{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:45:16Z","timestamp":1791542716202,"version":"4.3.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"38","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9,20]]},"abstract":"<jats:p>To observe the effect of low temperature plasma ablation combined with collagenase injection on lumbar disc herniation. 90 patients with lumbar disc herniation admitted to the pain department of our hospital and receiving surgical treatment from April 2021 to April 2023 were included in this retrospective study, and were divided into 2 groups according to different treatment plans. One group was treated with low-temperature plasma ablation combined with collagenase injection, and the other group was treated with low-temperature plasma ablation alone. The sample size of both groups was 80 cases. Peripheral blood was collected by fasting in the morning at 5 time points before surgery, 1, 3, 7 and 14 days after surgery, and 5\u2009mL of whole venous blood was collected by disposable vacuum blood collection device. Serum levels of pro-inflammatory factor interleukin (IL)-1\u03b1, IL-1\u03b2, IL-6, IL-8, tumor necrosis factor-\u03b1 and anti-inflammatory factor IL-4, IL-10 were detected by ELISA. VAS scores were used to evaluate postoperative low back pain. ODI and Lehmann Lumbar Function Scale were used to evaluate postoperative lumbar function. The contents of IL-1\u03b1, IL-1\u03b2, IL-6, IL-8, tumor necrosis factor-\u03b1 and anti-inflammatory factor IL-4, IL-10 in the cryo-plasma ablation combined with collagenase injection group were significantly lower than those in the cryo-plasma ablation group alone (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005&lt;\u2005.05). The VAS score of cryo-plasma ablation combined with collagenase injection group was significantly lower than that of cryo-plasma ablation group at 1 day and 3 months after treatment, and the difference was statistically significant (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005&lt;\u2005.05). The ODI score of cryo-plasma ablation combined with collagenase injection group was significantly lower than that of cryo-plasma ablation group at 1 day and 3 months after treatment, and the difference was statistically significant (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005&lt;\u2005.05). The Lehmann score of cryo-plasma ablation combined with collagenase injection group was significantly higher than that of cryo-plasma ablation group at 1 day and 3 months after treatment, and the difference was statistically significant (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005&lt;\u2005.05). The overall efficacy of low-temperature plasma ablation combined with collagenase injection is better than that of low-temperature plasma ablation alone. Low temperature plasma ablation combined with collagenase injection in the treatment of patients with lumbar disc herniation has less pain, faster recovery.<\/jats:p>","DOI":"10.1097\/md.0000000000039739","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T16:02:31Z","timestamp":1727107351000},"page":"e39739","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Clinical observation of low temperature plasma ablation combined with collagenase injection in lumbar disc herniation"],"prefix":"10.1097","volume":"103","author":[{"given":"Yulin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pain, Nanchong Central Hospital (Nanchong Hospital, Beijing Anzhen Hospital)\/The Second Clinical School of North Sichuan Medical College, Nanchong, Sichuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pain, Nanchong Central Hospital (Nanchong Hospital, Beijing Anzhen Hospital)\/The Second Clinical School of North Sichuan Medical College, Nanchong, Sichuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pain, Nanchong Central Hospital (Nanchong Hospital, Beijing Anzhen Hospital)\/The Second Clinical School of North Sichuan Medical College, Nanchong, Sichuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4268-5727","authenticated-orcid":false,"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pain, Nanchong Central Hospital (Nanchong Hospital, Beijing Anzhen Hospital)\/The Second Clinical School of North Sichuan Medical 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