{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:36:28Z","timestamp":1792708588364,"version":"4.5.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4,25]]},"abstract":"<jats:sec>\n            <jats:title>Rationale:<\/jats:title>\n            <jats:p>Generalized pustular psoriasis (GPP) is a severe form of pustular psoriasis, which can endanger the patient life. However, the conventional treatment for GPP presents several limitations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patient Concerns:<\/jats:title>\n            <jats:p>In this report, we present a 54-year-old male patient with GPP and chronic hepatitis B. The use of glucocorticoids and acitretin for GPP caused liver injury in our case.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Diagnoses:<\/jats:title>\n            <jats:p>The patient was diagnosed with GPP with chronic hepatitis B.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interventions:<\/jats:title>\n            <jats:p>The patient accepted traditional therapy, including glucocorticoids and acitretin. The use of glucocorticoids and acitretin for GPP caused liver injury in our case. Therefore, acitretin was discontinued (but not the glucocorticoid). After excluding contraindications, the patient was administered a single dose of spesolimab (900\u2009mg).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Outcomes:<\/jats:title>\n            <jats:p>The rash resolved within 48 hours after the patient was administered a single dose of spesolimab (900\u2009mg).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Lessons:<\/jats:title>\n            <jats:p>Our study shows that spesolimab could be employed as a safe and effective therapeutic option for patients with GPP and other underlying conditions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000041979","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T23:01:01Z","timestamp":1745881261000},"page":"e41979","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Successful treatment of generalized pustular psoriasis with chronic hepatitis B using spesolimab: A case report"],"prefix":"10.1097","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8623-4813","authenticated-orcid":false,"given":"Ruiyuan","family":"Ming","sequence":"first","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincai","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250904","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.3390\/ijms20071649","article-title":"IL-36 cytokines: regulators of inflammatory responses and their emerging role in immunology of reproduction.","volume":"20","author":"Murrieta-Coxca","year":"2019","journal-title":"Int J Mol Sci"},{"key":"R2-20250904","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jaci.2016.08.056","article-title":"IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis.","volume":"140","author":"Johnston","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"R3-20250904","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/exd.14765","article-title":"Current management of generalized pustular psoriasis.","volume":"32","author":"Kodali","year":"2023","journal-title":"Exp Dermatol"},{"key":"R4-20250904","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMoa2111563","article-title":"Trial of spesolimab for generalized pustular psoriasis.","volume":"385","author":"Bachelez","year":"2021","journal-title":"N Engl J Med"},{"key":"R5-20250904","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.3390\/ijms22094344","article-title":"Exploring the role of IL-36 cytokines as a new target in psoriatic disease.","volume":"22","author":"Iznardo","year":"2021","journal-title":"Int J Mol Sci"},{"key":"R6-20250904","doi-asserted-by":"crossref","first-page":"1462158","DOI":"10.3389\/fimmu.2024.1462158","article-title":"Biologics for generalized pustular psoriasis: a systematic review and single-arm meta-analysis.","volume":"15","author":"Chen","year":"2024","journal-title":"Front Immunol"},{"key":"R7-20250904","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00105-023-05140-7","article-title":"Remission of recalcitrant generalized pustular psoriasis under interleukin-36 receptor inhibitor spesolimab.","volume":"74","author":"M\u00fcller","year":"2023","journal-title":"Dermatologie (Heidelb)"},{"key":"R8-20250904","doi-asserted-by":"crossref","first-page":"2334791","DOI":"10.1080\/09546634.2024.2334791","article-title":"Successful treatment of recalcitrant generalized pustular psoriasis of pregnancy with spesolimab.","volume":"35","author":"Yang","year":"2024","journal-title":"J Dermatolog Treat"},{"key":"R9-20250904","doi-asserted-by":"crossref","first-page":"1338285","DOI":"10.3389\/fimmu.2024.1338285","article-title":"Successful treatment of acrodermatitis continua of Hallopeau coexisting with generalized pustular psoriasis with spesolimab: a case report.","volume":"15","author":"Wen","year":"2024","journal-title":"Front Immunol"},{"key":"R10-20250904","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1111\/1346-8138.17032","article-title":"A case of generalized pustular psoriasis with discrepant resolution time between pustules and erythema after treatment with spesolimab.","volume":"51","author":"Matsuo","year":"2024","journal-title":"J Dermatol"},{"key":"R11-20250904","doi-asserted-by":"crossref","first-page":"e335","DOI":"10.1111\/1346-8138.17243","article-title":"A case of generalized pustular psoriasis complicated with SLE successfully treated with spesolimab.","volume":"51","author":"Minami","year":"2024","journal-title":"J Dermatol"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000041979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T12:04:29Z","timestamp":1756987469000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000041979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":11,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000041979","relation":{},"ISSN":["1536-5964"],"issn-type":[{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]}}}