{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:06:05Z","timestamp":1785769565586,"version":"3.56.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"51","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bengbu Medical University's Natural Science Foundation","award":["2023byzd248,2024byzd382,2024byzd391,2024byzd402)"],"award-info":[{"award-number":["2023byzd248,2024byzd382,2024byzd391,2024byzd402)"]}]},{"name":"Scientific Research Program of Higher Education Institutions in Anhui Province(","award":["2024AH050703"],"award-info":[{"award-number":["2024AH050703"]}]},{"name":"Hefei Second People's Hospital hospital-level topics","award":["2024ykc001, 2024ykc002\u00ef\u00bc\u01522024ykc010"],"award-info":[{"award-number":["2024ykc001, 2024ykc002\u00ef\u00bc\u01522024ykc010"]}]},{"name":"nhui Provincial Health Research Program","award":["2024Ab0233"],"award-info":[{"award-number":["2024Ab0233"]}]},{"name":"Baekchun Public Welfare Foundation","award":["BFC-QYWL-QL-20240906-02"],"award-info":[{"award-number":["BFC-QYWL-QL-20240906-02"]}]},{"name":"Doctoral Degree Special Grant Fund","award":["2022bszx02"],"award-info":[{"award-number":["2022bszx02"]}]},{"name":"Medical Research Project of Hefei Municipal Health and Wellness Commission","award":["Hwk2023zd012,Hwk2024zd016"],"award-info":[{"award-number":["Hwk2023zd012,Hwk2024zd016"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,19]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>This section discusses the etiology, pathogenesis, clinical manifestations, diagnosis, treatment, and prognosis of primary nodular pulmonary amyloidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient concerns:<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of a 60-year-old female patient at Shanghai Chest Hospital who was diagnosed with primary polymorphic pulmonary amyloidosis following the detection of pulmonary nodules during a chest computed tomography (CT) scan as part of a routine physical examination. The analysis encompassed clinical symptoms, imaging and laboratory findings, bronchoscopy results, and medication history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis:<\/jats:title>\n                    <jats:p>Primary nodular pulmonary amyloidosis<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>The patient presented no clinical symptoms. A chest CT scan performed during physical examination revealed pulmonary nodules. These nodules were located extra-luminal. Pathological tissue was obtained via transbronchial needle aspiration under bronchoscopic guidance, utilizing a combination of cone beam computed tomography and rpEBUS. Pathological findings demonstrated polymorphic plasma cell infiltration and multinucleated giant cell proliferation within the pulmonary interstitium, accompanied by deposition of eosinophilic amorphous material. Congo red staining yielded a positive result.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes:<\/jats:title>\n                    <jats:p>Primary nodular pulmonary amyloidosis lacks specific clinical and imaging manifestations and requires pathological examination and Congo red staining to confirm the diagnosis. There is no recognized treatment option, but early diagnosis and treatment have a certain role in prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lessons:<\/jats:title>\n                    <jats:p>Primary nodular pulmonary amyloidosis may present asymptomatically and requires confirmation through a rigorous diagnostic process. Although treatment options are limited, early detection remains crucial for optimizing patient prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/md.0000000000046292","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T04:01:43Z","timestamp":1766203303000},"page":"e46292","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Primary nodular pulmonary amyloidosis: A case report"],"prefix":"10.1097","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4029-538X","authenticated-orcid":false,"given":"Chuchu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second People\u2019s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second People\u2019s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second People\u2019s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second People\u2019s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second People\u2019s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China"},{"name":"Department of Respiratory and Critical Care Medicine, Hefei Second People\u2019s Hospital, Bengbu Medical University, Hefei, Anhui, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second People\u2019s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangbin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second People\u2019s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7216-5406","authenticated-orcid":false,"given":"Yongsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second People\u2019s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260522","first-page":"101427","article-title":"Pulmonary amyloidosis mimicking interstitial lung disease and malignancy - A case series with a review of a pulmonary patterns.","volume":"33","author":"Zimna","year":"2021","journal-title":"Respir Med Case Rep"},{"key":"R2-20260522","doi-asserted-by":"crossref","first-page":"170046","DOI":"10.1183\/16000617.0046-2017","article-title":"The lung in amyloidosis.","volume":"26","author":"Milani","year":"2017","journal-title":"Eur Respir Rev"},{"key":"R3-20260522","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1378\/chest.15-1539","article-title":"Amyloid-associated cystic lung disease.","volume":"149","author":"Zamora","year":"2016","journal-title":"Chest"},{"key":"R4-20260522","doi-asserted-by":"crossref","first-page":"bcr2017220428","DOI":"10.1136\/bcr-2017-220428","article-title":"Nodular pulmonary amyloidosis: a complex disease with malignancy association.","volume":"2017","author":"Core","year":"2017","journal-title":"BMJ Case Rep"},{"key":"R5-20260522","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1440-1843.2010.01772.x","article-title":"Pulmonary amyloidosis in Sjogren\u2019s syndrome: a case report and systematic review of the literature.","volume":"15","author":"Rajagopala","year":"2010","journal-title":"Respirology"},{"key":"R6-20260522","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2169\/internalmedicine.8169-21","article-title":"Nodular pulmonary amyloidosis associated with Sj\u00f6gren\u2019s syndrome.","volume":"61","author":"Kinoshita","year":"2022","journal-title":"Intern Med"},{"key":"R7-20260522","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.humpath.2009.11.019","article-title":"Nodular senile pulmonary amyloidosis: a unique case con rmed by immunohistochemistry, mass spectrometry, and genetic study.","volume":"41","author":"Roden","year":"2010","journal-title":"Hum Pathol"},{"key":"R8-20260522","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1007\/s10067-007-0552-y","article-title":"Nodular pulmonary amyloidosis in a patient with rheumatoid arthritis.","volume":"26","author":"Calatayud","year":"2007","journal-title":"Clin Rheumatol"},{"issue":"Suppl 1","key":"R9-20260522","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/13506129.2011.574354045","article-title":"Kappa L-chain primary nodular lung amyloidosis: a case report.","volume":"18","author":"Moscatelli","year":"2011","journal-title":"Amyloid"},{"key":"R10-20260522","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s11748-010-0748-y","article-title":"Localized nodular amyloidosis of the lung.","volume":"59","author":"Eguchi","year":"2011","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"R11-20260522","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2169\/internalmedicine.45.1487","article-title":"Three cases of the nodular pulmonary amyloidosis with a longterm observation.","volume":"45","author":"Suzuki","year":"2006","journal-title":"Intern Med"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MD.0000000000046292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:15:54Z","timestamp":1785766554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1097\/MD.0000000000046292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":11,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000046292","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"2025-05-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}