{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:21:59Z","timestamp":1779294119389,"version":"3.51.4"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,29]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>The development and current state of hemorrhagic fever with renal syndrome (HFRS) over the past 40 years are analyzed in this study, along with explored and discovered the hotspots and frontiers in the field, which serve as the foundation for future investigation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>CiteSpace and VOSviewer analysis software were used to visually analyze the literature data on HFRS from 1980 to 2022, including the annual number of publications, countries and research institutions, authors, co-cited literature and keywords.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The number of pertinent papers published in the field of HFRS displayed an overall upward trend from 1980 to 2022. The United States, China, Germany, Sweden, and France are the top 5 countries in terms of publishing volume, with high intermediate centrality mainly concentrated in Europe and the United States. The top 10 co-occurring keywords were hemorrhagic fever, renal syndrome, infection, virus, epidemic, nephropathia epidemical, disease, hantavirus, outbreak, and transmission. According to keyword cluster analysis, there were 4 main research fields. In the HFRS-related study, there were mainly 21 notable keywords and \u201cKorean hemorrhagic fever\u201d had the highest hemorrhagic value (28.87).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>The United States, China, Germany, Sweden and other countries attached great importance to the HFRS-related research. Moreover, the collaboration between authors and institutions in various collaborator clusters should be strengthened. In recent decades, investigations have focused on the study of viral infection and the clinical symptoms and pathophysiology of HFRS. Future research may concentrate on factors affecting host population distribution and density, such as vaccine development and meteorological factors pertaining to virus transmission.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000037586","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T18:03:35Z","timestamp":1711735415000},"page":"e37586","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Visual analysis of global hemorrhagic fever with renal syndrome research from 1980 to 2022: Based on CiteSpace and VOSviewer"],"prefix":"10.1097","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8066-544X","authenticated-orcid":false,"given":"Wenfang","family":"Zhou","sequence":"first","affiliation":[{"name":"Young Scientific Research and Innovation Team of Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, Jiangxi Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghai","family":"Dong","sequence":"additional","affiliation":[{"name":"Young Scientific Research and Innovation Team of Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, Jiangxi Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Si","sequence":"additional","affiliation":[{"name":"Young Scientific Research and Innovation Team of Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, Jiangxi Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Young Scientific Research and Innovation Team of Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, Jiangxi Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Young Scientific Research and Innovation Team of Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, Jiangxi Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaona","family":"Chen","sequence":"additional","affiliation":[{"name":"Young Scientific Research and Innovation Team of Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, Jiangxi Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Ye","sequence":"additional","affiliation":[{"name":"Young Scientific Research and Innovation Team of Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, Jiangxi Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20250503","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/infdis\/146.5.638","article-title":"Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats.","volume":"146","author":"Lee","year":"1982","journal-title":"J Infect Dis"},{"key":"R2-20250503","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.antiviral.2012.05.011","article-title":"Dobrava-Belgrade virus: phylogeny, epidemiology, disease.","volume":"95","author":"Papa","year":"2012","journal-title":"Antiviral Res"},{"key":"R3-20250503","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/infdis\/137.3.298","article-title":"Isolation of the etiologic agent of Korean hemorrhagic fever.","volume":"137","author":"Lee","year":"1978","journal-title":"J Infect Dis"},{"key":"R4-20250503","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0923-2516(06)80106-8","article-title":"A study of nephropathia epidemica among military personnel in Sweden.","volume":"143","author":"Niklasson","year":"1992","journal-title":"Res Virol"},{"key":"R5-20250503","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3201\/eid0302.970202","article-title":"A global disease problem.","volume":"3","author":"Schmaljohn","year":"1997","journal-title":"Emerg Infect Dis"},{"key":"R6-20250503","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10393-017-1305-2","article-title":"Global diversity and distribution of hantaviruses and their hosts.","volume":"15","author":"Milholland","year":"2018","journal-title":"Ecohealth"},{"key":"R7-20250503","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3851\/IMP3036","article-title":"Successful treatment of rapidly progressing severe fever with thrombocytopenia syndrome with neurological complications using intravenous immunoglobulin and corticosteroid.","volume":"21","author":"Kim","year":"2016","journal-title":"Antivir Ther"},{"key":"R8-20250503","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S1473-3099(18)30293-7","article-title":"Epidemiological and clinical features of laboratory-diagnosed severe fever with thrombocytopenia syndrome in China, 2011\u201317: a prospective observational study.","volume":"18","author":"Li","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"R9-20250503","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijid.2013.08.011","article-title":"Plasma exchange and ribavirin for rapidly progressive severe fever with thrombocytopenia syndrome.","volume":"18","author":"Oh","year":"2014","journal-title":"Int J Infect Dis"},{"key":"R10-20250503","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.3201\/eid2207.151791","article-title":"Use of plasma therapy for severe fever with thrombocytopenia syndrome encephalopathy.","volume":"22","author":"Park","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"R11-20250503","doi-asserted-by":"crossref","first-page":"e0007308","DOI":"10.1371\/journal.pntd.0007308","article-title":"Severe fever with thrombocytopenia syndrome can masquerade as hemorrhagic fever with renal syndrome.","volume":"13","author":"Qi","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"R12-20250503","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jcv.2016.03.017","article-title":"The prospective evaluation of viral loads in patients with severe fever with thrombocytopenia syndrome.","volume":"78","author":"Yang","year":"2016","journal-title":"J Clin Virol"},{"key":"R13-20250503","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.vaccine.2018.02.049","article-title":"A bibliometric analysis of systematic reviews on vaccines and immunisation.","volume":"36","author":"Fernandes","year":"2018","journal-title":"Vaccine"},{"key":"R14-20250503","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.intimp.2019.03.045","article-title":"Bibliometric analysis of global research on PD-1 and PD-L1 in the field of cancer.","volume":"72","author":"Gao","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"R15-20250503","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.aap.2018.06.010","article-title":"Visualization and analysis of mapping knowledge domain of road safety studies.","volume":"118","author":"Zou","year":"2018","journal-title":"Accid Anal Prev"},{"issue":"suppl_1","key":"R16-20250503","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1073\/pnas.0307513100","article-title":"Searching for intellectual turning points: progressive knowledge domain visualization.","volume":"101","author":"Chen","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"R17-20250503","doi-asserted-by":"crossref","first-page":"e5477","DOI":"10.7717\/peerj.5477","article-title":"Trends in hepatocellular carcinoma research from 2008 to 2017: a bibliometric analysis.","volume":"6","author":"Miao","year":"2018","journal-title":"PeerJ"},{"key":"R18-20250503","doi-asserted-by":"crossref","first-page":"765193","DOI":"10.3389\/fneur.2021.765193","article-title":"Top 100 most-cited papers in neuropathic pain from 2000 to 2020: a bibliometric study.","volume":"12","author":"Xiong","year":"2021","journal-title":"Front Neurol"},{"key":"R19-20250503","doi-asserted-by":"crossref","first-page":"972357","DOI":"10.3389\/fonc.2022.972357","article-title":"Global research trends of artificial intelligence applied in esophageal carcinoma: a bibliometric analysis (2000-2022) via CiteSpace and VOSviewer.","volume":"12","author":"Tu","year":"2022","journal-title":"Front Oncol"},{"key":"R20-20250503","doi-asserted-by":"crossref","first-page":"823474","DOI":"10.3389\/fneur.2021.823474","article-title":"Epilepsy with suicide: a bibliometrics study and visualization analysis via CiteSpace.","volume":"12","author":"Guo","year":"2022","journal-title":"Front Neurol"},{"key":"R21-20250503","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping.","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics"},{"key":"R22-20250503","doi-asserted-by":"crossref","first-page":"105426","DOI":"10.1016\/j.nedt.2022.105426","article-title":"Mapping the research hotspots and theme trends of simulation in nursing education: a bibliometric analysis from 2005 to 2019.","volume":"116","author":"Wang","year":"2022","journal-title":"Nurse Educ Today"},{"key":"R23-20250503","doi-asserted-by":"crossref","first-page":"826341","DOI":"10.3389\/fpsyg.2022.826341","article-title":"Exploring inequality through service learning in higher education: a bibliometric review study.","volume":"13","author":"Mart\u00ednez-Heredia","year":"2022","journal-title":"Front Psychol"},{"key":"R24-20250503","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000067924","article-title":"Emerging viruses: the case \u201cHantavirus.\u201d.","volume":"45","author":"Ulrich","year":"2003","journal-title":"Intervirology"},{"key":"R25-20250503","first-page":"97","article-title":"Hantaviruses: an overview.","volume":"52","author":"Simmons","year":"2002","journal-title":"Comp Med"},{"key":"R26-20250503","first-page":"466","article-title":"The epidemic characteristics and preventive measures of hemorrhagic fever with syndromes in China.","volume":"25","author":"Zhang","year":"2004","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"R27-20250503","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ijid.2015.02.010","article-title":"Transmission of haemorrhagic fever with renal syndrome in China and the role of climate factors: a review.","volume":"33","author":"Hansen","year":"2015","journal-title":"Int J Infect Dis"},{"key":"R28-20250503","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.3346\/jkms.2013.28.10.1552","article-title":"Epidemiology of hemorrhagic fever with renal syndrome in Korea, 2001\u20132010.","volume":"28","author":"Lee","year":"2013","journal-title":"J Korean Med Sci"},{"key":"R29-20250503","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3349\/ymj.2001.42.3.278","article-title":"Primary humoral immune responses to formalin inactivated hemorrhagic fever with renal syndrome vaccine (Hantavax\u00ae): consideration of active immunization in South Korea.","volume":"42","author":"Sohn","year":"2001","journal-title":"Yonsei Med J"},{"key":"R30-20250503","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3947\/ic.2021.0148","article-title":"Hemorrhagic fever with renal syndrome: literature review, epidemiology, clinical picture and pathogenesis.","volume":"54","author":"Tariq","year":"2022","journal-title":"Infect Chemother"},{"key":"R31-20250503","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.3390\/v13081452","article-title":"Hantavirus research in Finland: highlights and perspectives.","volume":"13","author":"Vaheri","year":"2021","journal-title":"Viruses"},{"key":"R32-20250503","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.vaccine.2016.01.031","article-title":"Long-term immunogenicity and safety of inactivated Hantaan virus vaccine (Hantavax) in healthy adults.","volume":"34","author":"Song","year":"2016","journal-title":"Vaccine"},{"key":"R33-20250503","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.3201\/eid1912.131217","article-title":"Twenty-year summary of surveillance for human Hantavirus infections, United States.","volume":"19","author":"Knust","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"R34-20250503","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00281-017-0637-x","article-title":"Molecular pathogenesis of viral hemorrhagic fever.","volume":"39","author":"Basler","year":"2017","journal-title":"Semin Immunopathol"},{"key":"R35-20250503","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijid.2016.01.003","article-title":"Haemorrhagic fever with renal syndrome: literature review and distribution analysis in China.","volume":"43","author":"Zou","year":"2016","journal-title":"Int J Infect Dis"},{"key":"R36-20250503","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.4269\/ajtmh.18-0974","article-title":"Hemorrhagic fever with renal syndrome as a cause of acute diarrhea.","volume":"100","author":"Kim","year":"2019","journal-title":"Am J Trop Med Hyg"},{"key":"R37-20250503","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(20)31318-0","article-title":"Chronic pancreatitis.","volume":"396","author":"Beyer","year":"2020","journal-title":"Lancet"},{"key":"R38-20250503","doi-asserted-by":"crossref","first-page":"759198","DOI":"10.3389\/fmicb.2021.759198","article-title":"Viruses run: the evasion mechanisms of the antiviral innate immunity by Hantavirus.","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Microbiol"},{"key":"R39-20250503","doi-asserted-by":"crossref","first-page":"571984","DOI":"10.3389\/fpubh.2020.571984","article-title":"Analysis of hemorrhagic fever with renal syndrome using wavelet tools in Mainland China, 2004\u20132019.","volume":"8","author":"Zou","year":"2020","journal-title":"Front Public Health"},{"key":"R40-20250503","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1111\/1469-0691.12291","article-title":"Hantavirus infections.","volume":"21","author":"Avsic-Zupanc","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"R41-20250503","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s12879-021-05964-5","article-title":"Acute pancreatitis associated with hemorrhagic fever with renal syndrome: a cohort study of 346 patients.","volume":"21","author":"Guo","year":"2021","journal-title":"BMC Infect Dis"},{"key":"R42-20250503","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/s12967-019-2116-8","article-title":"Epitope-based peptide vaccine design and target site depiction against Middle East respiratory syndrome coronavirus: an immune-informatics study.","volume":"17","author":"Tahir Ul Qamar","year":"2019","journal-title":"J Transl Med"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000037586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T23:02:17Z","timestamp":1746313337000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000037586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,29]]},"references-count":42,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000037586","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,29]]}}}