{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:20:09Z","timestamp":1790889609152,"version":"4.1.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,17]]},"abstract":"\n Rationale:<\/jats:title>\n Patients with extensive small cell lung cancer (SCLC) generally have a dismal survival rate and are conventionally treated with chemotherapy. This study aimed to explore an alternative treatment approach by combining traditional Chinese medicine (TCM) with radiotherapy and chemotherapy.<\/jats:p>\n <\/jats:sec>\n \n Patient concerns:<\/jats:title>\n A 68-year-old male was diagnosed with extensive-stage SCLC. Positron emission tomography\/computed tomography scans indicated a high metabolism mass in the left hilar region, along with multiple lymph node metastases and metastatic tumors in both lungs. A left lung biopsy verified small cell carcinoma.<\/jats:p>\n <\/jats:sec>\n \n Diagnoses:<\/jats:title>\n The patient was confirmed to have extensive stage SCLC based on imaging and biopsy results.<\/jats:p>\n <\/jats:sec>\n \n Interventions:<\/jats:title>\n The patient received a comprehensive treatment regimen. TCM herbal prescriptions such as Qianjin Weijing Decoction, Wuwei Xiaodu Decoction, Xiaoxianxiong Decoction, and Xiaochengqi Decoction were administered. In parallel, standard Western medicine therapies, including chemotherapy (intravenous cisplatin and etoposide) and radiotherapy, were carried out. Oral ondansetron was given to alleviate nausea and vomiting caused by chemotherapy and radiotherapy.<\/jats:p>\n <\/jats:sec>\n \n Outcomes:<\/jats:title>\n After 30 months, follow-up positron emission tomography\/computed tomography demonstrated the complete disappearance of all cancerous lesions. The patient regained normal daily activities and experienced a substantially enhanced quality of life. Four years after the initial treatment, there has been no recurrence, and the patient persists in taking the original TCM decoction.<\/jats:p>\n <\/jats:sec>\n \n Lessons:<\/jats:title>\n The combination of TCM and Western medicine in treating SCLC proves effective in managing systemic symptoms, mitigating bone marrow suppression, gastrointestinal reactions, immunosuppression, and other chemotherapy-induced adverse reactions. It also significantly prolongs the survival period, suggesting it as a preferable treatment option for SCLC.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/md.0000000000041291","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T03:00:50Z","timestamp":1737428450000},"page":"e41291","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Extensive small cell lung cancer treated by integrated traditional Chinese and Western medicine: A case report"],"prefix":"10.1097","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-9406","authenticated-orcid":false,"given":"Yuanqing","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250121","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/107327480801500205","article-title":"Molecular analysis-based treatment strategies for non-small cell lung cancer.","volume":"15","author":"Bepler","year":"2008","journal-title":"Cancer Control"},{"key":"R2-20250121","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.3390\/cancers11091297","article-title":"Tumor-targeted drug conjugates as an emerging novel therapeutic approach in small cell lung cancer (SCLC).","volume":"11","author":"Deneka","year":"2019","journal-title":"Cancers"},{"key":"R3-20250121","first-page":"407","article-title":"Molecular diagnostics of lung cancer and its research progress.","volume":"39","author":"Wei","year":"2019","journal-title":"Chin J Pract Intern Med"},{"key":"R4-20250121","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1200\/JCO.2005.04.4859","article-title":"Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database.","volume":"24","author":"Govindan","year":"2006","journal-title":"J Clin Oncol"},{"key":"R5-20250121","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2217\/fon-2015-0012","article-title":"Immunotherapy for small-cell lung cancer: emerging evidence.","volume":"12","author":"Reck","year":"2016","journal-title":"Future Oncol"},{"key":"R6-20250121","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1186\/s13063-020-04275-5","article-title":"Efficacy and safety of Shengjiang Xiexin decoction in prophylaxis of chemotherapy-related diarrhea in small cell lung cancer patients: Study protocol for a multicenter randomized controlled trial.","volume":"21","author":"Deng","year":"2020","journal-title":"Trials"},{"issue":"5 Suppl","key":"R7-20250121","doi-asserted-by":"crossref","first-page":"e400S","DOI":"10.1378\/chest.12-2363","article-title":"Treatment of small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.","volume":"143","author":"Jett","year":"2013","journal-title":"Chest"},{"key":"R8-20250121","first-page":"601067","article-title":"Chinese herbal decoction based on syndrome differentiation as maintenance therapy in patients with extensive-stage small-cell lung cancer: an exploratory and small prospective cohort study.","volume":"2015","author":"Liu","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"R9-20250121","first-page":"884","article-title":"Analysis of the mechanism of action and anti-tumor prescriptions of commonly used anti-tumor Chinese medicines in clinical practice.","volume":"18","author":"Wang","year":"2020","journal-title":"Oncol Prog"},{"key":"R10-20250121","first-page":"2587","article-title":"Research of anti-tumor activity and mechanism of Chinese materia medica active ingredients.","volume":"51","author":"Li","year":"2020","journal-title":"Chin Tradit Herb Drugs"},{"key":"R11-20250121","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1007\/s00432-020-03353-0","article-title":"Efficacy and safety of TCM combined with chemotherapy for SCLC: a systematic review and meta-analysis.","volume":"146","author":"Chen","year":"2020","journal-title":"J Cancer Res Clin Oncol"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000041291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T03:00:54Z","timestamp":1737428454000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000041291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,17]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000041291","relation":{},"ISSN":["1536-5964"],"issn-type":[{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,17]]}}}