{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:16:26Z","timestamp":1782922586242,"version":"3.54.5"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,16]]},"abstract":"<jats:p>The prevalence of ankylosing spondylitis (AS) and major depressive disorders (MDD) becomes increasingly pronounced, exerting a significant impact on the life quality of contemporary people. Although there is mounting evidence of a link between AS and major depression disorders, the specific interactions between the two have not been thoroughly investigated. To this end, this study aimed to check whether the gene expression profiles of patients with AS and major depression disorders overlapped, and whether there were any functional links between the identified genes via protein\u2013protein interactions. Herein, the relationship between the 4 datasets (GSE73754, GSE98793, GSE25101, and GSE54564) chosen from the Gene Expression Omnibus for evaluation and validation was investigated using gene characterization and functional enrichment. Then, following Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes that explore the biological processes of common genes and demonstrate the interrelationships between common genes, hub genes were obtained using the STRING database and the application cytoHubba plugin of Cytoscape software. The correlation between the gene and 22 types of immuno-infiltrating cells was explored, and the key gene as well as the diagnostic efficiency of the key gene was obtained through verification. A total of 204 shared genes were discovered, the majority of which were functionally enriched in Ribosome, Coronavirus disease COVID19, Starch and sucrose metabolism, and Galactose metabolism. Then, efforts were made to go through STRING. Immuno-infiltration studies revealed that Neutrophils, T cells CD8, T cells CD4 naive, T cells CD4 memory resting, T cells CD4 memory activated, and T cells regulatory were associated with the pathogenesis of AS and MDD. Additionally, the receiver operating characteristic curve revealed that the key gene MRPL13 played diagnostic roles in AS and MDD after intersecting 10 hub genes with 37 differential expression genes from the 2 validation datasets. The obtained results suggest an overlapping genetic structure between AS and major depression disorders. MRPL13 may provide key insights into the relationship between AS and MDD.<\/jats:p>","DOI":"10.1097\/md.0000000000033985","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T18:07:16Z","timestamp":1686938836000},"page":"e33985","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Genetic association between ankylosing spondylitis and major depressive disorders: Shared pathways, protein networks and the key gene"],"prefix":"10.1097","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8709-2184","authenticated-orcid":false,"given":"Tiantian","family":"Dong","sequence":"first","affiliation":[{"name":"Center for External Treatment of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, People\u2019s Republic of China"},{"name":"College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyou","family":"Lu","sequence":"additional","affiliation":[{"name":"Center for External Treatment of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, People\u2019s Republic of China"},{"name":"College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiguo","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxiang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250504","doi-asserted-by":"crossref","first-page":"e067606","DOI":"10.1136\/bmj-2021-067606","article-title":"Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US food and drug administration: individual participant data analysis.","volume":"378","author":"Stone Marc","year":"2022","journal-title":"BMJ"},{"key":"R2-20250504","doi-asserted-by":"crossref","first-page":"1759720X20970028","DOI":"10.1177\/1759720X20970028","article-title":"Depression in patients with spondyloarthritis: prevalence, incidence, risk factors, mechanisms and management.","volume":"12","author":"Parkinson","year":"2020","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0140-6736(22)01212-0","article-title":"Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial.","volume":"400","author":"Deodhar","year":"2022","journal-title":"Lancet"},{"key":"R4-20250504","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jaut.2014.01.015","article-title":"The classification and diagnostic criteria of ankylosing spondylitis.","volume":"48\u201349","author":"Raychaudhuri","year":"2014","journal-title":"J Autoimmun"},{"key":"R5-20250504","doi-asserted-by":"crossref","first-page":"UT17042BR1C","DOI":"10.4088\/JCP.UT17042BR1C","article-title":"Major depressive disorder in primary care: strategies for identification.","volume":"81","author":"Trivedi","year":"2020","journal-title":"J Clin Psychiatry"},{"key":"R6-20250504","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.gheart.2016.10.024","article-title":"The Global Burden of Disease Study and the Preventable Burden of NCD.","volume":"11","author":"Benziger","year":"2016","journal-title":"Glob Heart"},{"key":"R7-20250504","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.2174\/1568026618666180516100805","article-title":"Associations between depressive disorders and inflammatory rheumatic diseases.","volume":"18","author":"Varan","year":"2018","journal-title":"Curr Top Med Chem"},{"key":"R8-20250504","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10067-017-3907-z","article-title":"Prevalence of psychological disorders, sleep disturbance and stressful life events and their relationships with disease parameters in Chinese patients with ankylosing spondylitis.","volume":"37","author":"Jiang","year":"2018","journal-title":"Clin Rheumatol"},{"key":"R9-20250504","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/RHU.0b013e31823a498e","article-title":"Psychological status in Moroccan patients with ankylosing spondylitis and its relationships with disease parameters and quality of life.","volume":"17","author":"Hakkou","year":"2011","journal-title":"J Clin Rheumatol"},{"key":"R10-20250504","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00296-010-1616-x","article-title":"Infliximab, a TNF-\u03b1 antagonist treatment in patients with ankylosing spondylitis: the impact on depression, anxiety and quality of life level.","volume":"32","author":"Ertenli","year":"2012","journal-title":"Rheumatol Int"},{"key":"R11-20250504","doi-asserted-by":"crossref","first-page":"565","DOI":"10.30773\/pi.2019.06.05","article-title":"Prevalence of depression in ankylosing spondylitis: a systematic review and meta-analysis.","volume":"16","author":"Zhang","year":"2019","journal-title":"Psychiatry Investig"},{"key":"R12-20250504","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s13075-019-1995-7","article-title":"Depression in ankylosing spondylitis and the role of disease-related and contextual factors: a cross-sectional study.","volume":"21","author":"Webers","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"R13-20250504","doi-asserted-by":"crossref","first-page":"110339","DOI":"10.1016\/j.pnpbp.2021.110339","article-title":"Genetic association between major depressive disorder and type 2 diabetes mellitus: shared pathways and protein networks.","volume":"111","author":"Liu","year":"2021","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"R14-20250504","doi-asserted-by":"crossref","first-page":"m4447","DOI":"10.1136\/bmj.m4447","article-title":"Axial spondyloarthritis: new advances in diagnosis and management.","volume":"372","author":"Ritchlin","year":"2021","journal-title":"BMJ"},{"key":"R15-20250504","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.18632\/aging.204030","article-title":"Effective biomarkers and therapeutic targets of nerve-immunity interaction in the treatment of depression: an integrated investigation of the miRNA-mRNA regulatory networks.","volume":"14","author":"Wu","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"R16-20250504","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nri797","article-title":"Gammadelta T cells: functional plasticity and heterogeneity.","volume":"2","author":"Carding","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"R17-20250504","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev-immunol-042617-053214","article-title":"Tissue-resident T cells and other resident leukocytes.","volume":"37","author":"Masopust","year":"2019","journal-title":"Annu Rev Immunol"},{"key":"R18-20250504","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41584-021-00625-y","article-title":"Ankylosing spondylitis: an autoimmune or autoinflammatory disease?","volume":"17","author":"Mauro","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"R19-20250504","doi-asserted-by":"crossref","first-page":"12255","DOI":"10.2147\/OTT.S263998","article-title":"MRPL13 is a prognostic cancer biomarker and correlates with immune infiltrates in breast cancer.","volume":"13","author":"Tao","year":"2020","journal-title":"Onco Targets Ther"},{"key":"R20-20250504","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1089\/dna.2020.5482","article-title":"Identification of candidate genes associated with breast cancer prognosis.","volume":"39","author":"Xu","year":"2020","journal-title":"DNA Cell Biol"},{"key":"R21-20250504","doi-asserted-by":"crossref","first-page":"7471291","DOI":"10.1155\/2021\/7471291","article-title":"Bioinformatics analysis of the molecular mechanism and potential treatment target of ankylosing spondylitis.","volume":"2021","author":"Meng","year":"2021","journal-title":"Comput Math Methods Med"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000033985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T01:09:57Z","timestamp":1746320997000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000033985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,16]]},"references-count":21,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000033985","relation":{},"ISSN":["0025-7974"],"issn-type":[{"value":"0025-7974","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6,16]]}}}