{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T06:56:30Z","timestamp":1775458590200,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"35","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Key R&D Program Project of Jiangxi Province","award":["20203BBG73041"],"award-info":[{"award-number":["20203BBG73041"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:p>\n                    This study evaluated the effects of recombinant human growth hormone (rhGH) on bone mineral density (BMD) and body composition in Chinese adolescents with transitional growth hormone deficiency (TGHD). A prospective cohort study was conducted from September 2021 to September 2024, involving 37 TGHD patients (15\u201318 years) and 7 healthy controls. After a 3-month rhGH washout, 9 confirmed TGHD patients (diagnosed per 2019 AACE criteria) were stratified into treatment (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2005=\u20054, rhGH continuation) and non-treatment (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2005=\u20055) groups. Assessments included dual-energy X-ray absorptiometry (DXA) for BMD and body composition, biochemical profiling, grip strength, and cardiac ultrasound. Statistical analyses utilized SPSS 27.0. At baseline, TGHD patients exhibited elevated lean body mass (63.33\u2005\u00b1\u200515.58% vs 37.47\u2005\u00b1\u20052.27%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.001) and fat mass (FM) (33.28\u2005\u00b1\u20057.33% vs 24.93\u2005\u00b1\u20050.86%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.002) compared to controls. After 6 months, rhGH-treated patients demonstrated significant improvements in lumbar BMD (0.74\u2005\u00b1\u20050.58 vs 0.53\u2005\u00b1\u20050.12\u2009g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005&lt;\u2005.05) and grip strength (left: 33.20\u2005\u00b1\u20052.82 vs 21.47\u2005\u00b1\u20051.25\u2009kg; right: 32.66\u2005\u00b1\u20054.70 vs 21.66\u2005\u00b1\u20051.49\u2009kg,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005&lt;\u2005.05), whereas untreated patients showed BMD decline (0.42\u2005\u00b1\u20050.55 vs 0.59\u2005\u00b1\u20050.85\u2009g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005&lt;\u2005.05) and grip deterioration (16.24\u2005\u00b1\u20052.43 vs 23.84\u2005\u00b1\u20052.86\u2009kg,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005&lt;\u2005.05). Untreated TGHD patients developed dyslipidemia, with elevated triglycerides (4.42\u2005\u00b1\u20050.66 vs 0.94\u2005\u00b1\u20050.53 mmol\/L,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005&lt;\u2005.05) and LDL-C (5.75\u2005\u00b1\u20050.97 vs 2.63\u2005\u00b1\u20050.31 mmol\/L,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005&lt;\u2005.05) versus controls. No significant changes in growth velocity, IGF-1, or cardiac function were observed (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005&gt;\u2005.05). Continued rhGH therapy during the transitional phase improves BMD, preserves favorable body composition, and mitigates metabolic risks in TGHD patients. Discontinuation exacerbates musculoskeletal deficits and lipid abnormalities, underscoring the necessity of sustained GH replacement until peak bone mass attainment. These findings highlight the critical role of rhGH beyond linear growth optimization in TGHD management.\n                  <\/jats:p>","DOI":"10.1097\/md.0000000000044178","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T19:02:09Z","timestamp":1756494129000},"page":"e44178","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of growth hormone on bone density and body composition in Chinese patients with transitional growth hormone deficiency"],"prefix":"10.1097","volume":"104","author":[{"given":"Qingbo","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Jiangxi Provincial Children\u2019s Hospital, Jiangxi, China"},{"name":"The Affiliated Children\u2019s Hospital of Nanchang Medical College, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jiangxi Provincial Children\u2019s Hospital, Jiangxi, China"},{"name":"The Affiliated Children\u2019s Hospital of Nanchang Medical College, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangwei","family":"Ke","sequence":"additional","affiliation":[{"name":"The Affiliated Children\u2019s Hospital of Nanchang Medical College, Jiangxi, China"},{"name":"Department of Laboratory Medicine, Jiangxi Provincial Children\u2019s Hospital, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liling","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jiangxi Provincial Children\u2019s Hospital, Jiangxi, China"},{"name":"The Affiliated Children\u2019s Hospital of Nanchang Medical College, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jiangxi Provincial Children\u2019s Hospital, Jiangxi, China"},{"name":"The Affiliated Children\u2019s Hospital of Nanchang Medical College, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuqiang","family":"Wu","sequence":"additional","affiliation":[{"name":"The Affiliated Children\u2019s Hospital of Nanchang Medical College, Jiangxi, China"},{"name":"Jiangxi Children\u2019s Hospital Imaging Center, Jiangxi Provincial Children\u2019s Hospital, Jiangxi, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jiangxi Provincial Children\u2019s Hospital, Jiangxi, China"},{"name":"The Affiliated Children\u2019s Hospital of Nanchang Medical College, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5209-4766","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jiangxi Provincial Children\u2019s Hospital, Jiangxi, China"},{"name":"The Affiliated Children\u2019s Hospital of Nanchang Medical College, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20260406","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s40618-014-0201-7","article-title":"Growth hormone treatment of adolescents with growth hormone deficiency (GHD) during the transition period: results of a survey among adult and paediatric endocrinologists from Italy. 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