{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:21:53Z","timestamp":1789129313647,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>To observe the effect of low-dose propofol combined with dexamethasone on the prevention of postoperative nausea and vomiting (PONV) in gynaecological day surgery under remimazolam-based general anesthesia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A total of 120 patients, aged from 18 to 65 years old, American Society of Anesthesiologists grade I or II, were scheduled to undergo hysteroscopy under total intravenous anesthesia. The patients were divided into 3 groups (n = 40 each): dexamethasone plus saline group (DC group), dexamethasone plus droperidol group (DD group) and dexamethasone plus propofol group (DP group). Dexamethasone 5\u2009mg and flurbiprofen axetil 50\u2009mg were given intravenously before induction of general anesthesia. Anesthesia induction: remimazolam 6\u2009mg\/kg\/hours was continuously pumped until sleep and slow intravenous injection of alfentanil 20 ug\/kg and mivacurium chloride 0.2\u2009mg\/kg was given. Anesthesia maintenance: remimazolam 1\u2009mg\/kg\/hour and alfentanil 40 ug\/kg\/hours were continuously pumped. After the start of surgery, DC group was given 2\u2009mL saline, DD group was given droperidol 1\u2009mg, and DP group was given propofol 20\u2009mg. Primary outcome: incidence of PONV in the postanesthesia care unit (PACU). Secondary outcome: incidence of PONV in patients within 24 hours after surgery, as well as general patient data, duration of anesthesia, the recovery time of patients, dose of remimazolam and alfentanil, etc.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>In PACU, patients of group DD and DP showed less PONV than those in group DC (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .05). Within 24 hours after operation, there was no significant difference in the incidence of PONV among the 3 groups (<jats:italic toggle=\"yes\">P<\/jats:italic> &gt; .05), but the incidence of vomiting in DD group and DP group was significantly lower than that in DC group (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .05). There was no significant difference in general data, anesthesia time, the recovery time of patients and dosage of remimazolam and alfentanil among the 3 groups (<jats:italic toggle=\"yes\">P<\/jats:italic> &gt; .05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>The effect of low-dose propofol combined with dexamethasone to prevent PONV under remimazolam-based general anesthesia was similar to that of droperidol combined with dexamethasone, both of which significantly reduced the incidence of PONV in the PACU compared to dexamethasone alone. However, low-dose propofol combined with dexamethasone had little effect on the incidence of PONV within 24 hours compared to dexamethasone alone and only reduced the incidence of postoperative vomiting in patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000033249","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T17:07:07Z","timestamp":1678468027000},"page":"e33249","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Effect of low-dose propofol combined with dexamethasone on the prevention of postoperative nausea and vomiting in gynaecological day surgery under remimazolam-based general anesthesia"],"prefix":"10.1097","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-8731","authenticated-orcid":false,"given":"Hongyi","family":"Xiao","sequence":"first","affiliation":[{"name":"School of Anesthesiology, Weifang Medical University, Weifang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Weifang People\u2019s Hospital, Weifang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Man","sequence":"additional","affiliation":[{"name":"School of Anesthesiology, Weifang Medical University, Weifang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Anesthesiology, Weifang Medical University, Weifang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4254-1473","authenticated-orcid":false,"given":"Fanceng","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Weifang People\u2019s Hospital, Weifang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250504","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1213\/ANE.0000000000004833","article-title":"Fourth consensus guidelines for the management of postoperative nausea and vomiting [published correction appears in Anesth Analg. 2020 Nov;131(5):e241].","volume":"131","author":"Gan","year":"2020","journal-title":"Anesth Analg"},{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cps.2013.04.007","article-title":"Management of postoperative nausea and vomiting in ambulatory surgery: the big little problem.","volume":"40","author":"Keyes","year":"2013","journal-title":"Clin Plast Surg"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12871-021-01373-y","article-title":"Efficacy and safety of remimazolam besylate versus propofol during hysteroscopy: single-centre randomized controlled trial [published correction appears in BMC Anesthesiol. 2021 Jun 18;21(1):173].","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Anesthesiol"},{"key":"R4-20250504","article-title":"A comparison of remimazolam and propofol for postoperative nausea and vomiting: a propensity score-matched, observational, single-center cohort study [published online ahead of print, 2022 Oct 17].","author":"Suzuki","year":"2022","journal-title":"Korean J Anesthesiol"},{"key":"R5-20250504","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00540-020-02788-6","article-title":"Efficacy and safety of remimazolam versus propofol for general anesthesia: a multicenter, single-blind, randomized, parallel-group, phase IIb\/III trial.","volume":"34","author":"Doi","year":"2020","journal-title":"J Anesth"},{"key":"R6-20250504","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00101-002-0325-6","article-title":"Pharmako\u00f6konomische modelle zur kostenberechnung dargestellt am beispiel einer studie zur prophylaxe von ubelkeit und erbrechen in der postoperativen phase kosten-wirksamkeits-analyse einer tropisetron-supplementierten desfluran-an\u00e4sthesie im vergleich zu einer propofol-TIVA [pharmacoeconomical model for cost calculation using a study on prophylaxis of nausea and vomiting in the postoperative phase as an example. 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