{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:20:50Z","timestamp":1755224450660,"version":"3.43.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"28","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,11]]},"abstract":"<jats:p>Individuals with severe sarcopenia are at a higher risk of adverse health events than those with sarcopenia alone. However, due to the limited number of studies, the condition remains poorly understood. To date, few studies have examined the association between tooth loss and severe sarcopenia. Therefore, we conducted a cross-sectional study to address this gap. Community residents who were 60 years and older, and had attended a local government basic health checkup from March to October in 2022 were recruited. Severe sarcopenia was defined according to the Asian Working Group for Sarcopenia 2019. Loss of occlusal pairs (14 total pairs: 6 anterior occlusal pairs, 8 posterior occlusal pairs [POPs]) was quantified through dental examinations. Logistic regressions were used to evaluate the association between loss of occlusal pairs and severe sarcopenia, adjusting for potential confounding factors. A total of 1421 older adults (42.6% men, 71.4\u2005\u00b1\u20056.8 years old) were enrolled in this study. The prevalence of severe sarcopenia was 8.3%. Multivariate analyses showed that each additional POPs loss increased severe sarcopenia risk (adjusted OR\u2005=\u20051.17, 95% CI\u2005=\u20051.06\u20131.28, <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.001), while anterior occlusal pairs loss showed no association (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u2005.982). From the angle of population group, significant increase in severe sarcopenia was only found in older adults with the highest levels of missing POPs compared to those without (\u0394 high vs low loss: 12.45% (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005&lt;\u2005.001); \u0394 high vs low\u2013medium loss: 10.14% (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005&lt;\u2005.001); \u0394 high vs medium\u2013high loss: 9.85% (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005&lt;\u2005.001)). The identification and management of POPs loss, high loss in particular, could be important in preventing severe sarcopenia in community-dwelling older adults.<\/jats:p>","DOI":"10.1097\/md.0000000000043371","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T18:01:39Z","timestamp":1752516099000},"page":"e43371","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Association between posterior occlusal pairs loss and severe sarcopenia in community-dwelling Chinese older adults: A cross-sectional study"],"prefix":"10.1097","volume":"104","author":[{"given":"Wei","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Shaoxing Stomatological Hospital, Shaoxing, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangkang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Non-communicable Diseases Control and Prevention, Shaoxing Center for Disease Control and Prevention, Shaoxing, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qifeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Non-communicable Diseases Control and Prevention, Shaoxing Center for Disease Control and Prevention, Shaoxing, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8575-0106","authenticated-orcid":false,"given":"Laichao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Non-communicable Diseases Control and Prevention, Shaoxing Center for Disease Control and Prevention, Shaoxing, Zhejiang Province, China"},{"name":"Administrative Office, Shaoxing Center for Disease Control and Prevention, Shaoxing, Zhejiang Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20250812","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment.","volume":"21","author":"Chen","year":"2020","journal-title":"J Am Med Dir Assoc"},{"key":"R2-20250812","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/jcsm.12651","article-title":"Sarcopenia: prevalence, associated factors, and the risk of mortality and disability in Japanese older adults.","volume":"12","author":"Kitamura","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"R3-20250812","first-page":"1781","article-title":"Severe sarcopenia might be associated with a decline of physical independence in older patients undergoing chemotherapeutic treatment.","volume":"26","author":"Rier","year":"2017","journal-title":"Support Care Cancer"},{"key":"R4-20250812","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/jcsm.12783","article-title":"Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis.","volume":"13","author":"Petermann-Rocha","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"R5-20250812","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/ggi.14389","article-title":"Clinical implications of severe sarcopenia in Japanese patients with acute heart failure.","volume":"22","author":"Honda","year":"2022","journal-title":"Geriatr Gerontol Int"},{"key":"R6-20250812","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1093\/eurjpc\/zwaa117","article-title":"Impact of sarcopenia on prognosis in patients with heart failure with reduced and preserved ejection fraction.","volume":"28","author":"Konishi","year":"2021","journal-title":"Eur J Prev Cardiol"},{"key":"R7-20250812","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.maturitas.2020.04.017","article-title":"Physical capability markers used to define sarcopenia and their association with cardiovascular and respiratory outcomes and all-cause mortality: a prospective study from UK Biobank.","volume":"138","author":"Petermann-Rocha","year":"2020","journal-title":"Maturitas"},{"key":"R8-20250812","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/jphd.12433","article-title":"Depression is related to edentulism and lack of functional dentition: an analysis of NHANES data, 2005-2016.","volume":"81","author":"Al-Zahrani","year":"2021","journal-title":"J Public Health Dent"},{"key":"R9-20250812","doi-asserted-by":"crossref","first-page":"e004518","DOI":"10.1161\/JAHA.116.004518","article-title":"History of periodontitis diagnosis and edentulism as predictors of cardiovascular disease, stroke, and mortality in postmenopausal women.","volume":"6","author":"LaMonte","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"R10-20250812","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/annonc\/mdx019","article-title":"Periodontal disease, edentulism, and pancreatic cancer: a meta-analysis.","volume":"28","author":"Maisonneuve","year":"2017","journal-title":"Ann Oncol"},{"key":"R11-20250812","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1741-2358.1999.00011.x","article-title":"The impact of oral health on stated ability to eat certain foods; findings from the national diet and nutrition survey of older people in Great Britain.","volume":"16","author":"Sheiham","year":"1999","journal-title":"Gerodontology"},{"key":"R12-20250812","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis.","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"R13-20250812","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases: a global public health challenge.","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet (London)"},{"key":"R14-20250812","doi-asserted-by":"crossref","first-page":"19551","DOI":"10.1038\/s41598-020-75250-y","article-title":"Prevalence and risk factors of primary sarcopenia in community-dwelling outpatient elderly: a cross-sectional study.","volume":"10","author":"Therakomen","year":"2020","journal-title":"Sci Rep"},{"key":"R15-20250812","doi-asserted-by":"crossref","first-page":"e0247617","DOI":"10.1371\/journal.pone.0247617","article-title":"Sarcopenia prevalence and associated factors among older Chinese population: findings from the China health and retirement longitudinal study.","volume":"16","author":"Wu","year":"2021","journal-title":"PLoS One"},{"key":"R16-20250812","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1159\/000513247","article-title":"The comparison of sarcopenia diagnostic criteria using AWGS 2019 with the other five criteria in West China.","volume":"67","author":"Liu","year":"2021","journal-title":"Gerontology"},{"key":"R17-20250812","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/ggi.12399","article-title":"Relationship between chewing ability and sarcopenia in Japanese community-dwelling older adults.","volume":"15","author":"Murakami","year":"2015","journal-title":"Geriatr Gerontol Int"},{"key":"R18-20250812","doi-asserted-by":"crossref","first-page":"e521","DOI":"10.1016\/S2666-7568(21)00142-2","article-title":"Oral health for healthy ageing.","volume":"2","author":"Patel","year":"2021","journal-title":"Lancet Healthy Longev"},{"key":"R19-20250812","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/s12903-023-03015-w","article-title":"Longitudinal association of edentulism with cognitive impairment, sarcopenia and all-cause mortality among older Chinese adults.","volume":"23","author":"Li","year":"2023","journal-title":"BMC Oral Health"},{"key":"R20-20250812","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s12603-022-1784-x","article-title":"Association of loss of occlusal pairs of teeth with sarcopenia in a Chinese population of community-dwelling elderly.","volume":"26","author":"Lin","year":"2022","journal-title":"J Nutr Health Aging"},{"key":"R21-20250812","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s40520-025-03032-5","article-title":"Association between tooth loss and geriatric syndromes in older adults: a cohort study from a rural area in eastern China.","volume":"37","author":"He","year":"2025","journal-title":"Aging Clin Exp Res"},{"key":"R22-20250812","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1186\/s12877-022-03350-7","article-title":"Nutrition mediates the relationship between number of teeth and sarcopenia: a pathway analysis.","volume":"22","author":"Xia","year":"2022","journal-title":"BMC Geriatr"},{"key":"R23-20250812","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1038\/s41598-022-11714-7","article-title":"Relationship between tooth loss and sarcopenia in suburban community-dwelling older adults in Shanghai and Tianjin of China.","volume":"12","author":"Wang","year":"2022","journal-title":"Sci Rep"},{"key":"R24-20250812","doi-asserted-by":"crossref","first-page":"103511","DOI":"10.1016\/j.jdent.2020.103511","article-title":"The impact of occluding pairs on the chewing patterns among the elderly.","volume":"104","author":"Huang","year":"2021","journal-title":"J Dent"},{"key":"R25-20250812","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.clnu.2017.03.014","article-title":"Relationship of nutritional status and oral health in elderly: systematic review with meta-analysis.","volume":"37","author":"Toniazzo","year":"2018","journal-title":"Clin Nutr"},{"key":"R26-20250812","doi-asserted-by":"crossref","first-page":"101739","DOI":"10.1016\/j.arr.2022.101739","article-title":"Gut microbiota as a promising therapeutic target for age-related sarcopenia.","volume":"81","author":"Zhang","year":"2022","journal-title":"Ageing Res Rev"},{"key":"R27-20250812","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.clnu.2022.05.008","article-title":"Differences in the gut microbiome and reduced fecal butyrate in elders with low skeletal muscle mass.","volume":"41","author":"Han","year":"2022","journal-title":"Clin Nutr"},{"key":"R28-20250812","doi-asserted-by":"crossref","first-page":"100980","DOI":"10.1016\/j.arr.2019.100980","article-title":"Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis.","volume":"56","author":"Livshits","year":"2019","journal-title":"Ageing Res Rev"},{"key":"R29-20250812","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.clnu.2017.06.001","article-title":"Diet-borne systemic inflammation is associated with prevalent tooth loss.","volume":"37","author":"Kotsakis","year":"2018","journal-title":"Clin Nutr"},{"key":"R30-20250812","doi-asserted-by":"crossref","first-page":"glae037","DOI":"10.1093\/gerona\/glae037","article-title":"The potential role and therapeutic relevance of cellular senescence in skeletal pathophysiology.","volume":"79","author":"Li","year":"2024","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"R31-20250812","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/ger.12406","article-title":"Association between oral health and frailty: a systematic review of longitudinal studies.","volume":"36","author":"Hakeem","year":"2019","journal-title":"Gerodontology"},{"key":"R32-20250812","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s40520-016-0630-6","article-title":"Impact of tooth loss on walking speed decline over time in older adults: a population-based cohort study.","volume":"29","author":"Welmer","year":"2017","journal-title":"Aging Clin Exp Res"},{"key":"R33-20250812","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/jgs.15175","article-title":"Influence of poor oral health on physical frailty: a population-based cohort study of older British men.","volume":"66","author":"Ramsay","year":"2018","journal-title":"J Am Geriatr Soc"},{"key":"R34-20250812","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/joor.12949","article-title":"Combined effect of poor appetite and low masticatory function on sarcopenia in community-dwelling Japanese adults aged >\/= 75 years: a 3-year cohort study.","volume":"47","author":"Senoo","year":"2020","journal-title":"J Oral Rehabil"},{"key":"R35-20250812","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1186\/s12903-025-05684-1","article-title":"Prevalence and associated factors of denture use among older adults living in rural and urban areas of China: a national cross-sectional study.","volume":"25","author":"Lin","year":"2025","journal-title":"BMC Oral Health"},{"key":"R36-20250812","doi-asserted-by":"crossref","first-page":"e793","DOI":"10.1111\/j.1741-2358.2011.00563.x","article-title":"Influence of dental treatment on physical performance in community-dwelling elderly persons.","volume":"29","author":"Moriya","year":"2012","journal-title":"Gerodontology"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000043371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T17:00:48Z","timestamp":1755018048000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000043371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":36,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000043371","relation":{},"ISSN":["1536-5964"],"issn-type":[{"type":"electronic","value":"1536-5964"}],"subject":[],"published":{"date-parts":[[2025,7,11]]}}}