{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:59:58Z","timestamp":1776841198011,"version":"3.51.2"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinical Research and Application of Ultrasound-Guided Stellate Ganglion Block for Neurogenic Tinnitus Treatment","award":["2021SF-265"],"award-info":[{"award-number":["2021SF-265"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3,20]]},"abstract":"<jats:sec>\n                    <jats:title>\u00a0<\/jats:title>\n                    <jats:p>\n                      This study aimed to evaluate the effectiveness and safety of combined medication therapy and ultrasound-guided stellate ganglion block treatment for primary tinnitus. This retrospective cohort study reviewed the clinical data of 113 patients with primary tinnitus, with 46 patients receiving stellate ganglion block treatment as the control group and 67 patients receiving the combined medication therapy combined with ultrasound-guided stellate ganglion block treatment as the observation group. Baseline characteristics, tinnitus severity scores, quality of life, psychological health, adverse events, and patient satisfaction were assessed and compared between the 2 treatment groups. Baseline demographics and tinnitus characteristics were similar between groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005&gt;\u2005.05). Posttreatment, the observation group showed significantly greater improvements in tinnitus severity (all metrics,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005&lt;\u2005.05), quality of life (physical, emotional, role, cognitive, social domains,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005&lt;\u2005.005), and psychological health (anxiety, depression, stress, sleep, social support,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005&lt;\u2005.05). Adverse events (headache, dizziness, nausea) were comparable (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005&gt;\u2005.05). Patient satisfaction favored the observation group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u2005.034), though fewer reported \u201cvery satisfied\u201d. The combined intervention demonstrates superior efficacy across clinical and psychosocial outcomes with comparable safety. Medication therapy combined with ultrasound-guided stellate ganglion block treatment significantly reduces tinnitus severity. However, due to the retrospective observational nature of this study, the findings demonstrate an association rather than a causal relationship.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/md.0000000000048044","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T20:01:38Z","timestamp":1774036898000},"page":"e48044","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Combined drug therapy with ultrasound-guided stellate ganglion block for primary tinnitus"],"prefix":"10.1097","volume":"105","author":[{"given":"Zhifu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Bao Ji People\u2019s Hospital, Baoji City, Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Medicine, Baoji Third People\u2019s Hospital, Baoji City, Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Bao Ji People\u2019s Hospital, Baoji City, Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peirong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endemic Disease Control, Baoji City Center for Disease Control and Prevention, Baoji City, Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guochang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Bao Ji People\u2019s Hospital, Baoji City, Shaanxi Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Bao Ji People\u2019s Hospital, Baoji City, Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7514-053X","authenticated-orcid":false,"given":"Ruiling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Bao Ji People\u2019s Hospital, Baoji City, Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1152\/physrev.00029.2020","article-title":"What\u2019s the buzz? 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