{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:42:44Z","timestamp":1765233764388,"version":"3.40.5"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,29]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Extramammary Paget disease is a relatively rare and less malignant intraepithelial adenocarcinoma. t is found in areas with abundant distribution of apocrine sweat glands such as the external genitalia, external genitalia, and perianal area, with fewer armpits. The disease progresses slowly and is prone to misdiagnosis in clinical practice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We retrospectively analyzed a female patient. She had a left axillary mass for more than 2 years. Recently, the mass increased and the surface skin was ulcerated. Then she went to Jiangxi Provincial Dermatology Hospital for left axillary lesion resection, and the postoperative pathology showed Paget disease outside the breast. For further diagnosis and treatment, she came to our hospital. We diagnosed a tumor with uncertain or unknown dynamics in the left axillary breast. Under general anesthesia, left subaxillary mass resection, freezing and left breast cancer breast conserving surgery was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The postoperative pathology of the left axillary mass combined with morphological and immunohistochemical results was consistent with Paget disease. Postoperative immunohistochemistry showed estrogen receptor (+, 20%), progesterone receptor (\u2212), human epidermal growth factor receptor-2 (3+), Ki-67 (30%), cytokine7 (+), and p63 (\u2212). Following up for 22 months, there has been no local recurrence, no swelling of the right axillary lymph node, no distant metastasis found on follow-up, and no complications such as upper limb lymphedema, upper limb sensory abnormalities, or motor disorders have been observed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Paget disease outside the axillary breast is relatively rare, and surgical resection is the best choice. The prognosis is good, and the recurrence rate is low.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000037541","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T18:02:27Z","timestamp":1711735347000},"page":"e37541","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Case report: A case of Paget disease outside the axillary breast"],"prefix":"10.1097","volume":"103","author":[{"given":"Zhibing","family":"Zhou","sequence":"first","affiliation":[{"name":"The Third Department of Mammary Gland, Third Hospital of Nanchang, Nanchang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4164-9873","authenticated-orcid":false,"given":"Bing","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Third Department of Mammary Gland, Third Hospital of Nanchang, Nanchang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Wu","sequence":"additional","affiliation":[{"name":"The Third Department of Mammary Gland, Third Hospital of Nanchang, Nanchang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wensong","family":"Wei","sequence":"additional","affiliation":[{"name":"The Third Department of Mammary Gland, Third Hospital of Nanchang, Nanchang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20250503","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.det.2010.08.002","article-title":"Extramammary Paget\u2019s disease: summary of current knowledge.","volume":"28","author":"Lam","year":"2010","journal-title":"Dermatol Clin"},{"key":"R2-20250503","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1365-4632.2010.04604.x","article-title":"Extramammary Paget\u2019s disease of the unilateral axilla: a review of seven cases in a 20-year experience.","volume":"50","author":"Chiu","year":"2011","journal-title":"Int J Dermatol"},{"key":"R3-20250503","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcma.2011.01.040","article-title":"Clinicopathologic characteristics of extramammary Paget\u2019s disease of the scrotum associated with sweat gland adenocarcinoma-a clinical retrospective study.","volume":"74","author":"Yan","year":"2011","journal-title":"J Chin Med Assoc"},{"key":"R5-20250503","first-page":"163","article-title":"Paget\u2019s disease outside the armpit and breast manifested as multifocal skin lesions.","volume":"48","author":"Ren","year":"2019","journal-title":"J Clin Dermatol"},{"key":"R6-20250503","first-page":"39","article-title":"A case of Paget\u2019s disease with sweat gland adenocarcinoma outside the armpit and breast.","volume":"49","author":"Li","year":"2020","journal-title":"J Clin Dermatol"},{"key":"R7-20250503","first-page":"553","article-title":"One case of primary extramammary Paget\u2019s disease in the armpit.","volume":"51","author":"Ye","year":"2022","journal-title":"J Clin Dermatol"},{"key":"R8-20250503","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5070\/D3221029792","article-title":"Multifocal extramammary Paget\u2019s disease -associated adenocarcinoma: a rare condition of flexoral skin of multiple sites.","volume":"22","author":"Wolf","year":"2016","journal-title":"Dermatol Online J"},{"key":"R9-20250503","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1346-8138.1996.tb04043.x","article-title":"Extramammary Paget\u2019s disease with distant skin metastasis.","volume":"23","author":"Kato","year":"1996","journal-title":"J Dermatol"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000037541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T23:02:11Z","timestamp":1746313331000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000037541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,29]]},"references-count":8,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000037541","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"type":"print","value":"0025-7974"},{"type":"electronic","value":"1536-5964"}],"subject":[],"published":{"date-parts":[[2024,3,29]]}}}