{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:36:21Z","timestamp":1776134181161,"version":"3.50.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"45","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11,8]]},"abstract":"<jats:sec>\n            <jats:title>Rationale:<\/jats:title>\n            <jats:p>Nonhealing ulcers are difficult to manage because they deviate from the normal wound healing process. Conventional therapy cannot achieve satisfactory therapeutic effects. To verify the effectiveness of combined treatment with human umbilical cord mesenchymal stem cells (hUMSCs) and platelet-rich plasma (PRP) for nonhealing ulcers, we studied a patient with left lower limb venous ulcer (LEVU) treated with combined injection therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patient concerns:<\/jats:title>\n            <jats:p>We present the case of a LEVU patient who has not healed for a long period of time (up to 1 year).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Diagnoses:<\/jats:title>\n            <jats:p>LEVU was diagnosed with clinical symptoms.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interventions:<\/jats:title>\n            <jats:p>The hUMSCs plus PRP were injected into the wound edge and base (1 \u00b5L of cells\/cm<jats:sup>2<\/jats:sup> of wound surface), 0.5\u2009mL at each point, with a distance of approximately 1 to 3\u2009cm between points. The injection point was determined according to the extent of wound involvement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Outcomes:<\/jats:title>\n            <jats:p>Seven days after hUMSC\u2005+\u2005PRP application, the wound area decreased by nearly 50%. The ulcers had almost completely healed by day 62, and no serious treatment-related toxic side effects were observed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Lessons:<\/jats:title>\n            <jats:p>hUMSCs can improve wound healing through re-epithelialization, increased angiogenesis, and granulation tissue formation. PRP has also been suggested to promote wound healing through the secretion of various nutritional factors. The combination of hUMSCs and PRP has a mutually reinforcing effect, which may achieve a 1\u2005+\u20051\u2005&gt;\u20052 effect. Therefore, the combination of hUMSCs and PRP may be a safe and effective treatment option for LEVU.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000040433","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T20:02:58Z","timestamp":1731355378000},"page":"e40433","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Umbilical cord mesenchymal stem cells combined with autologous platelet-rich plasma for lower extremity venous ulcers: A case report and literature review"],"prefix":"10.1097","volume":"103","author":[{"given":"Linlin","family":"Jiao","sequence":"first","affiliation":[{"name":"Nursing Department, Liaocheng People\u2019s Hospital, Liaocheng, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Liaocheng People\u2019s Hospital, Liaocheng, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Liaocheng People\u2019s Hospital, Liaocheng, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Liaocheng People\u2019s Hospital, Liaocheng, Shandong Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9448-8738","authenticated-orcid":false,"given":"Yuanda","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Liaocheng People\u2019s Hospital, Liaocheng, Shandong Province, 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