{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T04:07:30Z","timestamp":1746331650981,"version":"3.40.4"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"51","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,20]]},"abstract":"<jats:sec>\n            <jats:title>Rationale:<\/jats:title>\n            <jats:p>Lateral epicondylitis, commonly known as tennis elbow, is a chronic condition characterized by tendinosis at the insertion site of the lateral epicondyle. Various treatment methods are available, ranging from conservative to surgical options for refractory lateral epicondylitis. Recently, platelet-rich plasma (PRP) injections have shown effectiveness for treating this condition. This study aimed to evaluate the effectiveness of injecting a mixture of allodermal matrix (ADM) and leukocyte-rich PRP (LRPRP) for tendon regeneration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patient concerns:<\/jats:title>\n            <jats:p>A 59-year-old man and a 62-year-old man, both with full-thickness tears in the common extensor tendon, presented persistent elbow pain despite undergoing several conservative treatments, including steroid injections, extracorporeal shock wave therapy, physical therapy, and medication previously.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Diagnoses:<\/jats:title>\n            <jats:p>The patients were diagnosed with refractory lateral epicondylitis using ultrasonography and magnetic resonance imaging (MRI).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interventions:<\/jats:title>\n            <jats:p>We performed injections of a mixture of ADM and LRPRP into the full-thickness tear of the common extensor tendon.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Outcomes:<\/jats:title>\n            <jats:p>One year after the procedure, visual analogue scale pain scores, patient-rated tennis elbow evaluation scores, quick disabilities of the arm, shoulder, and hand scores, and Nirschl scores had all improved significantly from baseline. In case 1, MRI scans obtained at 6 and 12 months postinjection demonstrated improved tendon integrity in full-thickness tear of the common extensor tendon. In case 2, similar improvements were observed on the 6-month postinjection MRI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Lessons:<\/jats:title>\n            <jats:p>Injection of a mixture of ADM and LRPRP at the site of full-thickness tears in the common extensor tendon of the elbow can enhance tendon integrity. This treatment also improves functional status in cases of recalcitrant lateral epicondylitis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000041002","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T20:03:19Z","timestamp":1734724999000},"page":"e41002","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Injection of an allodermal matrix and leukocyte-rich platelet-rich plasma mixture improved the tendon integrity in cases of full-thickness common extensor tendon tears of the elbow: Two case reports"],"prefix":"10.1097","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1614-4901","authenticated-orcid":false,"given":"Eun-Ji","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5475-1529","authenticated-orcid":false,"given":"Jong-Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20250503","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5435\/00124635-200801000-00004","article-title":"Management of lateral epicondylitis: current concepts.","volume":"16","author":"Calfee","year":"2008","journal-title":"J Am Acad Orthop Surg"},{"key":"R2-20250503","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/jpm13010066","article-title":"Ultrasound-guided injection of autologous platelet-rich plasma for refractory lateral epicondylitis of humerus: case series.","volume":"13","author":"Huang","year":"2022","journal-title":"J Pers Med"},{"key":"R3-20250503","first-page":"1","article-title":"PRP injection versus surgical method for treatment of tennis elbow: case report.","volume":"5","author":"Mehdizadeh","year":"2022","journal-title":"J Clin Lab Res"},{"key":"R4-20250503","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.otsr.2020.03.022","article-title":"Effect of atelocollagen on the healing status after medial meniscal root repair using the modified Mason-Allen stitch.","volume":"106","author":"Lee","year":"2020","journal-title":"Orthop Traumatol Surg Res"},{"key":"R5-20250503","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/j.arthro.2024.02.046","article-title":"Atelocollagen injection during arthroscopic rotator cuff repair for small- to medium-sized subacute or chronic rotator cuff tears enhances radiographic tendon integrity: a propensity score-matched comparative study.","volume":"40","author":"Kim","year":"2024","journal-title":"Arthroscopy"},{"key":"R6-20250503","doi-asserted-by":"crossref","first-page":"2325967120904012","DOI":"10.1177\/2325967120904012","article-title":"Atelocollagen injection improves tendon integrity in partial-thickness rotator cuff tears: a prospective comparative study.","volume":"8","author":"Kim","year":"2020","journal-title":"Orthop J Sports Med"},{"key":"R7-20250503","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1177\/03635465211030508","article-title":"Improved healing of rabbit patellar tendon defects after an atelocollagen injection.","volume":"49","author":"Kim","year":"2021","journal-title":"Am J Sports Med"},{"key":"R8-20250503","first-page":"67","article-title":"Bioengineered acellular dermal matrix for the repair of full thickness skin wounds in rats.","volume":"27","author":"Gangwar","year":"2013","journal-title":"Trends Biomater Artif Organs"},{"key":"R9-20250503","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/PRS.0b013e3182450ae5","article-title":"Metrics of cellular and vascular infiltration of human acellular dermal matrix in ventral hernia repairs.","volume":"129","author":"Campbell","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"R10-20250503","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.3390\/ijms25137088","article-title":"Human acellular collagen matrices\u2014Clinical opportunities in tissue replacement.","volume":"25","author":"Verboket","year":"2024","journal-title":"Int J Mol Sci"},{"key":"R11-20250503","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.arthro.2011.06.038","article-title":"A prospective, randomized evaluation of acellular human dermal matrix augmentation for arthroscopic rotator cuff repair.","volume":"28","author":"Barber","year":"2012","journal-title":"Arthroscopy"},{"key":"R12-20250503","first-page":"301","article-title":"Acellular dermal matrix in rotator cuff surgery.","volume":"45","author":"Cooper","year":"2016","journal-title":"Am J Orthop (Belle Mead NJ)"},{"key":"R13-20250503","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10561-017-9628-3","article-title":"Biological incorporation of human acellular dermal matrix used in Achilles tendon repair.","volume":"18","author":"Bertasi","year":"2017","journal-title":"Cell Tissue Bank"},{"key":"R14-20250503","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1186\/s12891-022-05758-z","article-title":"Validation of a novel magnetic resonance imaging classification and recommended treatment for lateral elbow tendinopathy.","volume":"23","author":"Tuntiyatorn","year":"2022","journal-title":"BMC Musculoskelet Disord"},{"key":"R15-20250503","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.jse.2022.01.147","article-title":"Repeated magnetic resonance imaging at 6 follow-up visits over a 2-year period after platelet-rich plasma injection in patients with lateral epicondylitis.","volume":"31","author":"Suzuki","year":"2022","journal-title":"J Shoulder Elbow Surg"},{"key":"R16-20250503","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jse.2021.10.036","article-title":"The effect of leucocyte concentration of platelet-rich plasma on outcomes in patients with lateral epicondylitis: a systematic review and meta-analysis.","volume":"31","author":"Shim","year":"2022","journal-title":"J Shoulder Elbow Surg"},{"key":"R17-20250503","doi-asserted-by":"crossref","first-page":"584","DOI":"10.32098\/mltj.04.2019.14","article-title":"Treatment of lateral epicondylitis with collagen injections: a pilot study.","volume":"09","author":"Corrado","year":"2019","journal-title":"Muscles Ligaments Tendons J"},{"key":"R18-20250503","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1177\/0363546510397173","article-title":"Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up.","volume":"39","author":"Gosens","year":"2011","journal-title":"Am J Sports Med"},{"key":"R19-20250503","first-page":"RC05","article-title":"Comparison of local injection of platelet rich plasma and corticosteroids in the treatment of lateral epicondylitis of humerus.","volume":"9","author":"Yadav","year":"2015","journal-title":"J Clin Diagn Res"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000041002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:28:21Z","timestamp":1746318501000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000041002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":19,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000041002","relation":{},"ISSN":["1536-5964"],"issn-type":[{"type":"electronic","value":"1536-5964"}],"subject":[],"published":{"date-parts":[[2024,12,20]]}}}