{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:05:46Z","timestamp":1789146346396,"version":"build-2803163510"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"52","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangxi Medical and Health Appropriate Technology Development, Popularization, and Application Project","award":["s2017031"],"award-info":[{"award-number":["s2017031"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,27]]},"abstract":"<jats:p>\n                    This study aims to explore predictors of high-grade atherosclerotic renal artery stenosis (ARAS) in patients with chronic kidney disease (CKD). This was a retrospective study, and univariate analysis such as independent-sample t test or nonparametric test where appropriate was used to explore variables with significant difference between patients with high-grade ARAS and patients with low-grade ARAS. Then, multivariate logistic regression and receiver operating characteristic curve (ROC) analysis were performed for further research. In univariate analysis, we found that there was a significant difference in smoking history, estimated glomerular filtration rate (eGFR), cystatin C, fasting blood glucose and lymphocyte-to-monocyte ratio (LMR) between the 2 groups. Multivariate logistic regression analysis showed that eGFR (OR\u2005=\u20050.979, 95% CI: 0.962\u20130.996,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.017), cystatin C (OR\u2005=\u20052.123, 95% CI: 1.118\u20134.030,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.021) and LMR (OR\u2005=\u20050.639, 95% CI: 0.421\u20130.969,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.035) were still associated with high-grade ARAS in patients with CKD. ROC analysis showed that eGFR (AUC: 0.681; sensitivity: 64.1%, specificity: 65.1%), cystatin C (AUC: 0.658; sensitivity: 74.6%, specificity: 53.85%) and LMR (AUC: 0.650; sensitivity: 66.70%, specificity: 62.00%). In patients with CKD, eGFR, and cystatin C and LMR were predictive parameters of high-grade ARAS, and among them, eGFR and LMR held the greatest predictive value for high-grade ARAS in patients with CKD.\n                  <\/jats:p>","DOI":"10.1097\/md.0000000000041007","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T21:02:41Z","timestamp":1735592561000},"page":"e41007","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of high-grade atherosclerotic renal artery stenosis in patients with CKD"],"prefix":"10.1097","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4071-7906","authenticated-orcid":false,"given":"Jun","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kequan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guangxi Medical University, Nanning, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8678-6371","authenticated-orcid":false,"given":"Jiangnan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260911","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1046\/j.1523-1755.1998.00805.x","article-title":"Risk of atrophy in kidneys with atherosclerotic renal artery stenosis.","volume":"53","author":"Caps","year":"1998","journal-title":"Kidney Int"},{"key":"R2-20260911","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0272-6386(12)80224-1","article-title":"Natural history of renal artery stenosis.","volume":"24","author":"Strandness","year":"1994","journal-title":"Am J Kidney Dis"},{"key":"R3-20260911","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.HYP.23.3.346","article-title":"Renal atrophy and arterial stenosis. 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