{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T18:23:13Z","timestamp":1794248593803,"version":"4.9.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3,21]]},"abstract":"\n This study investigates the therapeutic effect of montelukast sodium combined with budesonide in children with cough variant asthma (CVA) and its influence on the levels of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). A total of 112 children with CVA treated in our hospital from January 2019 to January 2021 were selected. According to the different treatment methods, they were divided into control group and experimental group, and the clinical data of each group were collected retrospectively. The control group was treated with budesonide, and the study group was treated with Montelukast sodium combined with budesonide. The clinical therapeutic effect, lung function level, adverse reactions and inflammatory factors were compared between the 2 groups. The effective rate in the study group was 92.9%, compared to 73.2% in the control group, with the study group showing significantly higher rates (\n P<\/jats:italic>\n \u2005<\u2005.05). There was no significant difference in pulmonary function index levels between the 2 groups before drug intervention (\n P<\/jats:italic>\n \u2005>\u2005.05), but levels of all indexes improved after treatment. The levels of FEV1, FVC, peak expiratory flow, and FEV1\/FVC in the study group were higher than those in the control group (\n P<\/jats:italic>\n \u2005<\u2005.05). The incidence of adverse reactions such as nausea, rash, and headache was 25.0% in the study group and 23.2% in the control group, with no significant difference between the 2 groups (\n P<\/jats:italic>\n \u2005>\u2005.05). Before treatment, there was no significant difference in the levels of inflammatory factors between the 2 groups (\n P<\/jats:italic>\n \u2005>\u2005.05). After treatment, levels of TNF-\u03b1, IL-6, and IgE improved in both groups, with the study group showing lower levels than the control group (\n P<\/jats:italic>\n \u2005<\u2005.05). Montelukast sodium combined with budesonide in the treatment of children with CVA enhances the treatment effect, improves pulmonary function, inhibits inflammatory factors, and does not increase adverse drug reactions, making it a valuable treatment option.\n <\/jats:p>","DOI":"10.1097\/md.0000000000041371","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T23:31:16Z","timestamp":1743031876000},"page":"e41371","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic efficacy of montelukast sodium combined with budesonide in children with cough variant asthma: Impact on FEV1 and FVC levels"],"prefix":"10.1097","volume":"104","author":[{"given":"Yingying","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The First People\u2019s Hospital of Taizhou City, Taizhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First People\u2019s Hospital of Taizhou City, Taizhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First People\u2019s Hospital of Taizhou City, Taizhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4979-2284","authenticated-orcid":false,"given":"Benben","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First People\u2019s Hospital of Taizhou City, Taizhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20261109","first-page":"95","article-title":"Clinical observation of fluticasone propionate, montelukast sodium and ketotifen in the 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remodeling in children with asthma.","volume":"35","author":"Liu","year":"2019","journal-title":"Chin J Clin Pharmacol"},{"key":"R13-20261109","first-page":"220","article-title":"Effect of Fengxiao decoction on allergic asthma and its influence on serum TIgE, IgG4 and ECP.","volume":"37","author":"Li","year":"2019","journal-title":"Chin J Traditional Chin Med"},{"key":"R14-20261109","first-page":"481","article-title":"Clinical study of treating cough variant asthma with guomin decoction combined with budesonide and.","volume":"85","author":"Xiaokai","year":"2019","journal-title":"Chin Foreign Med Res"},{"key":"R15-20261109","first-page":"106","article-title":"Clinical efficacy of montelukast sodium combined with budesonide or combined with loratadine in treating children with cough variant asthma and influence on inflammatory factors in the serum.","volume":"36","author":"Wei","year":"2019","journal-title":"Exp Ther Med"},{"key":"R16-20261109","first-page":"1053","article-title":"Effect of montelukast sodium combined with loratadine on serum and induced sputum inflammatory mediators in children with cough variant asthma.","volume":"16","author":"Liu","year":"2019","journal-title":"Lab Med Clin"},{"key":"R17-20261109","first-page":"574","article-title":"lncRNA PCGEM1 strengthens anti-inflammatory and lung protective effects of montelukast sodium in children with Brazilian.","volume":"53","author":"Xu","year":"2020","journal-title":"J Med Biol Res"},{"key":"R18-20261109","first-page":"2207","article-title":"Effect of montelukast sodium combined with cetirizine hydrochloride in the treatment of children with cough variant asthma and its effect on serum NT-3 and EOS levels.","volume":"24","author":"Hu","year":"2019","journal-title":"J Clin Pulmonol"},{"key":"R19-20261109","first-page":"48","article-title":"Clinical analysis of montelukast sodium in the treatment of children with asthmatic bronchitis.","volume":"56","author":"Jun-Hua","year":"2019","journal-title":"Smart Healthc"},{"key":"R20-20261109","first-page":"86","article-title":"Clinical efficacy, pulmonary function and safety of montelukast sodium and cetirizine combined with budesonide in children with cough variant asthma.","volume":"41","author":"Ding","year":"2020","journal-title":"J Kunming Med 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