{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:18:50Z","timestamp":1789496330693,"version":"build-2803163510"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Short telomere length (TL) has been associated with chronic diseases and reduced lifespan. Vitamin D may help preserve telomeres through its anti-inflammatory effects; however, the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and TL remains inconclusive. This meta-analysis was conducted to evaluate the association between circulating 25(OH)D and leukocyte TL (LTL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A comprehensive literature search was performed across PubMed, Scopus, Google Scholar, ClinicalTrials.gov, and Cochrane Library to identify relevant studies published up to February 2025. Standardized \u03b2 coefficients with 95% confidence intervals were applied as the effect size metric to evaluate the associations using a random effect model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 21 studies comprising 185,191 participants were analyzed. The overall results demonstrated a positive association between serum 25(OH)D levels and LTL (\u03b2\u2005=\u20050.04, 95% CI\u2005=\u20050.02\u20130.06), with remarkable heterogeneity across studies (I\u00b2= 89.1%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005\u2264.001). This association was supported in adults (\u03b2\u2005=\u20050.04, 95% CI\u2005=\u20050.03\u20130.06), women (\u03b2\u2005=\u20050.05, 95% CI\u2005=\u20050.01\u20130.08), individuals with vitamin D deficiency (\u03b2\u2005=\u20050.22, 95% CI\u2005=\u20050.01\u20130.43), and studies that adjusted for covariates (\u03b2\u2005=\u20050.05, 95% CI\u2005=\u20050.01\u20130.08). No significant associations were found in men, participants with serum 25(OH)D levels\u2005\u2265\u200530\u2009ng\/mL, children, or studies without covariate adjustments. The relationships were not influenced by the method of TL assessment, body mass index, smoking status, and sample size.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serum 25(OH)D levels showed a positive correlation with LTL in women, adults, and individuals with vitamin D deficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/md.0000000000044487","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T19:00:13Z","timestamp":1770404413000},"page":"e44487","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The association of serum levels of vitamin D with leucocyte telomere length, as a marker of biological aging: A meta-analysis"],"prefix":"10.1097","volume":"105","author":[{"given":"Jie","family":"Shen","sequence":"first","affiliation":[{"name":"Hebi Vocational and Technical College, Hebi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Hebi Vocational and Technical College, Hebi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Hebi Vocational and Technical College, Hebi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Fan","sequence":"additional","affiliation":[{"name":"General Surgery Ward 2, Hebi People\u2019s Hospital, Hebi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4983-4043","authenticated-orcid":false,"given":"Guanghui","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Affairs 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