{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T04:20:59Z","timestamp":1768364459309,"version":"3.49.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"41","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,10]]},"abstract":"<jats:p>\n                    This study investigated the relationship between increased brain natriuretic peptide (BNP) levels following aneurysm rupture and the incidence of major adverse cardiac events (MACE), perioperative complications, and long-term neurological outcomes. We included patients with aneurysmal subarachnoid hemorrhage within 72 hours of bleeding, collecting comprehensive clinical data. Participants were divided into 2 groups based on initial serum BNP levels: elevated (&gt;100 pg\/mL) and non-elevated (\u2264100 pg\/mL). To mitigate bias, propensity score matching was employed to balance statistically significant variables. Follow-up assessments focused on in-hospital complications, MACE, and neurological outcomes. A total of 213 patients were analyzed, with an average age of 57.4\u2005\u00b1\u200512.1 years; 61.5% were women. The average follow-up duration was 34.3 months, with hypertension and coronary heart disease as common histories. After propensity score matching, the elevated BNP group showed higher rates of myocardial infarction (13.3% vs 4.0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.001), acute heart failure (25.3% vs 4.0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.042), delayed cerebral ischemia (25.3% vs 10.7%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.032), and hydrocephalus (13.3% vs 1.3%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.009). However, there was no significant difference in MACE between groups during follow-up. Logistic regression identified admission BNP as an independent risk factor for MACE (OR: 4.029, 95% CI: 1.753\u20139.262,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.001), myocardial infarction (OR: 4.405,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.038), heart failure (OR: 8.420,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.002), delayed cerebral ischemia (OR: 3.449,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.013), and hydrocephalus (OR: 13.726,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.020). Elevated BNP levels after intracranial aneurysm rupture are associated with MACE, delayed cerebral ischemia, and hydrocephalus during hospitalization, but not with neurological status or MACE at discharge and follow-up.\n                  <\/jats:p>","DOI":"10.1097\/md.0000000000044985","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T05:02:34Z","timestamp":1760331754000},"page":"e44985","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical application research of brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage"],"prefix":"10.1097","volume":"104","author":[{"given":"Aiying","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuijie","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8014-6091","authenticated-orcid":false,"given":"Wei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, 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