{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T03:28:07Z","timestamp":1769225287450,"version":"3.49.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,23]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The effectiveness and safety of polyphenols in treating ulcerative colitis remain controversial. This study aimed to evaluate the efficacy and safety of polyphenols in the treatment of ulcerative colitis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This study followed the preferred reporting items for systematic reviews and meta-analyses 2020 guidelines. A systematic search was conducted across PubMed, Embase, Web of Science, and Cochrane databases to identify relevant articles. The random-effects model was employed to calculate the odds ratio (OR) and corresponding 95% confidence intervals (CIs).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A total of 13 trials involving 742 participants were included in the meta-analysis. The clinical remission rates were higher in the polyphenol group compared to the control group, as demonstrated by both the intention-to-treat (ITT) (OR: 4.71; 95% CI: 2.02\u201310.99; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.000) and per-protocol (PP) analysis (OR: 7.14; 95% CI: 3.11\u201316.39; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.000). Similarly, the clinical response rate was higher in the polyphenol group compared to the control group, according to the ITT (OR: 5.40; 95% CI: 2.60\u201311.24; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.000) and PP analysis (OR: 9.14; 95% CI: 4.25\u201319.64; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.000). Moreover, the total endoscopic remission rate was superior in the polyphenol group, as indicated by the ITT (OR: 3.16; 95% CI: 1.20\u20138.37; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.020) and PP analysis (OR: 4.92; 95% CI: 2.03\u201311.93; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.000). No significant differences were observed regarding side effects between the 2 groups, according to the ITT (OR: 0.99; 95% CI: 0.56\u20131.76; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.973) and PP analysis (OR: 0.99; 95% CI: 0.54\u20131.80; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.971).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Polyphenols demonstrated effectiveness in inducing clinical remission, clinical response, and endoscopic remission in patients with ulcerative colitis. Furthermore, there was no evidence of a higher incidence of adverse effects associated with their use.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/md.0000000000041985","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T04:00:08Z","timestamp":1748318408000},"page":"e41985","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of polyphenols in adjuvant treating ulcerative colitis: A meta-analysis of randomized controlled trials"],"prefix":"10.1097","volume":"104","author":[{"given":"Qiuxiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Guangyuan Central Hospital, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Zigong First People\u2019s Hospital, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Traditional Chinese Medicine of Yibin City, Sichuan Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongguo","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Guangyuan Central Hospital, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20250527","doi-asserted-by":"crossref","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","article-title":"ACG clinical guideline: ulcerative colitis in adults.","volume":"114","author":"Rubin","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"R2-20250527","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"R3-20250527","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jama.2023.15389","article-title":"Ulcerative colitis in adults: a review.","volume":"330","author":"Gros","year":"2023","journal-title":"JAMA"},{"key":"R4-20250527","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1440-1746.2006.04140.x","article-title":"Retrospective analysis of 515 cases of Crohn\u2019s disease hospitalization in China: nationwide study from 1990 to 2003.","volume":"21","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"R5-20250527","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis.","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"key":"R6-20250527","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.cgh.2022.06.030","article-title":"Global hospitalization trends for crohn\u2019s disease and ulcerative colitis in the 21st century: a systematic review with temporal analyses.","volume":"21","author":"Buie","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R7-20250527","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2147\/CLEP.S402718","article-title":"Temporal trends of inflammatory bowel disease burden in China from 1990 to 2030 with comparisons to Japan, South Korea, the European Union, the United States of America, and the World.","volume":"15","author":"Ma","year":"2023","journal-title":"Clin Epidemiol"},{"key":"R8-20250527","doi-asserted-by":"crossref","first-page":"e20629","DOI":"10.2196\/20629","article-title":"Economic burden and health care access for patients with inflammatory bowel diseases in China: web-based survey study.","volume":"23","author":"Yu","year":"2021","journal-title":"J Med Internet Res"},{"key":"R9-20250527","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41575-022-00634-6","article-title":"Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment.","volume":"19","author":"Bisgaard","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"R10-20250527","doi-asserted-by":"crossref","first-page":"e062932","DOI":"10.1136\/bmjopen-2022-062932","article-title":"Effect of polyphenol compounds on Helicobacter pylori eradication: a systematic review with meta-analysis.","volume":"13","author":"Wang","year":"2023","journal-title":"BMJ Open"},{"key":"R11-20250527","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.autrev.2019.05.001","article-title":"Polyphenols in the treatment of autoimmune diseases.","volume":"18","author":"Khan","year":"2019","journal-title":"Autoimmun Rev"},{"key":"R12-20250527","doi-asserted-by":"crossref","first-page":"9552","DOI":"10.1002\/jcb.27273","article-title":"The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients\u2019 self-reported well-being: a randomized double-blind controlled trial.","volume":"119","author":"Masoodi","year":"2018","journal-title":"J Cell Biochem"},{"key":"R13-20250527","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4292\/wjgpt.v8.i2.147","article-title":"Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: results from a randomized double blind placebo controlled trial.","volume":"8","author":"Kedia","year":"2017","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"R14-20250527","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.crohns.2013.08.006","article-title":"Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis - a randomized, placebo-controlled, pilot study.","volume":"8","author":"Singla","year":"2014","journal-title":"J Crohns Colitis"},{"key":"R15-20250527","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/MCG.0000000000001416","article-title":"Novel bioenhanced curcumin with mesalamine for induction of clinical and endoscopic remission in mild-to-moderate ulcerative colitis: a randomized double-blind placebo-controlled pilot study.","volume":"55","author":"Banerjee","year":"2021","journal-title":"J Clin Gastroenterol"},{"key":"R16-20250527","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/ptr.6581","article-title":"The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis.","volume":"34","author":"Sadeghi","year":"2020","journal-title":"Phytother Res"},{"key":"R17-20250527","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.cgh.2006.08.008","article-title":"Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial.","volume":"4","author":"Hanai","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R18-20250527","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.cgh.2015.02.019","article-title":"Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial.","volume":"13","author":"Lang","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R19-20250527","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.arcmed.2016.07.003","article-title":"Resveratrol supplementation and oxidative\/anti-oxidative status in patients with ulcerative colitis: a randomized, double-blind, placebo-controlled pilot study.","volume":"47","author":"Samsamikor","year":"2016","journal-title":"Arch Med Res"},{"key":"R20-20250527","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.arcmed.2015.05.005","article-title":"Anti-inflammatory effects of resveratrol in patients with ulcerative colitis: a randomized, double-blind, placebo-controlled pilot study.","volume":"46","author":"Samsami-Kor","year":"2015","journal-title":"Arch Med Res"},{"key":"R21-20250527","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ctcp.2015.03.001","article-title":"Efficacy of the Punica granatum peels aqueous extract for symptom management in ulcerative colitis patients. A randomized, placebo-controlled, clinical trial.","volume":"21","author":"Kamali","year":"2015","journal-title":"Complement Ther Clin Pract"},{"key":"R22-20250527","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1365-2036.2004.01902.x","article-title":"Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis.","volume":"19","author":"Langmead","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"R23-20250527","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctim.2018.12.021","article-title":"Zingiber officinale and oxidative stress in patients with ulcerative colitis: a randomized, placebo-controlled, clinical trial.","volume":"43","author":"Nikkhah-Bodaghi","year":"2019","journal-title":"Complement Ther Med"},{"key":"R24-20250527","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1007\/s11655-012-1026-x","article-title":"A randomized, double blinded, placebo-controlled clinical trial of silymarin in ulcerative colitis.","volume":"21","author":"Rastegarpanah","year":"2015","journal-title":"Chin J Integr Med"},{"key":"R25-20250527","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1080\/003655202317316088","article-title":"Wheat grass juice in the treatment of active distal ulcerative colitis: a randomized double-blind placebo-controlled trial.","volume":"37","author":"Ben-Arye","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"R26-20250527","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"R27-20250527","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials.","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"R28-20250527","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/ije\/dyn065","article-title":"Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation.","volume":"37","author":"Patsopoulos","year":"2008","journal-title":"Int J Epidemiol"},{"key":"R29-20250527","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range.","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"R30-20250527","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1177\/0962280216669183","article-title":"Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range.","volume":"27","author":"Luo","year":"2018","journal-title":"Stat Methods Med Res"},{"key":"R31-20250527","first-page":"564","article-title":"Ulcerative colitis-diagnostic and therapeutic algorithms.","volume":"117","author":"Kucharzik","year":"2020","journal-title":"Dtsch Arztebl Int"},{"key":"R32-20250527","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0140-6736(07)60751-X","article-title":"Inflammatory bowel disease: clinical aspects and established and evolving therapies.","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet"},{"key":"R33-20250527","doi-asserted-by":"crossref","first-page":"20091","DOI":"10.3390\/molecules191220091","article-title":"The chemistry of curcumin: from extraction to therapeutic agent.","volume":"19","author":"Priyadarsini","year":"2014","journal-title":"Molecules"},{"key":"R34-20250527","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.2147\/DDDT.S327378","article-title":"Anti-inflammatory effects of curcumin in the inflammatory diseases: status, limitations and countermeasures.","volume":"15","author":"Peng","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"R35-20250527","first-page":"102","article-title":"Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4\/NF-\u03baB signaling pathway.","volume":"79","author":"Zeng","year":"2013","journal-title":"Planta Med"},{"key":"R36-20250527","first-page":"34","article-title":"Curcumin ameliorates DSS\u2011induced colitis in mice by regulating the Treg\/Th17 signaling pathway.","volume":"23","author":"Wei","year":"2021","journal-title":"Mol Med Rep"},{"key":"R37-20250527","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.molimm.2018.09.004","article-title":"Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1\u03b2 production.","volume":"104","author":"Gong","year":"2018","journal-title":"Mol Immunol"},{"key":"R38-20250527","doi-asserted-by":"crossref","first-page":"290","DOI":"10.5152\/tjg.2019.18342","article-title":"Curcumin ameliorates dextran sulfate sodium-induced colitis in mice via regulation of autophagy and intestinal immunity.","volume":"30","author":"Yue","year":"2019","journal-title":"Turk J Gastroenterol"},{"key":"R39-20250527","doi-asserted-by":"crossref","first-page":"113256","DOI":"10.1016\/j.biopha.2022.113256","article-title":"Medicinal uses, pharmacological activities, phytochemistry, and the molecular mechanisms of Punica granatum L. (pomegranate) plant extracts: a review.","volume":"153","author":"Maphetu","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"R40-20250527","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3390\/nu9090958","article-title":"Could pomegranate juice help in the control of inflammatory diseases?","volume":"9","author":"Danesi","year":"2017","journal-title":"Nutrients"},{"key":"R41-20250527","doi-asserted-by":"crossref","first-page":"114556","DOI":"10.1016\/j.jep.2021.114556","article-title":"Aloe vera carbohydrates regulate glucose metabolism through improved glycogen synthesis and downregulation of hepatic gluconeogenesis in diabetic rats.","volume":"281","author":"Govindarajan","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"R42-20250527","doi-asserted-by":"crossref","first-page":"114108","DOI":"10.1016\/j.jep.2021.114108","article-title":"Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier.","volume":"279","author":"Shi","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"R43-20250527","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.3390\/molecules27217223","article-title":"Effect of ginger on inflammatory diseases.","volume":"27","author":"Ballester","year":"2022","journal-title":"Molecules"},{"key":"R44-20250527","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1177\/0960327117751235","article-title":"Protective mechanisms of 6-gingerol in dextran sulfate sodium-induced chronic ulcerative colitis in mice.","volume":"37","author":"Ajayi","year":"2018","journal-title":"Hum Exp Toxicol"},{"key":"R45-20250527","doi-asserted-by":"crossref","first-page":"1217165","DOI":"10.3389\/fendo.2023.1217165","article-title":"Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease.","volume":"14","author":"Sahoo","year":"2023","journal-title":"Front Endocrinol"},{"key":"R46-20250527","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.4049\/jimmunol.179.10.7121","article-title":"Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.","volume":"179","author":"Nicholas","year":"2007","journal-title":"J Immunol"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000041985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T04:00:19Z","timestamp":1748318419000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000041985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":46,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000041985","relation":{},"ISSN":["1536-5964"],"issn-type":[{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]}}}