{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:04:41Z","timestamp":1765814681078,"version":"3.48.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"50","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Sichuan Provincial Geriatrics Clinical Research Center Open Project","award":["No.24LNYXSSA01"],"award-info":[{"award-number":["No.24LNYXSSA01"]}]},{"name":"Sichuan Provincial Medical Research Project","award":["No.S23057&2021HR16"],"award-info":[{"award-number":["No.S23057&2021HR16"]}]},{"name":"Chengdu Medical Research Project","award":["No.2023260"],"award-info":[{"award-number":["No.2023260"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,12]]},"abstract":"<jats:p>\n                    The ongoing discourse examines the connection between chronic kidney disease (CKD) and the estimated status of plasma volume (ePVS). In this context, we aimed to assess how effectively ePVS can influence both the prevalence of CKD and the risk of mortality, including from cardiovascular disease (CVD), in CKD patients. This study utilized data from 25,142 eligible participants in the NHANES 1999 to 2018 cohort. We employed binary logistic regression, Cox proportional hazards models, restricted cubic splines (RCS), and threshold analyses to investigate the association between ePVS and CKD. Additionally, we examined the relationship between ePVS and mortality outcomes, including all-cause and cardiovascular mortality. Of the 25,142 study participants, the weighted prevalence of CKD was 18.04%. A nonlinear correlation was observed between ePVS and CKD prevalence. Furthermore, a positive correlation was identified between ePVS and CKD risk, with ePVS values exceeding the threshold of 3.198 associated with an increased risk of CKD development. Therefore, ROC curves indicated that ePVS demonstrated modest discrimination in forecasting CKD. Overall, the relationship between ePVS and both CKD occurrence and all-cause, CVD mortality among patients with CKD was found to be stable across the majority of analyzed subgroups (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    for interactions\u2005&gt;\u2005.05). ePVS levels increased with the prevalence of CKD. Furthermore, early detection and intervention for elevated ePVS levels in CKD patients may influence the progression of CKD and improve their prognosis.\n                  <\/jats:p>","DOI":"10.1097\/md.0000000000046366","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:01:10Z","timestamp":1765814470000},"page":"e46366","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Association between the estimated plasma volume status and chronic kidney disease: A cross-sectional study"],"prefix":"10.1097","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8238-7488","authenticated-orcid":false,"given":"Xuyang","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Nephrology, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"},{"name":"Department of Nephrology, Sichuan Provincial People\u2019s Hospital Xinjin Hospital, Chengdu Xinjin District People\u2019s Hospital, Chengdu, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-4152","authenticated-orcid":false,"given":"Fei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"},{"name":"Department of Nephrology, Sichuan Provincial People\u2019s Hospital Xinjin Hospital, Chengdu Xinjin District People\u2019s Hospital, Chengdu, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20251215","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022.","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int Suppl"},{"key":"R2-20251215","doi-asserted-by":"crossref","first-page":"e002922","DOI":"10.1161\/CIRCHEARTFAILURE.115.002922","article-title":"Fluid volume overload and congestion in heart failure: time to reconsider pathophysiology and how volume is assessed.","volume":"9","author":"Miller","year":"2016","journal-title":"Circ Heart Failure"},{"key":"R3-20251215","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijcard.2018.01.067","article-title":"Prevalence, predictors and clinical outcome of residual congestion in acute decompensated heart failure.","volume":"258","author":"Rubio-Gracia","year":"2018","journal-title":"Int J Cardiol"},{"key":"R4-20251215","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association task force on practice guidelines.","volume":"62","author":"Yancy","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"R5-20251215","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cardfail.2016.08.008","article-title":"Plasma volume is normal but heterogeneously distributed, and true anemia is highly prevalent in patients with stable heart failure.","volume":"23","author":"Nijst","year":"2017","journal-title":"J Card Fail"},{"key":"R6-20251215","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jchf.2014.02.007","article-title":"Understanding the heterogeneity in volume overload and fluid distribution in decompensated heart failure is key to optimal volume management: role for blood volume quantitation.","volume":"2","author":"Miller","year":"2014","journal-title":"JACC Heart Failure"},{"key":"R7-20251215","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1001\/jamainternmed.2022.6817","article-title":"Prevalence of chronic kidney disease in China: results from the sixth china chronic disease and risk factor surveillance.","volume":"183","author":"Wang","year":"2023","journal-title":"JAMA Int Med"},{"key":"R8-20251215","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1681\/ASN.2020121780","article-title":"National estimates of CKD prevalence and potential impact of estimating glomerular filtration rate without race.","volume":"32","author":"Duggal","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"R9-20251215","first-page":"e484","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines.","volume":"138","author":"Whelton","year":"2018","journal-title":"Circulation"},{"issue":"Suppl 1","key":"R10-20251215","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.2337\/dc23-S002","article-title":"2. Classification and diagnosis of diabetes: standards of care in diabetes-2023.","volume":"46","author":"Elsayed","year":"2023","journal-title":"Diabetes Care"},{"key":"R11-20251215","doi-asserted-by":"crossref","first-page":"e0237601","DOI":"10.1371\/journal.pone.0237601","article-title":"Impact of calculated plasma volume status on all-cause and cardiovascular mortality: 4-year nationwide community-based prospective cohort study.","volume":"15","author":"Otaki","year":"2020","journal-title":"PLoS One"},{"key":"R12-20251215","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines.","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"R13-20251215","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cardfail.2018.07.462","article-title":"Calculated estimates of plasma volume in patients with chronic heart failure-comparison with measured volumes.","volume":"24","author":"Fudim","year":"2018","journal-title":"J Card Fail"},{"key":"R14-20251215","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1007\/s11357-023-01044-5","article-title":"Baseline and usual triglyceride-glucose index and the risk of chronic kidney disease: a prospective cohort study.","volume":"46","author":"Kunutsor","year":"2024","journal-title":"GeroScience"},{"key":"R15-20251215","doi-asserted-by":"crossref","first-page":"e230","DOI":"10.1210\/clinem\/dgac735","article-title":"Sex-specific trajectories of insulin resistance markers and reduced renal function during 18 years of follow-up: TLGS.","volume":"108","author":"Amouzegar","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"R16-20251215","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ejhf.193","article-title":"Calculated plasma volume status and prognosis in chronic heart failure.","volume":"17","author":"Ling","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"R17-20251215","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/ejhf.1407","article-title":"Prognostic implications of plasma volume status estimates in heart failure with preserved ejection fraction: insights from TOPCAT.","volume":"21","author":"Grodin","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"R18-20251215","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/heartjnl-2018-314246","article-title":"Calculated plasma volume status and outcomes in patients undergoing coronary bypass graft surgery.","volume":"105","author":"Maznyczka","year":"2019","journal-title":"Heart"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000046366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:01:12Z","timestamp":1765814472000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000046366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":18,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000046366","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,12]]},"assertion":[{"value":"2025-08-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}