second Hospital of Mudanjiang Medical University, Mudanjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of 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