{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:38:09Z","timestamp":1794083889370,"version":"4.8.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,22]]},"abstract":"<jats:p>Sepsis remains a significant clinical challenge owing to its complex pathophysiology and variable prognosis. The early identification of patients at a higher risk of poor outcomes can be crucial for improving treatment strategies. This study aimed to evaluate the predictive value of early serum lactate and albumin levels and the lactate\/albumin (L\/A) ratio for 28-day prognosis in patients with sepsis. Patients diagnosed with sepsis between January 2021 and December 2022 were evaluated using a retrospective cohort methodology. Inclusion followed the International Consensus on sepsis and septic shock (Sepsis-3) guidelines and patients were selected based on well-defined criteria. Variables such as lactate, albumin, and the L\/A ratio were documented within the first 24 hours of admission. Statistical analyses were performed using various tools, including the nonparametric Mann\u2013Whitney <jats:italic toggle=\"yes\">U<\/jats:italic> test and receiver operating characteristic curves. A total of 301 patients were divided into the survival (n\u2005=\u2005167) and death (n\u2005=\u2005134) groups. Notable differences were detected in the incidence of pulmonary infection, shock, lactate, albumin, and the L\/A ratio. The L\/A ratio was identified as a key predictor with an area under the curve of 0.868, an optimal cutoff value of &gt;0.17, a sensitivity of 56.21%, and a specificity of 94.18%. Significant disparities in mortality rates and survival times were observed for the lactate, albumin, and L\/A levels. This study underscores the predictive value of early serum lactate and albumin levels and the L\/A ratio for 28-day prognosis in patients with sepsis, with the L\/A ratio showing a superior predictive capability. These findings highlight the importance of L\/A ratio as a robust and precise marker for evaluating the future clinical course of patients with sepsis, potentially aiding early detection and management.<\/jats:p>","DOI":"10.1097\/md.0000000000037535","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T18:02:53Z","timestamp":1711994573000},"page":"e37535","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Evaluating the predictive value of initial lactate\/albumin ratios in determining prognosis of sepsis patients"],"prefix":"10.1097","volume":"103","author":[{"given":"Jianhua","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, Zhejiang Province, 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