{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:06:01Z","timestamp":1747181161583,"version":"3.40.5"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"51","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12,22]]},"abstract":"<jats:p>Sj\u00f6gren\u2019s syndrome is an autoimmune disease with the chronic inflammation of glandular tissues, typically salivary and lacrimal glands. Since mammary tissue shares the glandular structure, Sj\u00f6gren\u2019s syndrome may also target mammary tissue to cause breast diseases. We therefore determined whether primary Sj\u00f6gren\u2019s syndrome (pSS) is associated with the increased risk of breast cancer (BC) and breast fibrocystic change (FC). Total 282 female patients with pSS were recruited from a medical center in Taiwan, and patients\u2019 medical records were reviewed to identify BC and ultrasonographic breast FC. The prevalence, incidence and risk factors for BC and breast FC in pSS patients were determined, and the risk factors for these breast diseases were subsequently analyzed. Our results showed that pSS patients had the increased prevalence and incidence of BC, and high anti-SSA(Ro) antibody titers were found to be associated with the increased risk of BC. Breast FC was also found highly prevalent in these patients. Comorbidity analysis as risk factor for BC in pSS patients showed diabetes mellitus was strongly associated with the increased risk of BC (odds ratio\u2005=\u200510.4, <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.0006), whereas breast FC was inversely associated with the risk of BC (odds ratio\u2005=\u20050.077 <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.0158). These data indicated that pSS is association with the increased risk of BC and with the high prevalence of ultrasonographic breast FC. Our results also suggest that, in pSS patients, the high anti-SSA(Ro) antibody titers and diabetes mellitus confer the increased risk of BC, whereas the absence of ultrasonographic breast FC predicts the higher risk of BC.<\/jats:p>","DOI":"10.1097\/md.0000000000036769","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T19:02:39Z","timestamp":1703271759000},"page":"e36769","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Risk analysis of breast cancer and breast fibrocystic change in female primary Sj\u00f6gren\u2019s syndrome patients"],"prefix":"10.1097","volume":"102","author":[{"given":"Hsin-Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hsinchu Cathay General Hospital, Hsinchu, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui-Yuan","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Emergency, Cathay General Hospital, Taipei, Taiwan"},{"name":"School of Medicine, School of Medicine, National Tsing Hua University, Hsinchu, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-6634","authenticated-orcid":false,"given":"Shih-Chang","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, School of Medicine, National Tsing Hua University, Hsinchu, Taiwan"},{"name":"Division of Rheumatology and Immunology, Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan"},{"name":"School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20250503","first-page":"247","article-title":"The epidemiology of Sj\u00f6gren\u2019s syndrome.","volume":"6","author":"Patel","year":"2014","journal-title":"Clin Epidemiol"},{"key":"R2-20250503","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1177\/1759720X10381431","article-title":"Current aspects of pathogenesis in Sj\u00f6gren\u2019s syndrome.","volume":"2","author":"Voulgarelis","year":"2010","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"R3-20250503","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sj\u00f6gren\u2019s syndrome.","volume":"366","author":"Fox","year":"2005","journal-title":"Lancet"},{"key":"R4-20250503","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/acr.21610","article-title":"Primary Sj\u00f6gren\u2019s syndrome as a systemic disease: a study of participants enrolled in an international Sj\u00f6gren\u2019s syndrome registry.","volume":"64","author":"Malladi","year":"2012","journal-title":"Arthritis Care Res. 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