{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:48:23Z","timestamp":1779889703469,"version":"3.53.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"36","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Previous studies have reported inconsistent findings regarding the diagnostic role of Krebs Von den Lungen-6 (KL-6) in dermatomyositis\/polymyositis-associated interstitial lung disease (PM\/DM-ILD) and its correlation with disease severity. This meta-analysis aimed to evaluate the diagnostic efficacy of serum KL-6 in detecting DM\/PM-ILD and its association with pulmonary function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In April 2023, we systematically searched PubMed, Web of Science, Cochrane Library, CNKI, Wan Fang, and VIP databases to identify studies investigating the association of KL-6 with DM\/PM-ILD. Two authors independently screened the literature and assessed the risk of bias for included studies. Data synthesis and analysis were performed using SPSS 20.0 (Chicago), Excel, and Stata 15.0 software, with effect sizes calculated using standard mean differences and 95% confidence intervals (CIs). Diagnostic accuracy was assessed using sensitivity, specificity, and summary receiver operating characteristic curve analysis. This meta-analysis was registered in INPLASY. https:\/\/inplasy.com\/inplasy-2022-6-0106\/.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 334 studies retrieved, 9 were included in this meta-analysis. The analysis showed that serum KL-6 levels were significantly higher in DM\/PM patients with ILD compared to those without ILD (WMD\u2005=\u2005757.15, 95% CI: 558.88\u2013885.41,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005&lt;.05). Serum KL-6 demonstrated a sensitivity of 0.82 (95% CI: 0.73\u20130.89), specificity of 0.90 (95% CI: 0.77\u20130.96), and an area under the combined summary receiver operating characteristic curve of 0.91 (95% CI: 0.89\u20130.94). Correlation analyses revealed significant associations between KL-6 levels and various pulmonary function parameters (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005&lt;.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serum KL-6 shows promise as a diagnostic marker for DM\/PM-ILD and is closely associated with disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/md.0000000000044396","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T18:09:45Z","timestamp":1757354985000},"page":"e44396","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic efficacy of serum Krebs von den Lungen-6 for dermatomyositis\/polymyositis-associated interstitial lung diseases: A systematic review and meta-analysis"],"prefix":"10.1097","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5906-571X","authenticated-orcid":false,"given":"Zifeng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, The First College of Clinical Medical Science, Three Gorges University\/Yichang Central People\u2019s Hospital, Yichang City, Hubei Province, China"},{"name":"Academic Research Center, Yichang Famous Doctor Studio, Yichang City, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8868-9193","authenticated-orcid":false,"given":"Luhuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia"},{"name":"Academic Research Center, Yichang Hubo Medical Research Institute, Yichang City, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-2554","authenticated-orcid":false,"given":"Zuyang","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Nursing, the First College of Clinical Medical Science, Three Gorges University\/Yichang Central People\u2019s Hospital, Yichang City, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, The First College of Clinical Medical Science, Three Gorges University\/Yichang Central People\u2019s Hospital, Yichang City, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhi","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The First College of Clinical Medical Science, Three Gorges University\/Yichang Central People\u2019s Hospital, Yichang City, Hubei Province, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, The First College of Clinical Medical Science, Three Gorges University\/Yichang Central People\u2019s Hospital, Yichang City, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4838-2709","authenticated-orcid":false,"given":"Yunhong","family":"Lei","sequence":"additional","affiliation":[{"name":"Academic Research Center, Yichang Hubo Medical Research Institute, Yichang City, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251029","doi-asserted-by":"crossref","first-page":"e1190","DOI":"10.1002\/iid3.1190","article-title":"A bibliometric analysis of the research status and trends in studies on polymyositis and dermatomyositis with 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