{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:40:49Z","timestamp":1782978049092,"version":"3.54.5"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"38","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9,20]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Interleukin (IL)-6 is a major inflammatory cytokine that predicts mortality after out-of-hospital cardiac arrest (OHCA). Targeted temperature management (TTM) is associated with improved all-cause mortality in patients with OHCA. However, the effect of TTM on IL-6 production remains unclear. This study investigated whether TTM has additional anti-inflammatory effects after OHCA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This prospective cohort study included a total of 141 hospitalized patients with OHCA who were treated between January 2015 and June 2023. The study was conducted in the intensive care unit of China Medical University Hospital, Taichung. Postcardiac arrest care included TTM or the control approach (no TTM). The primary outcomes included the 90-day mortality rate and neurologic outcomes after OHCA. Differences between the TTM and control groups were examined using Student <jats:italic toggle=\"yes\">t<\/jats:italic> test, chi-square test, and Kaplan\u2013Meier survival curve analysis. Multivariate analysis of variance model was used to examine interaction effects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Plasma IL-6 and IL-6\/soluble IL-6 receptor complex levels were measured at 6 and 24 hours after resuscitation. IL-6 and IL-6\/soluble IL-6 receptor complex production was lower in the TTM group than in the control group (\u221250.0% vs +136.7%, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001; +26.3% vs +102.40%, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001, respectively). In addition, the 90-day mortality rate and poor neurologic outcomes were lower in the TTM group than in the control group (36.8% vs 63.0%, relative risk 0.39, 95% confidence interval 0.24\u20130.64, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001; 65.5% vs 81.5%, relative risk 0.80, 95% confidence interval 0.66\u20130.98, <jats:italic toggle=\"yes\">P<\/jats:italic> = .04).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>TTM improves both the mortality rate and neurologic outcomes in patients resuscitated from OHCA, possibly by reducing IL-6-induced proinflammatory responses.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000039780","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T16:02:27Z","timestamp":1727107347000},"page":"e39780","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Effect of targeted temperature management on systemic inflammatory responses after out-of-hospital cardiac arrest: A prospective cohort study"],"prefix":"10.1097","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-1564","authenticated-orcid":false,"given":"Dalong","family":"Chen","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7802-3829","authenticated-orcid":false,"given":"Yukai","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7924-5497","authenticated-orcid":false,"given":"Poyen","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung, Taiwan"},{"name":"Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5910-6469","authenticated-orcid":false,"given":"Jenjyh","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-0411","authenticated-orcid":false,"given":"Chihyang","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"},{"name":"Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-3982","authenticated-orcid":false,"given":"Gueijane","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan"},{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"},{"name":"Department of Medical Research, China Medical University Hospital, Taichung, Taiwan"},{"name":"Pharmacy Department, Wizcare Medical Corporation Aggregate, Taichung, Taiwan"},{"name":"School of Medicine, Weifang University of Science and Technology, Weifang, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6476-9896","authenticated-orcid":false,"given":"Kuan-Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"},{"name":"School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250503","first-page":"1","article-title":"Out-of-hospital cardiac arrest surveillance - cardiac arrest registry to enhance survival (CARES), United States, October 1, 2005-December 31, 2010.","volume":"60","author":"McNally","year":"2011","journal-title":"MMWR Surveill Summ"},{"key":"R2-20250503","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.recesp.2013.03.013","article-title":"Clinical characteristics and vital and functional prognosis of out-of-hospital cardiac arrest survivors admitted to five cardiac intensive care 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