{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:02:08Z","timestamp":1789502528955,"version":"build-2803163510"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"42","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,17]]},"abstract":"<jats:p>\n                    The purpose of this study was to evaluate the functional and corneal structural outcomes in the young population of keratoconus before and after accelerated transepithelial corneal collagen cross-linking (ATE-CXL) at 9 mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    for 10 minutes. In this prospective cohort study, ATE-CXL was performed on 36 eyes. The best-corrected visual acuity, spheris, astigmatism, K1, K2, Kmean, central corneal thickness, and intraocular pressure (IOP) were all evaluated. The follow-up time ranged from 2 weeks to 6 months after the procedure. The best-corrected visual acuity results improved significantly from 2 weeks (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005&lt;.001), 1.5 months (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005&lt;.001), and at 6 months postoperation (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005&lt;.001). ATE-CXL significantly reduced the patients\u2019 astigmatism after 6 months (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2005=\u2005.03). Following the procedure, there was a modest reduction in the K1, K2, and Kmean in the keratoconus patients. The intraocular pressure and central corneal thickness did not differ significantly at different time points. No postoperative complications were discovered following the procedure. ATE CXL demonstrated an early improvement in the patients\u2019 visual acuity and astigmatism in the Indonesian young population, and it was regarded as a safe and efficient keratoconus treatment. Further research with larger sample sizes and longer follow-up periods are required to confirm these findings.\n                  <\/jats:p>","DOI":"10.1097\/md.0000000000045003","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:02:31Z","timestamp":1762210951000},"page":"e45003","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Reducing astigmatism following accelerated transepithelial corneal collagen cross-linking for keratoconus: A prospective study"],"prefix":"10.1097","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6152-0881","authenticated-orcid":false,"given":"Reny","family":"Setyowati","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-5537","authenticated-orcid":false,"given":"Rifa","family":"Widyaningrum","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6911-9382","authenticated-orcid":false,"given":"Supanji","family":"Supanji","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4447-6177","authenticated-orcid":false,"given":"Khadijah","family":"Zai","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1496-2855","authenticated-orcid":false,"given":"Agus","family":"Supartoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260915","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00417-018-3966-0","article-title":"Current perspectives on corneal collagen crosslinking (CXL).","volume":"256","author":"Subasinghe","year":"2018","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R2-20260915","doi-asserted-by":"crossref","first-page":"686630","DOI":"10.3389\/fphar.2021.686630","article-title":"Corneal cross-linking: the evolution of treatment 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