{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:35:49Z","timestamp":1790984149617,"version":"4.1.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,22]]},"abstract":"<jats:p>Pathergy test indicates nonspecific hyper-reactivity of the skin to aseptic trauma in Beh\u00e7et syndrome (BS) and is considered as an adjunctive diagnostic test with a good specificity albeit with low sensitivity. We tested the hypothesis that a relationship exists between active clinical manifestations of BS and the pathergy-positivity when performed simultaneously. Pathergy test and detailed dermatologic examination were done in 105 BS patients (60M\/45F); who were seen consecutively at the multi-disciplinary BS outpatient clinic in a single tertiary center. Information regarding demographic and clinical characteristics, pathergy test results at diagnosis, and details about treatment were obtained from patient charts. Disease activity was assessed using Beh\u00e7et Disease Current Activity Form. Among 105 patients, 27 (25.7%) were pathergy-positive at the time of the study visit whereas 40.9% were pathergy-positive at the time of the diagnosis. There was no relation between pathergy test and patient age or disease duration, either. Pathergy-positivity was significantly more common in patients with folliculitis compared to those without folliculitis (40.7% vs 19.2%; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.026). The test was also positive in all 3 patients with leg ulcers due to venous stasis. We found that among all skin-mucosa lesions only the presence of folliculitis was associated with pathergy positivity with statistical significance. It was also remarkable that the current pathergy was positive in all 3 patients with active leg ulcers but this finding warrants further studies because of the low patient numbers.<\/jats:p>","DOI":"10.1097\/md.0000000000037553","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T18:02:39Z","timestamp":1711994559000},"page":"e37553","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Folliculitis might be associated with pathergy-positivity in patients with Beh\u00e7et syndrome"],"prefix":"10.1097","volume":"103","author":[{"given":"Zeynep","family":"Altan Ferhato\u011flu","sequence":"first","affiliation":[{"name":"Department of Dermatology Istanbul, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dursun Dorukhan","family":"Altini\u015fik","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Orhangazi State Hospital, Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"\u00d6zdede","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defne","family":"\u00d6zkoca","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ko\u00e7 University, School of Medicine, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabriye","family":"G\u00fcner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5946-5230","authenticated-orcid":false,"given":"Kadir Atacan","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Istanbul, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekayi","family":"Kutlubay","sequence":"additional","affiliation":[{"name":"Department of Dermatology Istanbul, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emire","family":"Seyahi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Hamuryudan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250503","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s41927-020-00172-1","article-title":"Diagnosis of Beh\u00e7et\u2019s disease: clinical characteristics, diagnostic criteria, and differential diagnoses.","volume":"5","author":"Kiafar","year":"2021","journal-title":"BMC Rheumatol"},{"key":"R2-20250503","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/jdv.12107","article-title":"The International Criteria for Beh\u00e7et\u2019s Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new 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