{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:59:28Z","timestamp":1790189968248,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"37","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,12]]},"abstract":"<jats:p>\n                    Studies have implicated the gut microbiota as significant in bone condition, influencing osteoporosis through immune modulation, endocrine regulation, and metabolite production. Our study explores the plasma metabolites\u2019 mediation effect between gut microbiomes and osteoporosis through Mendelian randomization (MR). Using publicly accessible GWAS data from 5959 individuals for gut microbiota and 8299 individuals for plasma metabolites, we employed MR analysis to explore their causal effects on osteoporosis. Osteoporosis outcome data were obtained from Pan-UKB, GERA, and FinnGen, covering 21,353 cases and 853,313 controls. Mediation effects of identified bacterial taxa on osteoporosis through plasma metabolites were computed using the product-of-coefficients approach. Our MR analysis identified several gut microbiomes and plasma metabolites potentially associated with osteoporosis. Notably, increased abundances of certain gut microbiomes like\n                    <jats:italic toggle=\"yes\">Desulfobacterota<\/jats:italic>\n                    were linked with higher osteoporosis risk. Mediation analysis revealed that specific plasma metabolites like 5alpha-androstan-3alpha,17beta-diol monosulfate (3\u03b1-diol MS) levels significantly mediated the effects of these microbiomes on osteoporosis, explaining up to 9.15% of their effect. This study confirms the profound impact of gut microbiota on osteoporosis risk, mediated through specific plasma metabolites. These findings enhance our comprehension of the microbiota\u2013bone health axis and could lead to new biomarkers or therapeutic targets for osteoporosis management, emphasizing the potential for modifying gut microbiota to mitigate disease risk.\n                  <\/jats:p>","DOI":"10.1097\/md.0000000000044409","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T21:02:04Z","timestamp":1757970124000},"page":"e44409","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["The role of gut microbiota and plasma metabolites in osteoporosis: Insights from Mendelian randomization analysis"],"prefix":"10.1097","volume":"104","author":[{"given":"WeiDong","family":"Zhu","sequence":"first","affiliation":[{"name":"Emergency Department, Wujin People\u2019s Hospital Affiliated with Jiangsu University and Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShuWei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, the Ninth Medical Center, Chinese PLA General Hospital, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XuWen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Emergency Department, Wujin People\u2019s Hospital Affiliated with Jiangsu University and Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinNan","family":"Yin","sequence":"additional","affiliation":[{"name":"Emergency Department, Wujin People\u2019s Hospital Affiliated with Jiangsu University and Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260923","first-page":"105","article-title":"The 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