{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:29:06Z","timestamp":1787160546218,"version":"build-2736575974"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"39","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,26]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aimed to assess the radiological and clinical outcomes of mineral trioxide aggregates (MTA) versus grape seed extract (GSE) when used as a dressing material in primary teeth undergoing pulpotomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a prospective split-mouth randomized clinical study. A total of 32 primary teeth were included and split into 2 groups: MTA was used in group I, and GSE was used in group II. A clinical and radiographic follow-up was conducted for 6 months postoperatively. Periapical radiographs were taken for all treated teeth at 3- and 6-month follow-up visits. Radiographic criteria for clinical success included absence of internal resorption, pathologic external resorption, interradicular radiolucency, periapical radiolucency, and widening of the periodontal ligament space.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>\n                      In the MTA group, clinical and radiographic success was 100% at 1 and 3 months, in comparison to 93.75% 6 months postoperatively. In the GSE group, clinical success was 100% 1 month, and 93.75% 3 and 6 months postoperatively, while radiographic success was 100% at 3 months, 87.5% 6 months postoperatively. There were no significant statistical differences in the overall clinical or radiographic outcomes between the study groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Both MTA and GSE are associated with successful clinical and radiographic outcomes of pulpotomy; however, MTA seems to be associated with reduced inflammatory reactions, rendering it more effective than GSE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/md.0000000000044827","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:03:07Z","timestamp":1759248187000},"page":"e44827","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and radiological assessment of grape seed extract versus mineral trioxide aggregates in primary molar pulpotomy: A randomized controlled clinical trial"],"prefix":"10.1097","volume":"104","author":[{"given":"Noura Mohammed","family":"Bakr","sequence":"first","affiliation":[{"name":"Department of Oral and Dental Biology, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gihan Adel","family":"Balbola","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1644-6172","authenticated-orcid":false,"given":"Soha Fuad","family":"Alqadi","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences, College of Dentistry, Taibah University, Madinah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najla","family":"Dar-Odeh","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, College of Dentistry, Taibah University, Madinah, Saudi Arabia"},{"name":"Department of Oral and Maxillofacial Surgery, Oral Medicine and Periodontology, School of Dentistry, The University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadia","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, College of Dentistry, Taibah University, Madinah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuha","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Sciences, College of Dentistry, King Khalid University, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisreen Nabiel","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences, College of Dentistry, Taibah University, Madinah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara N.","family":"Hashem","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Oral Health, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safaa Ramadan","family":"El Sayed","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Oral Health, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260602","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2485\/jhtb.25.321","article-title":"Experimental study of pulp capping using xenogenic demineralized dentin 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