{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:06:28Z","timestamp":1747181188859,"version":"3.40.5"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"30","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,28]]},"abstract":"<jats:sec>\n            <jats:title>Rationale:<\/jats:title>\n            <jats:p>Thalassemia combined with extramedullary hematopoietic spinal cord compression is extremely rare; its ideal treatment is still controversial. Herein, we present 2 cases of thalassemia combined with extramedullary hematopoietic compression of the spinal cord wherein satisfactory results were obtained using unilateral bi-portal endoscopy (UBE).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patient concerns:<\/jats:title>\n            <jats:p>Case 1 was of a 43-year-old male who presented with a chief complaint of numbness of the left lower limb since 1-month. Case 2 involved a 23-year-old male who was admitted to the hospital with a chief complaint of numbness in both toes since 3 months and walking instability since 2 weeks. Both cases had a history of being diagnosed with thalassemia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Diagnoses:<\/jats:title>\n            <jats:p>Computed tomography and magnetic resonance imaging showed spinal canal space-occupying lesions causing dural compression and spinal stenosis. Postoperative pathology confirmed the spinal canal lesions to be extramedullary hematopoietic tissue.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interventions:<\/jats:title>\n            <jats:p>For spinal canal decompression, UBE supplemented by blood transfusion was performed for both cases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Outcomes:<\/jats:title>\n            <jats:p>All preoperative symptoms were relieved postoperatively; no recurrence was noted at the 6-month follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Lessons:<\/jats:title>\n            <jats:p>Thalassemia combined with extramedullary hematopoiesis can lead to acute spinal cord compression. UBE significantly relieves spinal stenosis symptoms; furthermore, UBE combined with blood transfusion for spinal canal extramedullary hematopoiesis gives satisfactory results, is safe, and has a low risk of spinal cord injury.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000034136","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T22:12:08Z","timestamp":1696630328000},"page":"e34136","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Unilateral bi-portal endoscopy for the treatment of thalassemia with extramedullary hematopoietic compression of the spinal cord: Two case reports"],"prefix":"10.1097","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-9444","authenticated-orcid":false,"given":"Jinhua","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, First Affiliated Hospital of Jinan University, Tianhe District, Guangzhou City, Guangdong Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, First Affiliated Hospital of Jinan University, Tianhe District, Guangzhou City, Guangdong Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, First Affiliated Hospital of Jinan University, Tianhe District, Guangzhou City, Guangdong Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, First Affiliated Hospital of Jinan University, Tianhe District, Guangzhou City, Guangdong Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20250504","first-page":"77","article-title":"Recent advance in gene therapy for thalassemia.","volume":"37","author":"Manbo","year":"2014","journal-title":"Int J Genet"},{"key":"R2-20250504","first-page":"237","article-title":"Spinal cord compression secondary to extramedullary hematopoiesis: a rareness in a young adult with thalassemia major.","volume":"88","author":"Fareed","year":"2017","journal-title":"Acta Biomed"},{"key":"R3-20250504","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1754-9485.2012.02397.x","article-title":"Extra-medullary haematopoiesis: a pictorial review of its typical and atypical locations.","volume":"56","author":"Sohawon","year":"2012","journal-title":"J Med Imaging Radiat Oncol"},{"key":"R4-20250504","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00586-010-1357-2","article-title":"Paraspinal extramedullary hematopoiesis in patients with thalassemia intermedia.","volume":"19","author":"Haidar","year":"2010","journal-title":"Eur Spine J"},{"key":"R5-20250504","first-page":"61","article-title":"[Compression of the spinal cord due to proliferation of bone marrow in epidural space in a splenectomized person with Cooley\u2019s disease].","volume":"38","author":"Gatto","year":"1954","journal-title":"Haematologica"},{"key":"R6-20250504","doi-asserted-by":"crossref","first-page":"e29334","DOI":"10.1097\/MD.0000000000029334","article-title":"Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patient: case report.","volume":"101","author":"Abbarh","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"R7-20250504","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/ccr3.3542","article-title":"Spinal cord compression due to extramedullary hematopoiesis in patient with Beta thalassemia major.","volume":"9","author":"Subahi","year":"2021","journal-title":"Clin Case Rep"},{"key":"R8-20250504","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.crad.2019.12.016","article-title":"Marrow outside marrow: imaging of extramedullary haematopoiesis.","volume":"75","author":"Malla","year":"2020","journal-title":"Clin Radiol"},{"key":"R9-20250504","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3171\/jns.1995.82.4.0657","article-title":"Nonsurgical approach to paraparesis due to extramedullary hematopoiesis. 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