{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T16:07:48Z","timestamp":1773590868807,"version":"3.50.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"52","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,30]]},"abstract":"<jats:p>Lower extremity revascularization (LER) for peripheral artery disease in elderly patients is associated with a high risk of perioperative morbidity and mortality. This study aimed to a conduct retrospective review and propensity score matching analysis to determine whether the use of regional anesthesia (RA) instead of general anesthesia (GA) in geriatric patients undergoing LER for peripheral artery disease results in improved short-term mortality and health outcomes. We reviewed medical records of 1271 patients aged\u2005&gt;65 years who underwent LER at our center between May 1998 and February 2016. According to the anesthesia method, patients were grouped in the GA and RA groups. The primary outcome was short-term mortality (7-day and 30-day). The secondary outcomes were 5-year survival rate, intraoperative events, postoperative morbidity, and postoperative length of stay. A propensity score-matched cohort design was used to control for potentially confounding factors including patient demographics, comorbidities, American Society of Anesthesiologists physical status, and preoperative medications. After propensity score matching, 722 patients that received LER under GA (n\u2005=\u2005269) or RA (n\u2005=\u2005453) were identified. Patients from the GA group showed significantly higher 7-day mortality than those from the RA group (5.6% vs 2.7% <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.048); however, there was no significant difference in 30-day mortality between the groups (GA vs RA: 6.3% vs 3.6%, <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.083). The 5-year survival rate and incidence of arterial and central venous catheter placement or intraoperative dopamine and epinephrine use were significantly higher in the GA group than in the RA group (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005&lt;\u2005.05). In addition, the frequency of immediate postoperative oxygen therapy or mechanical ventilation support was higher in the GA group (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005&lt;\u2005.05). However, there was no difference in the postoperative cardiopulmonary and cerebral complications between the 2 groups. These results suggest that RA can reduce intraoperative hemodynamic support and provide immediate postoperative respiratory intensive care. In addition, the use of RA may be associated with better short-term and 5-year survival rates in geriatric patients undergoing LER.<\/jats:p>","DOI":"10.1097\/md.0000000000032597","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T13:03:24Z","timestamp":1672405404000},"page":"e32597","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Impact of regional anesthesia on outcomes of geriatric patients undergoing lower extremity revascularization: A propensity score-matched cohort study"],"prefix":"10.1097","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-5483","authenticated-orcid":false,"given":"Jung A","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohan","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Joo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Gyu","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeha","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Department of Surgery, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Hyuk","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Department of Surgery, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woon Seok","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20250504","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1097\/SMJ.0b013e3181bb9ab8","article-title":"Peripheral arterial disease: current perspectives and new trends in management.","volume":"102","author":"Aslam","year":"2009","journal-title":"South Med J"},{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1016\/j.jacc.2016.11.007","article-title":"2016 AHA\/ACC guideline on the management of patients with lower extremity peripheral artery disease: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines.","volume":"69","author":"Gerhard-Herman","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.anclin.2014.05.004","article-title":"Perioperative management of lower extremity 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